About PTC

Center Overview

The Predictive Toxicology Center is funded by the United States Environmental Protection Agency (EPA) Science To Achieve Results (STAR) Program grant # 83573801. The Center is located within the University of Washington’s School of Public Health: Department of Environmental and Occupational Health Sciences and is administratively housed within the Institute for Risk Analysis and Risk Communication (IRARC).

PTC Organizational Structure
Predictive Toxicology Center Organizational Structure


The overall goal of this Center is to develop innovative organotypic culture systems to better evaluate the potential for cellular and organ toxicity following exposure to Metals and Engineered Nanomaterials (ENMs). We have designed four organotypic culture projects that reflect the complexity and function of the lung, kidney, liver and testis. Our center provides an academic research setting to further develop and integrate 3-D organotypic culture systems.  We have designed our Center using a framework to evaluate in vitro results for informing mechanistic research on adverse health endpoints (adverse outcome pathway, AOP). This exciting initiative from EPA will allow this Center to build on other research currently occurring at the University of Washington on ENMs.