Journal Articles 


Wang H, Zhang L, Abel GM, Storm DR, Xia Z. Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice. Toxicol Sci. 2018 Jan 1;161(1):87-102. doi: 10.1093/toxsci/kfx202. PubMed PMID: 29029324; PubMed Central PMCID: PMC5837361.

Engstrom AK, Xia Z. Lead exposure in late adolescence through adulthood impairs short-term spatial memory and the neuronal differentiation of adult-born cells in C57BL/6 male mice. Neurosci Lett. 2017 Nov 20;661:108-113. doi: 10.1016/j.neulet.2017.09.060. Epub 2017 Sep 29. PubMed PMID: 28970130; PubMed Central PMCID: PMC5671893.

Engstrom AK, Snyder JM, Maeda N, Xia Z. Correction to: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice. Mol Neurodegener. 2017 Nov 3;12(1):81. doi: 10.1186/s13024-017-0223-7. PubMed PMID: 29100536; PubMed Central PMCID: PMC5670524.

Xia Z, Storm D. Role of circadian rhythm and REM sleep for memory consolidation. Neurosci Res. 2017 May;118:13-20. doi: 10.1016/j.neures.2017.04.011. Epub 2017 Apr 20. Review. PubMed PMID: 28434990.

Wang H, Engstrom AK, Xia Z. Cadmium impairs the survival and proliferation of cultured adult subventricular neural stem cells through activation of the JNK and p38 MAP kinases. Toxicology. 2017 Apr 1;380:30-37. doi: 10.1016/j.tox.2017.01.013. Epub 2017 Feb 3. PubMed PMID: 28163110; PubMed Central PMCID: PMC5413202.

Choi WS, Kim HW, Tronche F, Palmiter RD, Storm DR, Xia Z. Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons. Sci Rep. 2017 Mar 22;7:44989. doi: 10.1038/srep44989. PubMed PMID: 28327638; PubMed Central PMCID: PMC5361188.

Engstrom AK, Snyder JM, Maeda N, Xia Z. Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice. Mol Neurodegener. 2017 Feb 7;12(1):14. doi: 10.1186/s13024-017-0155-2. PubMed PMID: 28173832; PubMed Central PMCID: PMC5297175.

Kim HW, Choi WS, Sorscher N, Park HJ, Tronche F, Palmiter RD, Xia Z. Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo. Neurobiol Aging. 2015 Sep;36(9):2617-27. doi: 10.1016/j.neurobiolaging.2015.05.008. Epub 2015 May 16. PubMed PMID: 26070241; PubMed Central PMCID: PMC4523431.

Engstrom A, Wang H, Xia Z. Lead decreases cell survival, proliferation, and neuronal differentiation of primary cultured adult neural precursor cells through activation of the JNK and p38 MAP kinases. Toxicol In Vitro. 2015 Aug;29(5):1146-55. doi: 10.1016/j.tiv.2015.05.001. Epub 2015 May 9. PubMed PMID: 25967738; PubMed Central PMCID: PMC4457670.

Wang W, Lu S, Li T, Pan YW, Zou J, Abel GM, Xu L, Storm DR, Xia Z. Inducible activation of ERK5 MAP kinase enhances adult neurogenesis in the olfactory bulb and improves olfactory function. J Neurosci. 2015 May 20;35(20):7833-49. doi: 10.1523/JNEUROSCI.3745-14.2015. PubMed PMID: 25995470; PubMed Central PMCID: PMC4438129.

Yu AK, Song L, Murray KD, van der List D, Sun C, Shen Y, Xia Z, Cortopassi GA. Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse. Hum Mol Genet. 2015 May 15;24(10):2848-60. doi: 10.1093/hmg/ddv045. Epub 2015 Feb 4. PubMed PMID: 25652399; PubMed Central PMCID: PMC4406296.

Zou J, Wang W, Pan YW, Abel GM, Storm DR, Xia Z. Conditional Inhibition of Adult Neurogenesis by Inducible and Targeted Deletion of ERK5 MAP Kinase Is Not Associated with Anxiety/Depression-Like Behaviors. eNeuro. 2015 Apr 16;2(2). pii: ENEURO.0014-14.2015. doi: 10.1523/ENEURO.0014-14.2015. eCollection 2015 Mar-Apr. PubMed PMID: 26464972; PubMed Central PMCID: PMC4596085.

