Terrance J. Kavanagh, PhD, MS

Professor, Env. and Occ. Health Sciences (Primary department)
Adjunct Professor, Pulmonary and Critical Care Medicine

Contact Information

Box: 354695
4225 Roosevelt Way NE
Seattle, WA 98105-6099
Tel: 206-685-8479

Research Interests

  • Glutathione metabolism, analytical cytology, in vitro toxicology, transgenic models, toxicology of reactive oxygen/nitrogen species, toxicogenomics, nanotoxicology, systems toxicology
  • KEYWORDS: Air pollution, Bioactivation/Carcinogenesis, Biomarkers, Cardiovascular disease, Developmental toxicology, Genetic susceptibility to toxicants, Immunotoxicology, Liver toxicology, Nanotechnology, Renal toxicology, Respiratory toxicology, Risk assessment, Toxicology and aging, Xenobiotic metabolism

Education

PhD, Environmental Toxicology and Genetics, Michigan State University, 1985
MS, Physiology, Michigan State University, 1980

Projects

Glutathione (GSH) is an important endogenous antioxidant that has roles in free radical scavenging, protecting against reactive oxygen/nitrogen species and in the metabolism/excretion of xenobiotics. Our laboratory has established in vitro and in vivo transgenic mouse models of altered glutathione (GSH) synthesis. We are using these mice to investigate the effects of altered GSH synthesis on susceptibility to various exposures including air pollutants, engineered nanomaterials, and various drugs and environmental chemicals. We are also interested in the role of GSH synthesis in individual susceptibility of humans to free radical and toxicant-mediated injury. We are conducting studies to determine the effects of genetically altered GSH synthesis on cellular susceptibility to toxicant-induced DNA, protein and lipid damage, cell signaling and apoptosis. We are also interested in the factors that regulate the expression of GSH related genes in humans, rodents and other species.

Multiple sources of air pollutants such as industrial processes, automobile traffic, forest fires or indoor cooking fires continue to plague human society, resulting in adverse effects on the respiratory system, the cardiovascular system, the central nervous system, and on growth and development. Working with Drs. Joel Kaufman and Michael Rosenfeld, we are investigating the adverse effects of diesel exhaust and particulate matter on lung function, vascular reactivity and the development and stability of atherosclerotic lesions in mice. This project is employing a model of enhanced sensitivity to oxidative stress (Gclm null mice), genetically diverse mice (the Collaborative Cross mouse strains), as well as mouse and human vascular endothelial cells and macrophages to examine the biochemical and cellular mechanisms underlying the adverse cardiovascular outcomes associated with exposure to air pollution.
Nanotechnology holds promise for advancement in many disciplines, including electronics, optronics, energy, transportation, biomedicine and other sectors. Because of their small size and inherent high surface area/reactivity, or because the materials used to synthesize nanoparticles can be toxic, we have been interested in helping to define which physical and chemical characteristics of engineered nanomaterials (ENMs) predispose to toxicity and adverse health outcomes. Together with Drs. David Eaton, Elaine Faustman, Michael Yost (DEOHS), William Parks (Pulmonary Medicine and UW Center for Lung Biology), Xiaohu Gao (Bioengineering) and François Baneyx (Chemical Engineering and UW Center for Nanotechnology), we are participants in the NIEHS Centers for Nanotechnology Health Implications Research (NCNHIR) Consortium. This program is using in vitro toxicology, in vivo toxicology (including systems toxicology/mouse genetics), and risk assessment approaches to investigate the adverse effects of ENMs with the goals of elucidating the mechanisms by which they cause toxicity and inflammation, and using this mechanistic information to facilitate the design of safer ENMs.

In addition to the above projects, Dr. Kavanagh is Deputy Director of the Center for Ecogenetics and Environmental Health (CEEH), and oversees its Pilot Projects Program, and the CEEH Technology Access Unit. He also directs the CEEH Analytical Cytology Core. This facility houses two fluorescence activated cell sorters, a spectral imaging microscope, and a Nipkow-disk confocal microscope, which are useful for multi-parameter quantitative fluorescence measurements on cells and tissues.
Selected Publications

Research Papers in Refereed Journals

(*indicates research conducted by students, post-docs or staff under Dr. Kavanagh's supervision)

