Pilot Project: Salivary Biomonitoring for Organophosphorus Pesticide Exposure in Children

(PNASH Pilot, 1999-2000) This project was designed to investigate the feasibility of measuring pesticide exposure using saliva in children. Conventional biomonitoring methods, such as blood and urine collections, have several, inherent practical limitations, which prohibit its application to large-scale studies or to studies involving sub-populations, such as children.  Saliva biomonitoring could provide a useful tool for researchers in determining not only the exposure to certain chemicals, such as pesticides, but the absorbed dose as well. A cohort of children who live in an agricultural community has been identified and recruited for this feasibility study. Saliva samples have been collected before and after the application of pesticides to fields close to their homes, and will be analyzed for pesticide residues.