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University of Washington

Sheela Sathyanarayana

Sheela Sathyanarayana, MPH, MD
Assistant Professor, Pediatrics (Primary department)
Adjunct Assistant Professor, Env. and Occ. Health Sciences

Sheela Sathyanarayana, MD MPH, is an Assistant Professor of Pediatrics and Adjunct Assistant Professor within the Department of Environmental and Occupational Health Sciences at the University of Washington and an Investigator within the Center for Child Health, Behavior and Development at the Seattle Children's Research Institute. She is a pediatric environmental health specialist. Her research interests focus on exposures to endocrine disrupting chemicals including phthalates and bisphenol A and their impact on reproductive development. Currently, Dr. Sathyanarayana is the center director and clinical director for The Infant Development and Environment Study (TIDES) which is a multi-center cohort study of phthalate exposures in pregnancy and health outcomes in children. She is currently the co-chair for the US Environmental Protection Agency's Children's Health Protection Advisory Committee. Dr. Sathyanarayana performs environmental health consults for health care professionals, governmental entities, and individual families related to environmental exposures and children's health. She also practices general pediatrics at Harborview Medical Center in Seattle, Washington.

Contact Information

University of Washington Dept of Pediatrics
Office: Seattle Children's Hospital, CCHBD
Box: Box 5371
2001 8th Avenue
Seattle, WA 98121
Tel: 206-884-1037
Fax: 206-884-7803

Links

Affiliations

Research Interests

  • Environmental Endocrine Disruptors, Pediatric Environmental Health, Reproductive Toxicology, Birth defects

Teaching interests

ENV 515: TOXICOLOGY II
ENV 590A: REPRODUCTIVE TOXICOLOGY
ENV 570: ENVIRONMENTAL AND OCCUPATIONAL EPIDEMIOLOGY

Education

MPH, Epidemiology, University of Washington,
MD, Medicine (MD), University of Southern California,

Projects

Pediatric Environmental Health Specialty Unit

Provide training and education to other physicians and residents in training regarding the evidence base for environmental exposures and asthma and how to incorporate the evidence in to clinical practice.
Funder: CDC/EPA
Role: Co-Director

The Infant Development and Environment Study (TIDES)

TIDES is a multi-center (Seattle, WA, Minneapolis, MN, San Francisco, CA and Rochester, NY) cohort study of prenatal environmental exposures and infant reproductive outcomes. We will examine phthalate concentrations in first trimester urine samples in women in relation to intermediate reproductive phenotypes. The primary aims of TIDES are to: 1. Examine anogenital distance (males and females), penile width, and anoscrotal distance in relation to prenatal environmental phthalate exposures and 2. To establish population normative values for anogenital distance (males and females), anoscrotal distance, and penile width.
Funder: NIEHS
Role: Site PI, Clinical Director, Co-investigator

Genetics and the Environment Associated with Male Reproduction (GEAR)

GEAR will genotype candidate genes and repeat polymorphism length in 400 male infants recruited in relation to intermediate male reproductive phenotypes (anogenital distance, anoscrotal distance, and penile width). We will obtain and genotype buccal swab/FTA card DNA samples from infants during already scheduled birth exams in TIDES. We will first examine the association between genetic variation in AR, ESR1, ESR2, SRD5A2, ATF3, INSL3/LGR8, CTGF, CYR61 and shortened AGD and ASD, and smaller PW; then proceed to test whether this association is modified by first trimester urine phthalate exposures.
Funder: NIEHS
Role: PI