  1. Chen, T.H., T.J. Kavanagh, C.C. Chang and J.E. Trosko (1984). Inhibition of metabolic cooperation in Chinese hamster V79 cells by various organic solvents and simple compounds. J. Cell Biol. Toxicol. 1:155-171.
  2. Kavanagh, T.J., C. Rubenstein, P.L. Liu, C.C. Chang and J.E. Trosko (1985). Failure to induce mutations in Chinese hamster V79 cells and WB rat liver cells by the polybrominated biphenyls, Firemaster BP-6, 2,2',4,4',5,5'-hexabromobiphenyl, 3,3',4,4',5,5'-hexabromobiphenyl, and 3,3',4,4'-tetrabromobiphenyl. Toxicol. Appl. Pharmacol. 79:91-98.
  3. Kavanagh, T.J., C.C. Chang and J.E. Trosko (1986). Characterization of a human teratocarcinoma cell based assay for inhibitors of metabolic cooperation. Cancer Res. 46:1359-1366.
  4. Zhong-Xiang, L., T.J. Kavanagh, J.E. Trosko and C.C. Chang (1986). Inhibition of gap junctional intercellular communication in human teratocarcinoma cells by organochlorine pesticides. Toxicol. Appl. Pharmacol. 83:10-19.
  5. Kavanagh, T.J., C.C. Chang and J.E. Trosko (1987). The effect of polybrominated biphenyls, Firemaster BP-6, 2,2',4,4',5,5'-hexabromobiphenyl, 3,3',4,4',5,5'-hexabromobiphenyl, and 3,3',4,4'-tetrabromobiphenyl on cell-cell communication in cultured human teratocarcinoma cells. Fund. Appl.Toxicol., 8:127-31.
  6. Kavanagh, T.J., P.S. Rabinovitch, M. El-Fouly, C.C. Chang, J.E. Trosko and G.M. Martin (1987). Use of Scrape-loading/dye transfer and flow cytometry as a rapid quantitative measure of intercellular communication in vitro. Cancer Res. 47:6046-51.
  7. Kavanagh, T.J., G.M. Martin, J.C. Livesey and P.S. Rabinovitch (1988). Direct evidence for intercellular sharing of glutathione via metabolic cooperation. J. Cell. Physiol. 137:353-359.
  8. Kavanagh, T.J., A. Grossmann, E.P. Jaecks, J.C. Jinneman, D.L. Eaton, G.M. Martin, and P.S. Rabinovitch (1990). The proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content. J. Cell. Physiol. 145:472-480.
  9. Jenner, N.K., G.K. Ostrander, T.J. Kavanagh, J.C. Livesey, M.W. Shen, S.C. Kim and E.H. Holmes (1990). A flow cytometric comparison of DNA content and glutathione levels in hepatocytes of English sole (Parophrys vetulus) from areas of differing water quality. Arch. Env. Contam. Toxicol. 19:807-815.
  10. Poot, M., T.J. Kavanagh, H.C. Kang, R.P. Haugland and P.S. Rabinovitch (1991). Flow cytometric analysis of cell cycle-dependent changes in cell thiol level by combining a new laser dye with Hoechst 33342. Cytometry 12:184-187
  11. Kanner, S.B., T.J. Kavanagh, A. Grossmann, S.L. Hu, J.B. Bolen, P.S. Rabinovitch and J.A. Ledbetter (1992). Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylaton of phospholipase Cg1. PNAS 89:300-304.
  12. Siminski, J.T., T.J. Kavanagh and G. Raghu (1992). Maintenance of normal parenchyma in isolated lung organ culture for nine weeks in serum free conditions. Amer J. Physiol: Lung Cell. Mol. Physiol, 262:L105-L110.
  13. Kavanagh, T.J., A. Grossmann, J.C. Jinneman, S.B. Kanner, C.C. White, D.L. Eaton, J.A. Ledbetter and P.S. Rabinovitch (1993). The effect of 1-chloro-2,4-dinitrobenzene exposure on antigen receptor (CD3)-stimulated transmembrane signal transduction in purified subsets of human peripheral blood lymphocytes. Toxicol. Appl. Pharmacol. 119:91-99.
  14. Sidhu, J.S., T.J. Kavanagh, M.T. Reilly and C.J. Omiecinski (1993). Direct determination of functional activity of cytochrome P4501A1 and NADPH DT-diaphorase in hepatoma cell lines using non-invasive scanning laser cytometry. J. Toxicol. Env. Health. 40:177-194.
  15. Kavanagh, T.J., G. Raghu, C.C. White, G.M. Martin, P.S. Rabinovitch and D.L. Eaton (1994).
    Enhancement of glutathione content in glutathione synthetase-deficient fibroblasts from a patient with 5-oxoprolinuria via metabolic cooperation with normal fibroblasts. Exp. Cell Res. 212:69-76.
  16. Kuijpers, T.W., M. Reilly, T. Kavanagh, H. Janssen, J. Calafat, D. Roos and J.M. Harlan (1994). Cytokine-activated endothelial cells internalize E-selectin into a lysosomal compartment of vesiculotubular shape: A tubulin-driven process. J. Immunol. 152:5060-5069.
  17. Ponce R.A., T.J. Kavanagh, N.K. Mottet, S.G. Whittaker and E.M. Faustman (1994). Effect of methylmercury on cell cycle of primary rat CNS cells in vitro. Toxicol. Appl. Pharmacol. 127:83-90.
  18. Sidhu, J.S., F.M. Farin, T.J. Kavanagh and C.J. Omiecinski (1994). Effect of tissue culture substratum and extracellular matrix (ECM) overlay on liver selective and xenobiotic inducible gene expression in primary rat hepatocytes. In Vitro Toxicol. 7:225-242.
  19. Grossmann, A., P.S. Rabinovitch, T.J. Kavanagh, J.C. Jinneman, L.K. Killiland, J.A. Ledbetter and S.B. Kanner (1994) Activation of murine T-cells via phospholipase-Cg1-associated protein tyrosine phosphorylation is reduced with aging. J. Gerontology 50A:B205-B212.
  20. Ogburn, C.E., M.S. Turker, T.J. Kavanagh, C.M. Disteche, A.C. Smith, K.I. Fukuchi and G.M. Martin (1994). Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator phenotypes. Somat. Cell Mol. Genet. 20:361-70
  21. Poot, M., H. Teubert, P.S. Rabinovitch and T.J. Kavanagh (1995). De novo synthesis of glutathione is required for both entry into and progression through the cell cycle. J. Cell. Physiol. 163:555-560
  22. Iruela-Arispe, M.L., T.F. Lane, D. Redmond, M. Reilly, R.P Bolender, T.J. Kavanagh and E.H. Sage (1995). Expression of SPARC during vascular development of the chicken chorioallantoic membrane: Evidence that proteolysis releases angiogenic peptides. Mol. Biol. Cell 6:327-343.
  23. Tsuchiya, K., R.T. Mulcahey, L.L. Reid, C.M. Disteche and T.J. Kavanagh (1995). Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E, and the regulatory subunit gene (GCLCR) to human chromosome 1p21-p22 and mouse chromosome 3H-1-3. Genomics 30:630-632.
  24. Poot, M., F.N. Hudson, A. Grossmann, P.S. Rabinovitch and T.J. Kavanagh (1995). Probenicid inhibition of fluorescence extrusion after MCB-staining of rat-1 fibroblasts. Cytometry 23:78-81.
  25. Kovacs, K., T.J. Kavanagh and L.G. Costa (1995). Ethanol inhibits muscarinic receptor-stimulated phosphoinositide metabolism and calcium mobilization in rat primary cortical cultures. Neurochem. Res. 20:939-949.
  26. Heinonen, J.T., J.S. Sidhu, M.T. Reilly, F.M. Farin, C.J. Omiecinski, D.L. Eaton and T.J. Kavanagh (1996). Assessement of regional cytochorome P450 activities in rat liver slices using resorufin substrates and fluorescence confocal laser cytometry. Environ. Health Perspect. 104:536-543
  27. Sopher, B.L., K.I. Fukuchi, T.J. Kavanagh, C.E. Furlong and G.M. Martin (1996). Neurodegenerative mechanisms in Alzheimer's disease: A role for oxidative damage in amyloid b protein precursor-mediated cell death. Mol. Chem. Neuropath. 29:153-168.