Luo J, Chen X, Pan YW, Lu S, Xia Z, Storm DR. The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulb. PLoS One. 2015 Mar 25;10(3):e0122057. doi: 10.1371/journal.pone.0122057. eCollection 2015. PubMed PMID: 25807252; PubMed Central PMCID: PMC4373939.

Choi WS, Kim HW, Xia Z. JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death. Toxicology. 2015 Feb 3;328:75-81. doi: 10.1016/j.tox.2014.12.005. Epub 2014 Dec 9. PubMed PMID: 25496994; PubMed Central PMCID: PMC4308505.

Zou J, Wang W, Pan YW, Lu S, Xia Z. Methods to measure olfactory behavior in mice. Curr Protoc Toxicol. 2015 Feb 2;63:11.18.1-21. doi: 10.1002/0471140856.tx1118s63. PubMed PMID: 25645244; PubMed Central PMCID: PMC4339283.

Choi WS, Xia Z. Maneb-induced dopaminergic neuronal death is not affected by loss of mitochondrial complex I activity: results from primary mesencephalic dopaminergic neurons cultured from individual Ndufs4+/+ and Ndufs4-/- mouse embryos. Neuroreport. 2014 Dec 3;25(17):1350-5. doi: 10.1097/WNR.0000000000000271. PubMed PMID: 25275677; PubMed Central PMCID: PMC4213303.

Wang W, Pan YW, Zou J, Li T, Abel GM, Palmiter RD, Storm DR, Xia Z. Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory. J Neurosci. 2014 Feb 5;34(6):2130-47. doi: 10.1523/JNEUROSCI.3324-13.2014. PubMed PMID: 24501354; PubMed Central PMCID: PMC3913867.

Zou J, Storm DR, Xia Z. Conditional deletion of ERK5 MAP kinase in the nervous system impairs pheromone information processing and pheromone-evoked behaviors. PLoS One. 2013 Oct 9;8(10):e76901. doi: 10.1371/journal.pone.0076901. eCollection 2013. PubMed PMID: 24130808; PubMed Central PMCID: PMC3793934.

Pan YW, Storm DR, Xia Z. Role of adult neurogenesis in hippocampus-dependent memory, contextual fear extinction and remote contextual memory: new insights from ERK5 MAP kinase. Neurobiol Learn Mem. 2013 Oct;105:81-92. doi: 10.1016/j.nlm.2013.07.011. Epub 2013 Jul 18. PubMed PMID: 23871742; PubMed Central PMCID: PMC3782100.

Li T, Wang W, Pan YW, Xu L, Xia Z. A hydroxylated metabolite of flame-retardant PBDE-47 decreases the survival, proliferation, and neuronal differentiation of primary cultured adult neural stem cells and interferes with signaling of ERK5 MAP kinase and neurotrophin 3. Toxicol Sci. 2013 Jul;134(1):111-24. doi: 10.1093/toxsci/kft083. Epub 2013 Apr 5. PubMed PMID: 23564643; PubMed Central PMCID: PMC3693129.

Pan YW, Wang W, Xia Z. Assessment of adult neurogenesis in mice. Curr Protoc Toxicol. 2013 May;Chapter 12:Unit12.20. doi: 10.1002/0471140856.tx1220s56. PubMed PMID: 23670864; PubMed Central PMCID: PMC3683539.

Li T, Pan YW, Wang W, Abel G, Zou J, Xu L, Storm DR, Xia Z. Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb. PLoS One. 2013 Apr 22;8(4):e61948. doi: 10.1371/journal.pone.0061948. Print 2013. PubMed PMID: 23630619; PubMed Central PMCID: PMC3632513.

Wang W, Pan YW, Wietecha T, Zou J, Abel GM, Kuo CT, Xia Z. Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb. J Biol Chem. 2013 Jan 25;288(4):2623-31. doi: 10.1074/jbc.M112.401091. Epub 2012 Dec 5. PubMed PMID: 23223235; PubMed Central PMCID: PMC3554929.

