Kenneth Thummel, PhD

Chair, Pharmaceutics
Professor, Pharmaceutics (Primary department)
Adjunct Professor, Env. and Occ. Health Sciences
Kenneth Thummel received his Ph.D. in Pharmaceutical Science from the University of Washington in 1987 and completed a post-doctoral fellowship in Pharmacology at the University of Connecticut Health Science Center. In 1989, he was appointed to the University of Washington School of Pharmacy faculty, promoted to the rank of Professor in 2001, and was Associate Dean for Research & New Initiatives for the School of Pharmacy from 2003-06. He was appointed Chairman of the Department of Pharmaceutics in 2006 and currently holds the Milo Gibaldi Endowed Chair in Pharmaceutics. He is also an Adjunct Professor in the UW Department of Environmental and Occupational Health Sciences. Dr. Thummel's research interests include the elucidation of genetic, homeostatic and environmental factors that contribute to interindividual differences in xenobiotic biotransformation, in particular, intestinal cytochrome P450 3A-mediated first-pass drug metabolism. Dr. Thummel is a Fellow of the American Association for the Advancement of Science and the American Association of Pharmaceutical Scientists. He is a past Associate Editor for Drug Metabolism and Disposition and a member of the FDA Advisory Committee for Pharmaceutical Science and Clinical Pharmacology.

Affiliations

Research Interests

  • P450-dependent drug metabolism, inter-individual variability, CYP3A-mediated intestinal and hepatic first-pass drug metabolism, pharmacogenetics, vitamin D metabolism, drug-induced nephrotoxicity in transplantation, PBPK modeling of drug clearance.

Teaching interests

Pharmacokinetics/toxicokinetics, pharmacogenomics, drug-drug interactions, drug and xenobiotic metabolism, gene regulation

Education

PhD, Pharmaceutical Sciences, University of Washington, 1987
BS, Chemistry, Boise State University, 1981
BS, Pre Medicine, Boise State University, 1978

Projects

Pharmacogenetics for rural and under-served populations (Alaska Native and American Indian people in the Pacific Northwest)

CYP3A-dependent vitamin D metabolism and drug-induced osteomalacia

Obstetrics-fetal pharmacology research

Development of microphysiological models of renal, hepatic and intestinal drug disposition
Review date: 
12/9/2017