  28. Li, S., S.A. Thompson, T.J. Kavanagh and J.S. Woods (1996). Localization by in situ hybridization of g-glutamylcysteine synthetase mRNA expression in rat kidney following acute methyl mercury treatment. Toxicol. Appl. Pharmacol. 141:59-67
  29. Krejsa, C.M., S.G. Nadler, J.M. Esselstyn, T.J. Kavanagh, J.A. Ledbetter and G.L. Schieven (1997). Role of oxidative stress in the action of vanadium phosphotyrosine phosphotase inhibitors: Redox independent activation of NF-kB. J. Biol. Chem. 272:11541-11549
  30. Potter, A.J., A. Grossmann, P.S. Rabinovitch, D.L. Eaton and T.J. Kavanagh (1997). The effect of in vitro phorone exposure on glutathione content and T-cell antigen receptor stimulated calcium mobilization in murine splenic T lymphocytes. Toxicol. In Vitro 11:355-363.
  31. Reid, L.L., D. Botta, Y. Lu, E.P. Gallagher and T. J. Kavanagh (1997). Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase. Biochim. Biophys. Acta. 1352: 233-237
  32. Reid, L.L., D. Botta, J. Shao, F.N. Hudson and T.J. Kavanagh (1997). Molecular cloning and sequencing of the cDNA encoding mouse glutamate-cysteine ligase regulatory subunit. Biochim. Biophys. Acta. 1353:107-110.
  33. Ou, Y. C., S. A. Thompson, S. C. Kirchner, T. J. Kavanagh and E. M. Faustman (1997). Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury. Toxicology And Applied Pharmacology 147: 31-38.
  34. Calverley, D.C., T.J. Kavanagh and G.J. Roth. (1998). Human signaling protein 14-3-3 zeta interacts with platelet glycoprotein Ib subunits Ib alpha and Ib beta. Blood 91:1295-1303.
  35. Broudy, V.C., N.L. Lin, H.J. Bühring, N. Komatsu and T.J. Kavanagh (1998). Analysis of c-Kit receptor dimerization by fluorescence resonance energy transfer. Blood 91:898-906.
  36. Thompson, SA, K.L. Roellich, A. Grossmann, S.G. Gilbert and T.J. Kavanagh (1998). Alterations in immune parameters associated with low level methylmercury exposure in mice. Immunopharmacology and Immunotoxicology 20:299-314.
  37. Ponce, R.A, S.M. Bartell, T.J. Kavanagh, J.S. Woods, W.C. Griffith, R.C. Lee, T.K. Takaro and E.M. Faustman (1998). Uncertainty analysis methods for comparing predictive models and biomarkers: A case study of dietary methylmercury exposure. Reg. Toxicol. Pharmacol. 28, 96–105.
  38. Nelson, K.C., Diaz, D., Kavanagh, T.J. Sternberg P Jr, and Jones, D.P. (1999). Effect of dietary inducer dimethylfumarate on glutathione in cultured retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 40:1927-35
  39. Ou Y.C., Thompson, S.A., Ponce, R.A., Schroeder, J., Kavanagh, T.J. and Faustman, E.M. (1999). Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicol Appl Pharmacol 157:203-12.
  40. Woods, J.S., Kavanagh, T.J., Correl, J., Reese, A.W., Diaz, D., and Ellis, M.E. (1999). The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained up-regulation of glutathione biosynthesis. Toxicol Appl. Pharmacol 160:207-216.
  41. Oram, J.F., Mendez, A.J., Lymp, J., Kavanagh, T.J., and Halbert, C.L. (1999). Reduction in apolipoprotein-mediated removal of cellular lipids by immortalization of human fibroblasts and its reversion by cAMP. Lack of effect with Tangier disease cells. J. Lipid Res. 40:1769-81.
  42. Thompson, S.A., White, C.C., Krejsa, C.M., Diaz, D., Woods, J.S., Eaton, D.L. and Kavanagh, T.J. (1999). Induction of glutamate-cysteine ligase (g-glutamylcysteine synthetase) in the brains of adult female mice sub-chronically exposed to methylmercury. Toxicol. Lett. 110:1-9.
  43. Ou, Y.C., White, C.C., Krejsa, C.M., Ponce, R.A., Kavanagh, T.J. and Faustman, E.M. (1999). The Role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. Neurotoxicology 20:793-784.
  44. Kirlin, W.G., Cai, J., Thompson, S.A., Diaz, D., Kavanagh, T.J. and Jones, D.P. (1999). Glutathione redox potential in response to differentiation and enzyme inducers. Free Rad Biol Med 27:1208-1218.
  45. Siitonen T., Alaruikka P., Mantymaa P., Savolainen E.R., Kavanagh T.J., Krejsa C.M., Franklin C.C., Kinnula V.and Koistinen P. (1999) Protection of acute myeloblastic leukemia cells against apoptotic cell death by high glutathione and gamma-glutamylcysteine synthetase levels during etoposide-induced oxidative stress. Ann Oncol 10:1361-7.
  46. Rochon, Y.P., Kavanagh, T.J. and Harlan J.M. (2000). Analysis of integrin (CD11b/CD18) movement during neutrophil adhesion and migration on endothelial cells. J Microsc 197:15-24.
  47. Jarvinen, K., Pietarinen-Runtti, P., Linnainmaa, K., Raivio, K.O., Krejsa, C.M., Kavanagh, T. and Kinnula, V.L. (2000). Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells. Amer. J Physiol Lung Cell Mol Physiol 278:L696-702.
  48. Pierce, R.H., Campbell, J.S., Stephenson, A.B., Franklin, C.C., Chaisson, M., Poot, M., Rabinovitch, P.S., Kavanagh, T.J. and Fausto, N. (2000). Disruption of redox homeostasis in tumor necrosis factor induced apoptosis in murine hepatocytes. Am. J. Pathol. 157:221-36
  49. Hudson, F.N. and Kavanagh, T.J.(2000). Cloning and characterization of the proximal promoter region of the mouse glutamate-L-cysteine ligase regulatory subunit gene. Biochim. Biophys. Acta. 1492:447-451.
  50. Thompson, S.A., White, C.C., Krejsa, C.M., Eaton, D.E. and Kavanagh, T.J. (2000). Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development. Toxicol. Sci. 57:141-6
  51. Catlin M.C., Kavanagh T.J. and Costa L.G. (2000). Muscarinic receptor-induced calcium responses in astroglia. Cytometry 41:123-132.
  52. Diaz, D., Krejsa, C.M., White, C.C., Keener, K.L., Farin F.M. and Kavanagh, T.J. (2001). Tissue specific changes in the expression of glutamate-cysteine ligase mRNAs in mice exposed to methylmercury. Toxicol Lett. 122:119-29.
  53. Diaz, D., Krejsa, C.M. and Kavanagh, T.J. (2001). Localization of glutamate-cysteine ligase mRNA and protein in mouse kidney and induction with methylmercury. Toxicol. Lett. 123:33-41
  54. Luderer, U., Kavanagh, T.J., White*, C.C. and Faustman, E.M. (2001). Gonadotropin regulation of glutathione synthesis in the rat ovary. Reprod. Toxicol. 15:495-504
  55. Rosatto, M.J., Jabbour A.J., Ponce, R.A., Kavanagh, T.J., Takaro, T.K., Hill, J.P., Poot, M., Rabinovitch, P.S. and Faustman, E.M. (2001). Simultaneous analysis of surface marker expression and cell cycle progression in human peripheral blood mononuclear cells. J. Immunol. Meth. 256:35-46
  56. Adams, M.L., Pierce, R.H., Vail, M.E. , White*, C.C., Tonge, R.P., Kavanagh, T.J., Fausto, N., Nelson, S.D. and Bruschi, S.A. (2001). Enhanced Acetaminophen Hepatotoxicity in Transgenic Mice Overexpressing BCL-2. Mol. Pharmacol. 60:1-9
  57. Diaz*, D., Krejsa*, C.M. and Kavanagh, T.J. (2002). Expression of glutamate-cysteine ligase during mouse development. Mol. Reprod. Dev. 62:83-91
  58. Franklin C.C., Krejsa*, C.M., Pierce, R.H., White*, C.C., Fausto N. and Kavanagh T.J. (2002). Caspase-3-dependent cleavage of the glutamate-L-cysteine ligase catalytic subunit during apoptotic cell death. Am. J. Pathol. 160:1887-94.