Choi WS, Kim HW, Xia Z. Preparation of primary cultured dopaminergic neurons from mouse brain. Methods Mol Biol. 2013;1018:61-9. doi: 10.1007/978-1-62703-444-9_6. PubMed PMID: 23681617.

Pan YW, Storm DR, Xia Z. The maintenance of established remote contextual fear memory requires ERK5 MAP kinase and ongoing adult neurogenesis in the hippocampus. PLoS One. 2012;7(11):e50455. doi: 10.1371/journal.pone.0050455. Epub 2012 Nov 26. PubMed PMID: 23189204; PubMed Central PMCID: PMC3506604.

Pan YW, Kuo CT, Storm DR, Xia Z. Inducible and targeted deletion of the ERK5 MAP kinase in adult neurogenic regions impairs adult neurogenesis in the olfactory bulb and several forms of olfactory behavior. PLoS One. 2012;7(11):e49622. doi: 10.1371/journal.pone.0049622. Epub 2012 Nov 21. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/c8d48e05-6465-4b1c-963a-ccab25274fa7. PubMed PMID: 23185386; PubMed Central PMCID: PMC3504159.

Chen X, Xia Z, Storm DR. Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase. J Neurosci. 2012 Nov 7;32(45):15769-78. doi: 10.1523/JNEUROSCI.2180-12.2012. PubMed PMID: 23136416; PubMed Central PMCID: PMC3506261.

Xia Z, Storm DR. Role of signal transduction crosstalk between adenylyl cyclase and MAP kinase in hippocampus-dependent memory. Learn Mem. 2012 Aug 16;19(9):369-74. doi: 10.1101/lm.027128.112. Review. PubMed PMID: 22904367; PubMed Central PMCID: PMC3418765.

Pan YW, Zou J, Wang W, Sakagami H, Garelick MG, Abel G, Kuo CT, Storm DR, Xia Z. Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis. J Biol Chem. 2012 Jul 6;287(28):23306-17. doi: 10.1074/jbc.M112.344762. Epub 2012 May 29. PubMed PMID: 22645146; PubMed Central PMCID: PMC3390609.

Pan YW, Chan GC, Kuo CT, Storm DR, Xia Z. Inhibition of adult neurogenesis by inducible and targeted deletion of ERK5 mitogen-activated protein kinase specifically in adult neurogenic regions impairs contextual fear extinction and remote fear memory. J Neurosci. 2012 May 9;32(19):6444-55. doi: 10.1523/JNEUROSCI.6076-11.2012. PubMed PMID: 22573667; PubMed Central PMCID: PMC3363363.

Zou J, Pan YW, Wang Z, Chang SY, Wang W, Wang X, Tournier C, Storm DR, Xia Z. Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants. J Neurosci. 2012 Mar 21;32(12):4118-32. doi: 10.1523/JNEUROSCI.6260-11.2012. PubMed PMID: 22442076; PubMed Central PMCID: PMC3333842.

Choi WS, Palmiter RD, Xia Z. Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model. J Cell Biol. 2011 Mar 7;192(5):873-82. doi: 10.1083/jcb.201009132. PubMed PMID: 21383081; PubMed Central PMCID: PMC3051820.

Choi WS, Klintworth HM, Xia Z. JNK3-mediated apoptotic cell death in primary dopaminergic neurons. Methods Mol Biol. 2011;758:279-92. doi: 10.1007/978-1-61779-170-3_19. PubMed PMID: 21815073; PubMed Central PMCID: PMC3490420.

Choi WS, Abel G, Klintworth H, Flavell RA, Xia Z. JNK3 mediates paraquat- and rotenone-induced dopaminergic neuron death. J Neuropathol Exp Neurol. 2010 May;69(5):511-20. doi: 10.1097/NEN.0b013e3181db8100. PubMed PMID: 20418776; PubMed Central PMCID: PMC3061491.

Klintworth H, Garden G, Xia Z. Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release. Neurosci Lett. 2009 Oct 2;462(1):1-5. doi: 10.1016/j.neulet.2009.06.065. Epub 2009 Jun 25. PubMed PMID: 19559752; PubMed Central PMCID: PMC2796146.

