Environmental Health News

Peppers Prevent Parkinson's?

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Green, yellow, and red peppers

All varieties of peppers are in the same botanical family as tobacco and contain nicotine. A new study shows that eating peppers may reduce the risk of Parkinson’s disease.


Luc Viatour/www.Lucnix.be.

New Study Suggests Dietary Nicotine May Be Protective

A new study from the Schools of Public Health and Medicine have found that peppers—in the same botanical family as tobacco—may reduce the risk of Parkinson’s disease. Findings are reported in the May 9 edition of the Annals of Neurology, a journal of the American Neurological Association and Child Neurology Society.

Nearly one million people in the United States are living with Parkinson’s disease, a neurodegenerative disorder that results from the loss of dopamine-producing brain cells. In early stages, the disorder is characterized by difficulties in controlling movement, such as hand tremors, limb rigidity, and difficulty walking. As the disease progresses, cognitive problems may develop, advancing into dementia.

Susan Searles Nielsen

Susan Searles Nielsen. Photo: Sarah Fish.

Dietary sources of nicotine may prove protective. “Eating peppers twice or more per week was consistently associated with at least 30 percent reduced risk of developing Parkinson’s disease,” said the study’s lead author, Susan Searles Nielsen, a research scientist in the department.

The investigation of dietary sources of nicotine stems from the puzzling epidemiologic findings that repeatedly show that people who have regularly used tobacco have about half the risk of developing Parkinson’s disease, explained Searles Nielsen. In 2012, she published a study that suggested that second-hand smoke also might reduce risk of the disease.

“It’s possible that people predisposed to Parkinson’s disease simply don’t respond well to tobacco smoke and therefore avoid it. However, if tobacco is actually protective, and if the reason is nicotine as some experimental studies suggest,” said Searles Nielsen, “then our hypothesis was that other plants in the Solanaceae family that contain nicotine might also be protective.”

The subjects interviewed for the study included 490 Parkinson’s patients newly diagnosed at the UW Neurology Clinic or Group Health Cooperative between 1992–2008. The control study subjects were 644 unrelated, neurologically normal people.

While she and the study co-authors investigated the association between Parkinson’s and the subjects’ dietary consumption of a variety of vegetables, including nicotine-containing peppers, tomatoes, and potatoes in the Solanaceae family, peppers showed the greatest protection. The decreased risk of disease grew stronger with increasing pepper consumption and occurred mainly in people with little or no prior use of tobacco, which contains much more nicotine than the foods studied.

Searles Nielsen cautions that further studies are needed to confirm these findings and explore whether a similar but less toxic chemical shared by peppers and tobacco might be equally or more protective than nicotine.

Study co-authors included department faculty Harvey Checkoway and Gary Franklin and W.T. Longstreth Jr. and Phillip Swanson from the Department of Neurology.

Funding for the study was provided by the National Institute of Environmental Health Sciences, in part through the University of Washington Superfund Research Program.

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