  59. Faustman, E.M., Ponce, R.A., Ou, Y.C., Mendoza, M.A., Lewandowski, T. and Kavanagh. T. (2002) Investigations of methylmercury-induced alterations in neurogenesis. Environ Health Perspect. 110 Suppl 5:859-64
  60. Bea, F., Hudson, F.N.*, Kavanagh, T.J. and Rosenfeld, M.J. (2003). The Induction of Glutathione Synthesis in Macrophages by Oxidized Low Density Lipoproteins is Mediated by Consensus Antioxidant Response Elements. Circ. Res. 92:386-93
  61. Luderer U., Diaz, D.*, Faustmanm, E.M. and Kavanagh, T.J.(2003). Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Mol. Reprod. Dev. 65:254-61.
  62. White, C.C.*, Viernes, H., Krejsa, C.M.*, Botta, D.* and Kavanagh, T.J. (2003). Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity. Anal. Biochem. 318:175-180
  63. Franklin, C.C., Rosenfeld-Franklin, M.E., White, C.C.*, Kavanagh, T.J. and Fausto, N. (2003). TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent posttranslational and caspase-independent transcriptional regulatory mechanisms. FASEB J 17:1535-7
  64. Krzywanski D.M., Dickinson, D.A., Iles, K.E., Wigley, A.F., Franklin, C.C., Liu, R.M., Kavanagh, T.J. and Forman, H.J. (2004). Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Arch Biochem Biophys. 423:116-25.
  65. Kevil, C.G., Pruitt, H., Kavanagh, T.J., Wilkerson, J., Farin, F., Moellering, D., Darley-Usmar, V.M., Bullard, D.C. and Patel, R.P. (2004). Regulation of endothelial glutathione by ICAM-1: implications for inflammation. FASEB J. 18:1321-3.
  66. Botta, D.*, Franklin, C.C., White, C.C.*, Krejsa, C.M.*, Dabrowski, M.J.*, Pierce, R.H., Fausto, N. and Kavanagh, T.J. (2004). Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis. Free Rad. Biol. Med 37:632-42.
  67. Diaz, D.*, Krejsa, C.M.*, White, C.C.*, Charleston, J.S. and Kavanagh, T.J.(2004) Effect of methylmercury on glutamate-cysteine ligase expression in the placenta and yolk sac during mouse development. Reprod Toxicol. 19:117-29.
  68. Takaro, T.K., Engel, L.S., Keifer, M., Bigbee, W.L., Kavanagh, T.J. and Checkoway, H. (2004). Glycophorin A is a potential biomarker for the mutagenic effects of pesticides. Int J Occup Environ Health. 10:256-61.
  69. Tran, P.O., Parker, S.M., Leroy, E., Franklin, C.C., Kavanagh, T.J., Zhang, T., Zhou, H., Vliet, P., Oseid, E., Harmon, J.S. and Robertson R.P. (2004). Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress. J Biol Chem. 279:53988-93.
  70. Bammler, T., Beyer, R.P., Bhattacharya, S., Boorman, G.A., Boyles, A., Bradford, B.U., Bumgarner, R.E., Bushel, P.R., Chaturvedi, K., Choi, D., Cunningham, M.L., Deng, S., Dressman, H.K., Fannin, R.D., Farin, F.M., Freedman, J.H., Fry, R.C., Harper, A., Humble, M.C., Hurban, P., Kavanagh, T.J., Kaufmann, W.K., Kerr, K.F., Jing, L., Lapidus, J.A., Lasarev, M.R., Li, J., Li, Y.J., Lobenhofer, E.K., Lu, X.F., Malek, R.L. Milton, S., Nagalla, S.R., O’Malley,J.P., Palmer, V.S., Pattee, P., Paules, R.S., Perou, C.M., Phillips, K., Qin, L.X., Qiu, L., Quigley, S.D., Rodland, M., Rusyn, I., Samson, L.D., Schwartz, D.A., Shi, Y., Shin, J.L., Sieber, S.O., Slifer, S.L., Speer, M.C., Spencer, P.S., Sproles, D.I., Swenberg, J.A., Suk, W.A., Sullivan, R.C., Tian, R., Tennant, R.W., Todd, S.A., Tucker, C.J., Van Houten, B., Weis, B.K., Xuan, S. and Zarbl, H. (2005). Standardizing Global Gene Expression Analysis Between Laboratories and Across Platforms. Nature Methods 2:351-6.
  71. Ho, H.K., White, C.C.*, Fernandez, C.*, Fausto, N., Kavanagh, T.J., Nelson, S.D. and Bruschi, S.A. (2005). Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity. Toxicol Sci. 86:354-64
  72. Bekris, L.M.*, Shephard, C., Peterson, M., Hoehna, J., Yserloo, B.V., Rutledge, E., Farin, F., Kavanagh, T.J. and Lernmark, A. (2005) Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset. Autoimmunity 38:567-75.
  73. Dabrowski, M.J., Maeda, D., Zebala, J., Lu, W.D., Mahajan, S., Kavanagh, T.J. and Atkins, W.M. (2006) Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin. Arch Biochem Biophys. 449(1-2):94-103.
  74. Bekris L.M.*, Viernes, H.M., Farin, F.M., Maier, L.A., Kavanagh, T.J. and Takaro, T.K. (2006). Chronic beryllium disease and glutathione biosynthesis genes. J Occup Environ Med. 48(6):599-606.
  75. McKone, E.F., Shao, J.*, Frangolias, D.D., Keener, C.L., Shephard, C.A., Farin, F.M., Tonelli, M.R., Pare, P.D., Sandford, A.J., Aitken, M.L. and Kavanagh, T.J. (2006) Variants in the Glutamate-Cysteine-Ligase Gene are Associated with Cystic Fibrosis Lung Disease. Am J Respir Crit Care Med. 174:415-419.
  76. Botta, D.*, Shi, S.*, White, C.C.*, Dabrowski, M.J.*, Keener, C.L., Srinouanprachanh, S.L., Farin, F.M., Ware, C.B., Ladiges, W.C., Pierce, R.H., Fausto, N., Kavanagh, T.J. (2006) Acetaminophen-induced liver injury is attenuated in male glutamate cysteine ligase transgenic mice. J Biol Chem. 281:28865-75.
  77. Giordano, G., White, C.C.*, McConnachie, L.A.*, Fernandez, C.*, Kavanagh, T.J., Costa, L.G. (2006) Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Mol Pharmacol 70:2116-26.
  78. Giordano, G., Afsharinejad, Z., Guizzetti, M., Vitalone, A., Kavanagh, T.J. and Costa, L.G. (2007). Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol 219:181-189.
  79. Bekris, L.M.*, Shephard, C., Janer, M., Graham, J., McNeney, B., Shin, J., Zarghami, M., Griffith, W., Farin, F., Kavanagh, T.J. and Lernmark, A. (2007). Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with Type 1 diabetes age-at-onset and GAD65 autoantibody levels. Exp Clin Endocrinol Diabetes 115(4):221-8.
  80. Beyer RP, Fry RC, Lasarev MR, McConnachie LA*, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Kerr KF, Kosyk O, Lobenhofer EK, Sieber SO, Vliet PA*, Weis BK, Wolfinger R, Woods CG, Freedman JH, Linney E, Kaufmann WK, Kavanagh TJ, Paules RS, Rusyn I, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H; Members of the Toxicogenomics Research Consortium (2007). Multi-Center Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses. Toxicol Sci 99:326-37.
  81. Shi S*, Hudson FN*, Botta D*, McGrath MB*, White CC*, Neff-LaFord HD*, Dabrowski MJ*, Singh NP and Kavanagh TJ (2007). Over Expression of glutamate cysteine ligase increases cellular resistance to H2O2-induced DNA single-strand breaks. Cytometry 71A:686-692.
  82. McConnachie LA*, Mohar I*, Hudson FN*, Ware CB, Ladiges WC, Fernandez C*, Chatterton-Kirchmeier S*, White CC*, Pierce RH and Kavanagh TJ (2007). Glutamate cysteine ligase modifier subunit deficiency and gender as modulators of acetaminophen-induced hepatotoxicity in mice. Toxicol Sci (in press).
  83. Giordano G., White C*, Mohar I*, Kavanagh T and Costa LG (2007). Glutathione levels modulate domoic acid-induced apoptosis in mouse cerebellar granule cells. Toxicol Sci. (in press)