Wang Z, Li V, Chan GC, Phan T, Nudelman AS, Xia Z, Storm DR. Adult type 3 adenylyl cyclase-deficient mice are obese. PLoS One. 2009 Sep 11;4(9):e6979. doi: 10.1371/journal.pone.0006979. PubMed PMID: 19750222; PubMed Central PMCID: PMC2735775.

Cundiff P, Liu L, Wang Y, Zou J, Pan YW, Abel G, Duan X, Ming GL, Englund C, Hevner R, Xia Z. ERK5 MAP kinase regulates neurogenin1 during cortical neurogenesis. PLoS One. 2009;4(4):e5204. doi: 10.1371/journal.pone.0005204. Epub 2009 Apr 13. PubMed PMID: 19365559; PubMed Central PMCID: PMC2664926.

Choi WS, Kruse SE, Palmiter RD, Xia Z. Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15136-41. doi: 10.1073/pnas.0807581105. Epub 2008 Sep 23. PubMed PMID: 18812510; PubMed Central PMCID: PMC2567505.

Faigle R, Liu L, Cundiff P, Funa K, Xia Z. Opposing effects of retinoid signaling on astrogliogenesis in embryonic day 13 and 17 cortical progenitor cells. J Neurochem. 2008 Aug;106(4):1681-98. doi: 10.1111/j.1471-4159.2008.05525.x. Epub 2008 Jun 28. PubMed PMID: 18564368; PubMed Central PMCID: PMC2581522.

Cai B, Xia Z. p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis. 2008 Jun;13(6):803-10. doi: 10.1007/s10495-008-0218-5. PubMed PMID: 18465250; PubMed Central PMCID: PMC2442769.

Wang Y, Liu L, Xia Z. Brain-derived neurotrophic factor stimulates the transcriptional and neuroprotective activity of myocyte-enhancer factor 2C through an ERK1/2-RSK2 signaling cascade. J Neurochem. 2007 Aug;102(3):957-66. PubMed PMID: 17630987.

DiRocco DP, Xia Z. Alpha males win again. Nat Neurosci. 2007 Aug;10(8):938-40. PubMed PMID: 17657234.

Klintworth H, Newhouse K, Li T, Choi WS, Faigle R, Xia Z. Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis. Toxicol Sci. 2007 May;97(1):149-62. Epub 2007 Feb 25. PubMed PMID: 17324951.

Cude K, Wang Y, Choi HJ, Hsuan SL, Zhang H, Wang CY, Xia Z. Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway. J Cell Biol. 2007 Apr 23;177(2):253-64. PubMed PMID: 17452529; PubMed Central PMCID: PMC2064134.

Wang Y, Su B, Xia Z. Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade. J Biol Chem. 2006 Nov 24;281(47):35965-74. Epub 2006 Sep 26. PubMed PMID: 17003042.

Cai B, Chang SH, Becker EB, Bonni A, Xia Z. p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem. 2006 Sep 1;281(35):25215-22. Epub 2006 Jul 3. PubMed PMID: 16818494.

Liu L, Cundiff P, Abel G, Wang Y, Faigle R, Sakagami H, Xu M, Xia Z. Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9697-702. Epub 2006 Jun 9. PubMed PMID: 16766652; PubMed Central PMCID: PMC1480469.

Hsuan SL, Klintworth HM, Xia Z. Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. J Neurosci. 2006 Apr 26;26(17):4481-91. PubMed PMID: 16641227.

Tang X, Wang X, Gong X, Tong M, Park D, Xia Z, Mao Z. Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. J Neurosci. 2005 May 11;25(19):4823-34. PubMed PMID: 15888658.

Xia Z, Storm DR. The role of calmodulin as a signal integrator for synaptic plasticity. Nat Rev Neurosci. 2005 Apr;6(4):267-76. Review. PubMed PMID: 15803158.

Newhouse K, Hsuan SL, Chang SH, Cai B, Wang Y, Xia Z. Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells. Toxicol Sci. 2004 May;79(1):137-46. Epub 2004 Feb 19. PubMed PMID: 14976342.

