Drug-sensitive (halo) and drug-resistant (no halo) forms of the environmental pathogen Mycobacterium avium
Mycobacterium tuberculosis, a globally important microbial pathogen, and related environmental mycobacteria (non-tuberculous mycobacteria, or NTM), are useful models for understanding how infectious respiratory diseases emerge and spread.
We pioneered the application of real-time molecular epidemiology in direct support of tuberculosis outbreak control efforts. More recently, we published extensively cited findings on 1) person-to-person spread of M. abscessus among cystic fibrosis patients; and 2) community-based case-control analyses of risk factors for pulmonary M. avium complex (MAC) disease in HIV-negative adults.
Association studies conducted by our laboratory implicate shower aerosols as uniquely significant sources of non-tuberculous mycobacteria (NTM) infection in Washington and Oregon (see Tzou et al, 2020).
1Some case-control pairs had more than one control. Positives were samples with at least NTM isolate.
2Adjusted for age over 80 years
3Adjusted for age, race, and education level
Tzou CL, Dirac MA, Becker AL, Beck NK, Weigel KM, Meschke JS, and Cangelosi GA (2020). Association between Mycobacterium avium complex pulmonary disease and mycobacteria in home water and soil: A case-control study. Ann Am Thorac Soc. 17:57-62. PMID: 31644315.
Dirac MA, Horan KL, Doody DR, Meschke JS, Park DR, Jackson LA, Weiss NS, Winthrop KL, Cangelosi GA (2012). Environment or host?: A case-control study of risk factors for Mycobacterium avium complex lung disease. Am J Respir Crit Care Med. Oct 1;186(7):684-91. PMID: 22859521
Aitken ML, Limaye A, Pottinger P, Whimbey E, Goss CH, Tonelli MR, Cangelosi GA, Ashworth-Dirac M, Olivier KN, Brown-Elliot BA, McNulty S, and Wallace RJ (2012). Respiratory Outbreak of Mycobacterium abscessus Subspecies massiliense in a Lung Transplant and Cystic Fibrosis Center. Am. J. Respir. Crit. Care Med. 185: 231-232. PMID: 22246710
Ashworth M, Horan KL, Freeman R, Oren E, Narita M, and Cangelosi GA (2008). Use of PCR-based Mycobacterium tuberculosis genotyping to prioritize tuberculosis outbreak control activities. J Clin Microbiol 46(3):856-62. PMID: 18174293