Book Chapters/Reviews/Reports

  1. Kavanagh, T.J., G. Raghu, S.M. Masta and G.M. Martin (1988). Role of metabolic cooperation in modulating sensitivity of V79 cells to superoxide anion. In: Oxy-Radicals in Molecular Biology and Pathology. UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 82. Eds. P. Cerutti, I. Fridovich and J. McCord. Alan R. Liss, Inc., New York, NY, pp.301-312.
  2. Raghu, G. and T.J. Kavanagh (1991). The human lung fibroblast: A multifaceted target and effector cell. In: Interstitial Pulmonary Diseases: Selected Topics. Ed. M.S. Lama and R.Barrios. CRC Press, Boca Raton, FL. pp 1-26.
  3. Rabinovitch, P.S., C.H. June and T.J. Kavanagh (1992). Physiological based measures of cell activation: Calcium, pH and glutathione. Clinical Applications of Flow Cytometry. Ed. T. Shankey, K. Bauer and R. Duque Williams and Wilkins. pp 505-534.
  4. Rabinovitch, P.S., C.H. June and T.J. Kavanagh (1993). Introduction to functional cell assays. Ann. NY Acad. Sci. 166:252-264.
  5. Gallagher, E., T.J. Kavanagh, and D.L. Eaton (1994). Glutathione, oxidized glutathione, and mixed disulphides in biological samples. In: Methods in Toxicology, Vol. 1B: In Vitro Toxicity Indicators, CA Tyson, JM Frazier, eds., Academic Press, Orlando. pp 349-366.
  6. Kavanagh, T.J., A. Grossmann, and D.L. Eaton (1993). Glutathione Biosynthesis as a Biomarker of Toxic Exposures. Proceedings of the Pacific Basin Conference on Hazardous Waste: Health Effects A. Pacific Basin Consortium for Hazardous Waste Research, Honolulu. Paper #93142.
  7. Poot, M., C.H. June, P.S. Rabinovitch and T.J. Kavanagh (1996). Flow cytometric measurement of cellular physiology. In: Weir’s Handbook of Experimental Immunology (Fifth Edition), D. M. Weir, C. Blackwell, L. A. Herzenberg, and L. A. Herzenberg (eds.) pp 53.1-53.11.
  8. White, C.C., C.M. Krejsa, D.L. Eaton and T.J. Kavanagh (1999). HPLC-based Assays for Enzymes of Glutathione Biosynthesis. Curr. Prot. Toxicol. Chapter 6.5
  9. Catlin, M.C., M. Guizetti, R.A. Ponce, L.G. Costa and T.J. Kavanagh (2000). Analytical Cytology: Applications to neurotoxicology. Curr. Prot. Toxicol. Chapter 2.3
  10. Pierce, R.H., Kavanagh, T.J. and Poot, M. (2001). Cell Staining: Fluorescence imaging of mitochondrial structure and function. In: Nature Encyclopedia of Life Sciences. London: Nature Publishing Group. http://www.els.net/[doi:10.1038/npg.els.0002632]
  11. Poot. M., Pierce, R.H. and Kavanagh, T.J. (2002). Flow cytometric and fluorometric methods of quantifying and characterizing apoptic cell death. In: Apoptosis Methods in Pharmacology and Toxicology. Approaches to Measurement and Quantification. M.A. Davis (ed.) Humana Press. Baltimore, MD.
  12. Bekris, L.M.*, Kavanagh, T.J. and Lernmark, A. (2006) Targeting type 1 diabetes before and at the clinical onset of disease. Endocr Metab Immune Disord Drug Targets. 6(1):103-24.