Chang SH, Poser S, Xia Z. A novel role for serum response factor in neuronal survival. J Neurosci. 2004 Mar 3;24(9):2277-85. PubMed PMID: 14999078.

Caughlan A, Newhouse K, Namgung U, Xia Z. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicol Sci. 2004 Mar;78(1):125-34. Epub 2003 Dec 22. PubMed PMID: 14691213.

Liu L, Cavanaugh JE, Wang Y, Sakagami H, Mao Z, Xia Z. ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8532-7. Epub 2003 Jun 25. PubMed PMID: 12826611; PubMed Central PMCID: PMC166263.

Poser S, Impey S, Xia Z, Storm DR. Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP. J Neurosci. 2003 Jun 1;23(11):4420-7. PubMed PMID: 12805282.

Namgung U, Kim DH, Lim SR, Xia Z. Blockade of calcium entry accelerates arsenite-mediated apoptosis in rat cerebellar granule cells. Mol Cells. 2003 Apr 30;15(2):256-61. PubMed PMID: 12803490.

Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z. ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons. J Biol Chem. 2002 Dec 20;277(51):49577-84. Epub 2002 Oct 21. PubMed PMID: 12393899.

Ghahremani MH, Keramaris E, Shree T, Xia Z, Davis RJ, Flavell R, Slack RS, Park DS. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. J Biol Chem. 2002 Sep 20;277(38):35586-96. Epub 2002 Jun 28. PubMed PMID: 12091388.

Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. J Biol Chem. 2002 Jun 21;277(25):22909-14. Epub 2002 Apr 10. PubMed PMID: 11948180.

Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron. 2002 Apr 11;34(2):221-33. PubMed PMID: 11970864.

Xia Z, Storm DR. CaRF: a neuronal transcription factor that CaREs. Neuron. 2002 Jan 31;33(3):315-6. PubMed PMID: 11832218.

Mabuchi T, Kitagawa K, Kuwabara K, Takasawa K, Ohtsuki T, Xia Z, Storm D, Yanagihara T, Hori M, Matsumoto M. Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo. J Neurosci. 2001 Dec 1;21(23):9204-13. PubMed PMID: 11717354.

Namgung U, Xia Z. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicol Appl Pharmacol. 2001 Jul 15;174(2):130-8. PubMed PMID: 11446828.

Figueroa-Masot XA, Hetman M, Higgins MJ, Kokot N, Xia Z. Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation. J Neurosci. 2001 Jul 1;21(13):4657-67. PubMed PMID: 11425893.

Chan GC, Lernmark U, Xia Z, Storm DR. DNA elements of the type 1 adenylyl cyclase gene locus enhance reporter gene expression in neurons and pinealocytes. Eur J Neurosci. 2001 Jun;13(11):2054-66. PubMed PMID: 11422446.

Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z. Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. J Neurosci. 2001 Jan 15;21(2):434-43. PubMed PMID: 11160424.

Poser S, Impey S, Trinh K, Xia Z, Storm DR. SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation. EMBO J. 2000 Sep 15;19(18):4955-66. PubMed PMID: 10990459; PubMed Central PMCID: PMC314219.

Namgung U, Xia Z. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J Neurosci. 2000 Sep 1;20(17):6442-51. PubMed PMID: 10964950.

Wong ST, Trinh K, Hacker B, Chan GC, Lowe G, Gaggar A, Xia Z, Gold GH, Storm DR. Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron. 2000 Sep;27(3):487-97. PubMed PMID: 11055432.

Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol. 2000 Jul 24;150(2):335-47. PubMed PMID: 10908576; PubMed Central PMCID: PMC2180235.

Hetman M, Cavanaugh JE, Kimelman D, Xia Z. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. J Neurosci. 2000 Apr 1;20(7):2567-74. PubMed PMID: 10729337.

Hetman M, Xia Z. Signaling pathways mediating anti-apoptotic action of neurotrophins. Acta Neurobiol Exp (Wars). 2000;60(4):531-45. Review. PubMed PMID: 11200182.

Hetman M, Kanning K, Cavanaugh JE, Xia Z. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem. 1999 Aug 6;274(32):22569-80. PubMed PMID: 10428835.