Selected Publications

Manuscripts in Refereed Journals

  1. Sathyanarayana S, Beaudet N, Omri K, Karr C. Predicting Children's Blood Lead Levels From Exposure to School Drinking Water in Seattle, Washington, USA. Ambul Pediatr. 2006 Sep-Oct;6(5):288-92.
  2. Sathyanarayana S, Karr C, Lozano P, Calafat A, Brown E, Liu F, Swan SH. Baby Care Products: Possible Sources of Infant Phthalate Exposure. Pediatrics. Feb. 2008.*
  3. Sathyanarayana S. Phthalates and Children’s Health. Current Problems in Pediatric and Adolescent Health Care. February. 2008
  4. Sathyanarayana S, Calafat AM, Liu F, Swan SH. Maternal and infant urinary phthalate metabolite concentrations: are they related? Environ Res. 2008 Nov;108(3):413-8. Epub 2008 Aug 19.
  5. Karr CJ, Rudra CB, Miller KA, Gould TR, Larson T, Sathyanarayana S, Koenig JQ. Infant exposure to fine particulate matter and traffic and risk of hospitalization for RSV bronchiolitis in a region with lower ambient air pollution. Environ Res. 2009 Apr;109(3):321-7. Epub 2009 Feb 10.
  6. Meeker JD, Sathyanarayana S, Swan SH. Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos Trans R Soc Lond B Biol Sci. 2009 Jul 27;364(1526):2097-113.
  7. Sathyanarayana S, Zhou C, Beard LA, Grady R. Measurement and Correlates of Anogenital Distance in Healthy, Newborn Infants. International Journal of Andrology. 2010 Jan:33(2): 317-323.
  8. Sathyanarayana S, Basso O, Karr C, Lozano PL, Alavanja M, Sandler D, Hoppin JA. Maternal Pesticide Use and Birth Weight in the Agricultural Health Study? Journal of Agromedicine, 2010 April:15(2): 127-136.
  9. Braun JM, Kalkbrenner AE, Calafat AM, Bernert JT, Ye X, Silva MJ, Barr DB, Sathyanarayana S, Lanphear BP. Variability and Predictors of Urinary Bisphenol A Concentrations during Pregnancy. Environ Health Perspect. 2011 Jan;119(1):131-7.
  10. Parker JD, Rich DQ, Glinianaia SV, Leem JH, Wartenberg D, Bell ML, Bonzini M, Brauer M, Darrow L, Gehring U, Gouveia N, Grillo P, Ha E, van den Hooven EH, Jalaludin B, Jesdale BM, Lepeule J, Morello-Frosch R, Morgan GG, Slama R, Pierik FH, Pesatori AC, Sathyanarayana S, Seo J, Strickland M, Tamburic L, Woodruff TJ. The International Collaboration on Air Pollution and Pregnancy Outcomes: Initial Results. Environ Health Perspect. 2011, February. doi:10.1289/ehp.1002725.
  11. Sathyanarayana S, Braun J, Yolton K, Liddy S, and Lanphear B. Case report: High Prenatal Bisphenol A Exposure and Infant Neonatal Neurobehavior. Environ Health Perspect . 2011 Aug; 119(8): 1170-5. Epub 2011 Apr 21.*
  12. Roth C and Sathyanarayana S. Mechanisms affecting neuroendocrine and epigenetic regulation of body weight and onset of puberty: potential implications in the child born small for gestational age (SGA). Rev Endoc Metabl Disord. 2012 Mar;120(3):a102-3. [Epub ahead of print]
  13. Sathyanarayana S, Focareta J, Dailey T, Buchanan S. Environmental Exposures: How to Counsel in the Prenatal Clinical Setting. Am J Obstet Gynecol. 2012 Feb 14. [Epub ahead of print]*
  14. Sathyanarayana S, Swan SH, Farin FM, Wilkerson HW, Bamshad M, Grady R, Zhou , Schwartz SM. A Pilot Study of the Association between Genetic Polymorphisms involved in Estrogen Signaling and Infant Male Genital Phenotypes. Asian Journal of Andrology. 2012 May 14. doi: 10.1038/aja.2012.27. [Epub ahead of print]. PMID: 22580635 [PubMed - as supplied by publisher].*
  15. Grady R, Sathyanarayana S. An Update on Phthalates and Male Reproductive Development and Function. Curr Urol Rep. 2012 Jun 22. [Epub ahead of print] PMID: 22723150 [PubMed - as supplied by publisher].
  16. Dadvand P, Parker J, Bell ML, Bonzini M, Brauer M, Darrow LA, Gehring U, Glinianaia SV, Gouveia N, Ha E, Leem JH, van den Hooven EH, Jalaludin B, Jesdale BM, Lepeule J, Morello-Frosch R, Morgan GG, Pesatori FH, Pless-Mulloli T, Rich DQ, Sathyanarayana S, Seo J, Slama R, Strickland M, Tamburic L, Wartenbern D, Nieuwenhuijsen MJ, Woodruff TJ. Maternal Exposure to Particulate Air Pollution and Term Birth Weight; A Multi-Country Ealuation of Effect and Heterogeneity. Environ Health Perspect. 2013 Feb 6. [Epub ahead of print] PMID: 23384584 [PubMed – as supplied by publisher].
  17. Sathyanarayana S, Rudra CB, Zhou C, Gould TR, Larson T, Koenig JQ, and Karr CJ. Prenatal Ambient Air Pollution Exposure and Small for Gestational Age Birth in the Puget Sound Air Basin. Air Qual, Atmos. & Health. Accepted. 2012 Aug.
  18. Braun J, Sathyanarayana S, Hauser R. Phthalate Exposure and Children's Health. Current Op in Pediatrics. Accepted. 2012 Dec.
  19. Sathyanarayana S, Alcedo G, Saelens B, Zhou C, Dills R, Yu J, Lanphear B. Unexpected Results in a Randomized Dietary Trial to Reduce Phthalate and Bisphenol A Exposures. J Expo Sci and Env Epi. Accepted. 2012 Dec.*
  20. Trasande L, Attina T, Sathyanarayana S, Spanier A, Blustein J. Race/Ethnicity-Specific Associations of Urinary Phthalates with Childhood Body Mass in a Nationally Representative Sample. Environ Health Perspect. Accepted 2013 Jan.
  21. Woodard DB, Love TMT, Thurston SW, Rupert D, Sathyanarayana S, Swan SH. Latent Factor Regression Models For Grouped Outcomes. Biometrics. Accepted 2013 Feb.

Book Chapters

None

Published books, videos, software.

American Academy of Pediatrics PREP Audio September 2013: Endocrine Disrupting Chemicals. Sathyanarayana S, Lee M, Galvez M.

Other publications

  1. Sathyanarayana S. Problem with Plastics. AAP News. American Academy of Pediatrics 2009 Aug;30(8):29.
  2. Berg J, Sathyanarayana S. Bisphenol A (BPA) Derivatives in Dental Resins Safe for Kids—When Precautions are Followed. AAP News. American Academy of Pediatrics. 2011 April.
Review date: 
5/21/2013