Technical Reports

  1. Aulerich, R.J., T.H. Coleman, D. Polin, R.K. Ringer, K.S. Howell, R.E. Jones and T.J. Kavanagh (1979). Toxicology study of diisopropyl methylphosphonate and dicyclo- pentadiene in mallard ducks, bob-white quail and mink. U.S. Army Research and Development Command, Fort Detrick, Frederick, MD, 343 pp.

Published Abstracts

  1. Kavanagh, T.J. and C.A. Simon (1980). Hazard assessment technique for determining water quality based effluent limits. Poster presented at the 2nd Annual Meeting, Society for Environmental Toxicology and Chemistry, Arlington, VA.
  2. Kavanagh, T.J. (1980). Michigan's Critical Materials Register Program. Platform presentation at 2nd Annual Meeting, Society for Environmental Toxicology and Chemistry, Arlington, VA.
  3. Kavanagh, T.J., P.S. Rabinovitch and G.M. Martin (1986). Intercellular sharing of glutathione via metabolic cooperation quantitated by flow cytometry. J. Cell Biol. 103(5, pt. 2):474a.
  4. Kavanagh, T.J., G.M. Martin and P.S. Rabinovitch (1987). Cell-cell communication quantitated by scrape-loading and flow cytometry. Cytometry Suppl. 1:353a.
  5. Kavanagh, T.J., G. Raghu, S.M. Masta and G.M. Martin (1988). Role of metabolic cooperation in modulating sensitivity of V79 cells to superoxide anion. J. Cell. Biochem. Suppl. 12A:B312a.
  6. Kavanagh, T.J., G. M. Martin and P.S. Rabinovitch (1988). Enhancement of glutathione content in glutathione synthetase deficient fibroblasts through intercellular communication with normal fibroblasts. Cytometry Suppl. 2:329a.
  7. Kavanagh, T.J., A. Grossmann, G.M. Martin and P.S. Rabinovitch (1988). Effect of 2-mercaptoethanol and glutathione content on lymphocyte proliferation. Cytometry Suppl. 2:423a.
  8. Kavanagh, T.J., C.C. Chang, J.E. Trosko, A. Grossmann, G. Raghu, S.E. Masta, P.S. Rabinovitch and G.M. Martin (1988). Metabolic cooperation defective Chinese hamster V79 cells have an abnormality in glutathione homeostasis. Presented at "Toxicological Implications of Altered Gap Junctional Intercellular Communication", Sept. 28-30, E. Lansing, MI.
  9. Kott, J.N., L.E. Westrum, E.E. Ogburn, T.J. Kavanagh, and G.M. Martin (1989). Retrovirally-inserted b-gal-actosidase genes as markers for donor cells in neural grafting. Proc. Soc. Neurosci. 15:1368a.
  10. Holman, R.G., R.V. Maier, G. Raghu, and T.J. Kavanagh (1989). Role of ATP and glutathione in oxidant induced morphologic changes of pulmonary microvascular endothelial cell injury. Amer. Rev. Resp. Dis. 139(4 pt. 2):A421.
  11. Raghu, G., T.J. Kavanagh, S. Masta, and G.M. Martin. (1989). Differential susceptibility to g-irradiation in isogenic pairs of normal human diploid fibroblasts strains. Amer. Rev. Resp. Dis. 139(4 pt. 2):A494.
  12. Kavanagh, T.J., G. Raghu, R.V. Maier and R.G. Holman (1989). Rabbit pulmonary endothelial cells display heterogeneity in glutathione content when exposed to oxidant stress. Platform presentation given to Pacific Northwest Association of Toxicologists, Vancouver, BC, September 15-16.
  13. Kavanagh, T.J., G. Raghu, P.S. Rabinovitch and G. M. Martin (1989). Paraquat resistant chinese hamster ovary cells show resistance to glutathione depletion by paraquat but not by hydrogen peroxide. Poster presented at Pacific Northwest Association of Toxicologists, Vancouver, BC, September 15-16.
  14. Grossmann, A., T.J. Kavanagh, J.C. Jinneman and P.S. Rabinovitch (1989). The growth of g-irradiated CD4+ human lymphocytes is dependent on glutathione content and not donor age. Poster presented at Pacific Northwest Association of Toxicologists, Vancouver, BC, September 15-16.
  15. Kavanagh, T.J., G. Raghu, P.S. Rabinovitch and G. M. Martin (1990). Paraquat resistant chinese hamster ovary cells show resistance to glutathione depletion by paraquat but not by hydrogen peroxide. Toxicologist 10(1):470.
  16. Kavanagh, T.J., A. Grossmann, J.C. Jinneman and P.S. Rabinovitch (1990). Effect of glutathione on cell activation and transmembrane signal transduction. Cytometry Suppl. 4:17a
  17. Kavanagh, T.J., A. Grossmann, J.C. Jinneman and P.S. Rabinovitch (1990). Evaluation of Fluo-3 and Indo-1 as calcium probes in human CD4+ lymphocytes. Cytometry Suppl. 4:69a.
  18. Grossmann, A., T.J. Kavanagh, J.C. Jinneman and P.S. Rabinovitch (1990). The growth of g-irradiated CD4+ human lymphocytes is dependent on glutathione content and not donor age. Cytometry Suppl. 4:595a.
  19. Poot, M., T.J. Kavanagh, H.C. Kang, R.P. Haugland, P.S. Rabinovitch, and H. Hoehn (1990). Glutathione content of cells in different cell cycle compartments analysed with Hoechst 33342 and 5(6) methylfluorescein-diacetate flow cytometry. Cytometry Suppl. 4:66a.
  20. Holman, R.G., G. Raghu, R.V. Maier and T.J. Kavanagh (1990). Pretreatment with 3-aminobenzamide and rotenone preserves pulmonary endothelial cell glutathione content after oxidant injury. Amer. Rev. Resp. Dis. 141:534a.
  21. Holman, R.G., R.V. Maier and T.J. Kavanagh (1990). Oxidant injured endothelial cells display a confluence dependent bimodal distribution in glutathione. Thirteenth Annual Conference on Shock, Durango CO.
  22. Kavanagh, T.J., A. Grossmann, J.C. Jinneman and P.S. Rabinovitch (1991). Glutathione depletion inhibits transmembrane signal transduction in human CD4+ and CD8+ lymphocytes. Toxicologist 11(1):117a.