Yue TL, Ni J, Romanic AM, Gu JL, Keller P, Wang C, Kumar S, Yu GL, Hart TK, Wang X, Xia Z, DeWolf WE Jr, Feuerstein GZ. TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease. J Biol Chem. 1999 Jan 15;274(3):1479-86. PubMed PMID: 9880523.

Xing J, Kornhauser JM, Xia Z, Thiele EA, Greenberg ME. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol. 1998 Apr;18(4):1946-55. PubMed PMID: 9528766; PubMed Central PMCID: PMC121424

Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science. 1997 Aug 1;277(5326):693-6. PubMed PMID: 9235893.

Xia Z, Storm DR. Calmodulin-regulated adenylyl cyclases and neuromodulation. Curr Opin Neurobiol. 1997 Jun;7(3):391-6. Review. PubMed PMID: 9232797.

Xia Z, Dudek H, Miranti CK, Greenberg ME. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J Neurosci. 1996 Sep 1;16(17):5425-36. PubMed PMID: 8757255.

Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 1995 Nov 24;270(5240):1326-31. PubMed PMID: 7481820.

Wu ZL, Thomas SA, Villacres EC, Xia Z, Simmons ML, Chavkin C, Palmiter RD, Storm DR. Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):220-4. PubMed PMID: 7816821; PubMed Central PMCID: PMC42849.

Xia Z, Choi EJ, Blazynski C, Storn DR. Do the Calmodulin Stimulated Adenylyl Cyclases Play a Role in Neuroplasticity?. Behavioral and Brain Science. 1995; 18(3):429-440.

Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR. Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase. Genomics. 1993 May;16(2):473-8. PubMed PMID: 8314585.

Choi EJ, Xia Z, Villacres EC, Storm DR. The regulatory diversity of the mammalian adenylyl cyclases. Curr Opin Cell Biol. 1993 Apr;5(2):269-73. Review. PubMed PMID: 8507499.

Villacres VC, Xia Z, Choi EJ, Storm DR. Calmodulin Regulation of Mammalian Adenylyl Cyclases. Current Topics in Molecular Pharmacology. 1993; 1:51-54.

Xia Z, Choi EJ, Wang F, Blazynski C, Storm DR. Type I calmodulin-sensitive adenylyl cyclase is neural specific. J Neurochem. 1993 Jan;60(1):305-11. PubMed PMID: 8417150.

Xia Z, Choi EJ, Wang F, Storm DR. The type III calcium/calmodulin-sensitive adenylyl cyclase is not specific to olfactory sensory neurons. Neurosci Lett. 1992 Sep 14;144(1-2):169-73. PubMed PMID: 1436697.

Choi EJ, Xia Z, Storm DR. Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin. Biochemistry. 1992 Jul 21;31(28):6492-8. PubMed PMID: 1633161.

Xia ZG, Refsdal CD, Merchant KM, Dorsa DM, Storm DR. Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain: expression in areas associated with learning and memory. Neuron. 1991 Mar;6(3):431-43. PubMed PMID: 2001286.

Tota MR, Xia ZQ, Storm DR, Schimerlik MI. Reconstitution of muscarinic receptor-mediated inhibition of adenylyl cyclase. Mol Pharmacol. 1990 Jun;37(6):950-7. PubMed PMID: 2113606.

Xia ZG, Storm DR. A-type ATP binding consensus sequences are critical for the catalytic activity of the calmodulin-sensitive adenylyl cyclase from Bacillus anthracis. J Biol Chem. 1990 Apr 25;265(12):6517-20. PubMed PMID: 2108958.

Xia Z, Zhu R, Cao X, Zou G. Purification and characterization of restriction endonuclease Bsp 78I. Acta Biochimica et Biophysica Sinica (Chinese). 1987; 19:27-34


Books and Chapters

Xia Z. Wiley Encyclopedia of Molecular Medicine. Creighton TA, editor. USA: John Wiley; 2002. Adenylyl cyclases 79-82p
Xia Z, Storm DR. Molecular Biology Intelligence Unit.. USA: R.G. Landes; 1996. The Mammalian Adenylyl Cyclases