  23. Channel, S.R., D.L. Eaton and T.J. Kavanagh (1991). Regulation of intracellular glutathione in a rat, diploid hepatic epithelial cell line. Toxicologist 11(1):127a.
  24. Masta, S.E., G. Raghu, G.M. Martin, and T.J. Kavanagh (1991). Intracellular glutathione content correlates with the extent of gap junctional intercellular communication in rat-1 fibroblasts variants with abnormal glutathione content. Toxicologist 11(1):1058a.
  25. Siminski, J., T.J. Kavanagh, G. Raghu (1991). Subpopulations of human lung fibroblasts based on thymocyte-1 surface antigen expression. Amer. Rev. Resp. Dis. 143:518a
  26. Siminski, J., T.J. Kavanagh, R.G. Holman, D.L. Luchtel and G. Raghu (1991). Recombinant tumor necrosis factor (r-TNF) is essential for pulmonary changes induced by silica in long term isolated lung cultures. Amer. Rev. Resp. Dis. 143:726a
  27. Holman, R.G., R.V. Maier, G. Raghu and T.J. Kavanagh (1991). Oxidant injury depletes pulmonary endothelial cell total RNA. Amer. Rev. Resp. Dis. 143:735a
  28. Montgomery, K., T. Pohlman, P. Tarr, T. Kavanagh, and G. Raghu (1991). Transcriptional control of activation genes in human endothelial cells and lung fibroblasts stimulated with tumor necrosis factor (TNF), interleukin-1 (IL-1) or lipopolysaccharide (LPS; endotoxin). Amer. Rev. Resp. Dis. 143:511a
  29. Wade, M.H. and T.J. Kavanagh (1991). Glutathione and glutathione-s-transferase measurements in individual adherent 3T3 cells. Cytometry Suppl. 5:516a
  30. Kavanagh, T.J., S.E. Masta, D.L. Eaton, G.M. Martin, P.S. Rabinovitch and G. Raghu. Isolation by FACS of Rat-1 fibroblast variants with altered glutathione content. Cytometry Suppl. 5:522a
  31. Kavanagh, T.J., J.K. Walton, G. Raghu, P.S. Rabinovitch and R.G. Holman (1991). Heterogeneity in glutathione and NAD(P)H revealed by flow cytometry in cultured rabbit endothelial cells after oxidant injury. Cytometry Suppl. 5:521a
  32. Grossmann, A., T.J. Kavanagh, J.C. Jinneman, P.S. Rabinovitch (1991). The influence of glutathione on proliferation and aging in CD4+ and CD8+ lymphocytes. Cytometry Suppl. 5:62a
  33. Grossmann, A., T.J. Kavanagh, J.A. Ledbetter, P.S. Rabinovitch (1991). Influence of glutathione and redox status on transmembrane signalling. Cytometry Suppl. 5:271a
  34. Kavanagh, T.J., J. Walton, M.T. Orsborn, G. Raghu and R.G. Holman (1992). Pretreatment of rabbit pulmonary endothelial cells with 3-aminobenzamide preserves NAD(P)H and glutathione during oxidant injury. Toxicologist 12:175a
  35. Ogburn, C.E., M.T. Orsborn, C.C. White, D.L. Eaton, G.M. Martin and T.J. Kavanagh (1992). Mouse teratocarcinoma cells selected for oxygen resistance have increased glutathione content. Toxicologist 12:191a
  36. Holman R.G., R.V. Maier, J. Walton and T.J. Kavanagh (1992). Oxidant-induced injury of pulmonary vascular endothelial cells activates xanthine oxidase. Amer. Rev. Resp. Dis. 145(4):A577
  37. Lurton, J., D. Bowen-Pope, T. Kavanagh, G. Raghu (1992). Differential mitogenic effect of PDGF isoforms on fibroblasts cultured from normal and fibrotic human lungs. Amer. Rev. Resp. Dis. 145(4):A842
  38. Orsborn, M.T., M.T. Reilly, A.J. Potter and T.J. Kavanagh (1992). Measurement of glutathione content in the mouse lung using morphometric analysis and laser confocal microscopy. 31st Hanford Symp. Health Env. Richland, WA.
  39. Sidhu, J.S., T.J. Kavanagh, M.T. Reilly, M.T. Orsborn and Omiecinski, C.J. (1993). Determination of Phase I and Phase II biotransformation activity in single cells using noninvasive laser cytometry. Toxicologist 13:166a.
  40. Davila, D.R., J.L. Born, T.J. Kavanagh, A. Grossmann, P.S. Rabinovitch, D.L. Eaton and S.W. Burchiel (1993). Use of multiparameter flow cytometry to estimate intracellular levels of reduced glutathione (GSH) in lymphoid cells. Toxicologist 13:268a.
  41. Potter, A.J., A. Grossmann, P.S. Rabinovitch, D.L. Eaton and T.J. Kavanagh (1993). The effect of in vivo exposure to phorone and buthionione sulfoximine on glutathione content, calcium mobilization and DNA synthesis in mouse splenocytes. Toxicologist 13:271a.
  42. Beck, N., L.C. Altman, J.Q. Koenig, D.L. Luchtel, M.T. Orsborn, L.G. Costa, M.T. Reilly and T.J. Kavanagh (1993). Development of a quantitative morphometric approach to examine the effects of ozone on intercellular adhesion molecule-1 (ICAM-1) on human nasal epithelial cells (HNE). Toxicologist 13:1145a
  43. Ponce, R.A., N.K. Mottet, T.J. Kavanagh and E.M. Faustman (1993). Cell cycle analysis of primary rat CNS cells following exposure to methylmercury. Toxicologist 13:1148a.
  44. Omiecinski, C.J., M.T. Reilly, T.J. Kavanagh and J.S Sidhu, (1993). Dexamethasone mediated modulation of phenobarbital-inducible CYP450 gene expression in primary rat hepatocytes. Toxicologist 13:1347a.
  45. Kavanagh, T.J., L.L. Reid and Y.C.Ou (1993). Improved method for evaluating gap-junctional intercellular communication by scrape-loading/flow cytometry using single excitation source instruments. Toxicologist 13:1375a.
  46. Ou, Y.C., M.T. Orsborn, M.T. Reilly and T.J. Kavanagh, (1993). Evaluation of gap-juncitonal intercellular communication in rat-1 fibroblast glutathione variants using fluorescence recovery after photobleaching. Toxicologist 13: 1376a
  47. Heinonen, J., J.S Sidhu, M.T. Reilly, F.M. Farin, M.T. Orsborn, C.J. Omiecinski, D.L. Eaton and T.J. Kavanagh (1993). Assessment of cytochrome P450 activity in intact cells of rat liver slices using resorufin substrates and fluorescence confocal laser cytometry. Toxicologist 13:1708a.
  48. Orsborn, M.T., M.T. Reilly and T.J. Kavanagh (1993). Imaging of the pleural and subpleural areas in viable mouse lung with fluorescence confocal laser cytometry. Cytometry Suppl 6:195a.
  49. Reilly, M.T., C.E. Ogburn, M.T. Orsborn, G.M. Martin and T.J. Kavanagh (1993). Carbachol induced calcium transients in differentiated normal and oxygen resistant P19 mouse teratocarcinoma cells. Cytometry Suppl 6:56a.
  50. Poot, M., T.J. Kavanagh, P.S. Rabinivitch and H. Hoehn (1993). ATP-dependent secretion of MCB-glutathione adducts by rat-1 fibroblasts. Cytometry Suppl 6:35a.
  51. Ou, Y.C., M.T. Orsborn, M.T. Reilly and T.J. Kavanagh (1993). Improved method for measuring gap-junctional intercellular communication by fluorescence redistribution after photobleaching. Cytometry Suppl 6:218a.
  52. Orsborn, M., T.J. Kavanagh, R. Hert, J. Siminski and Raghu, G. (1993). The application of digital image analysis and quantitative morphometrics to examine histological changes associated with experimental pulmonary fibrosis. Amer. Rev. Resp Dis. 147(4):A591.
  53. Hill, J.P., L.L. Reid and T.J. Kavanagh (1994). Cloning and partial characterization of the mouse g-glutamyl-cysteine synthetase gene. Toxicologist 14:641a.
  54. Grossmann, A., T.J. Kavanagh and J.S. Woods (1994). The effects in vivo lead exposure on rat T-lymphocyte function. Toxicologist 14:949a
  55. Ponce, R.A., M.T. Reilly, N.K. Mottet, T.J. Kavanagh and E.M. Faustman, (1994). The effects of methylmercury on intracellular calcium in primary rat CNS cells. Toxicologist 14:1187a
  56. Luchtel, D.L., S.L. Stuebbe, T.J. Kavanagh, L.C. Altman and J.O. Koenig (1994). Flow cytometric measurement of glutathione content in respiratory epithelial cells exposed in vitro. Toxicologist 14:1226a.
  57. Krejsa, C.M. J.A. Ledbetter and T.J. Kavanagh (1995). Oxidant induced changes in red autofluorescence in lymphocytes and lymphoblastoid cell lines correlates with decreased glutathione. Toxicologist 15:158a.
  58. Reid, L.L. and T.J. Kavanagh (1995). Cloning and sequencing of the mouse cDNAs encoding the light and heavy subunits of g-glutamylcysteine synthetase. Toxicologist 15:1613a.
  59. Thompson, S.A., A. Grossmann, C.C. White, D.L. Eaton, S.G. Gilbert and T.J. Kavanagh (1995). Strain specific effects of sub-chronic, low level methylmercury exposure on GSH levels in mice. Toxicologist 15:1616a
  60. Krejsa, C.M., J.M. Esselstyn, A.F. Wahl, T.J. Kavanagh, J.A. Ledbetter and G.L. Schieven (1995). The role of oxidative stress in the action of a peroxyvanadium phosphotyrosine phosphatase inhibitor. Pacific Northwest Association of Toxicologists Annual Meeting, Moscow, ID.
  61. Hudson, F.N., M. Poot. and T.J. Kavanagh (1996). Effect of probenicid, vanadate and verapamil on extrusion of the glutathione conjugate of monochlorobimane from rat-1 fibroblasts. Toxicologist 30:1453a
  62. Reid, L.R., S.A. Thompson, C.C. White and T.J. Kavanagh (1996). Transfection and expression of the mouse cDNA encoding the catalytic and regulatory subunits of mouse glutamylcytsteinyl ligase in mammalian cells. Toxicologist 30:1460a.
  63. Ou, Y.C., M.R. Seeley, S.A. Thompson, T.J. Kavanagh and E.M. Faustman (1996). Chemical-induced gene expresssion: Study of methylmercury in differentiating neuronal cells. Toxicologist 30:851a
  64. Krejsa, C.M., S.G. Nadler, J.M. Esselstyn, T.J. Kavanagh, J.A. Ledbetter and G.L. Schieven (1996). The differential role of oxidative stress in the activation of protein tyrosine kinases, MAP kinase, and NFkB by vanadium phosphotyrosine phosphatase inhibitors. FASEB J. 10(6): P10.
  65. Lu, Y., L. R. Reid, D. Neil and T. J. Kavanagh (1996). Cloning and sequence determination of the 5’ promoter region of the mouse glutamylcysteine ligase heavy subunit gene. Pacific Northwest Association of Toxicologists Annual Meeting, Troutdale, OR.
  66. Diaz, D., S.A. Thompson, W.G. Kirlin, D.P. Jones and T.J. Kavanagh (1996). Expression of GST and GCS mRNAs in HT29 cells after treatment with benzylisothio-cyanate and sodium butyrate. Pacific Northwest Association of Toxicologists Annual Meeting, Troutdale, OR
  67. Kirchner, S.C., T.A. Lewandowski, T.J. Kavanagh, R.M. Finnell, T.K. Takaro, J.S. Woods, and E.M. Faustman (1996). Analysis of gene expression in human urothelial cells as biomarkers of exposure. Pacific Northwest Association of Toxicologists Annual Meeting, Troutdale, OR
  68. Ou, Y.C., S.A. Thompson, T.J. Kavanagh and E.M. Faustman (1996). Activation of cell cycle regulatory gene expression in primary embyonic cells following methylmercury exposure in vitro. Pacific Northwest Association of Toxicologists Annual Meeting, Troutdale, OR
  69. Kirchner S.C, T.A. Lewandowski, T.J. Kavanagh, T. Takaro, J.S. Woods, and E.M. Faustman (1997). Utility of human urothelial cells as molecular biomarkers of gene expression. Toxicologist 36:31a
  70. Diaz, D., S. Thompson, W.G. Kirlin, D.P. Jones and T.J. Kavanagh (1997). Expression of GST and GCL mRNA in HT29 cells after treatment with BIT and NaB. Toxicologist 36:401a.
  71. Thompson, S.A., C.C. White, C.M. Krejsa, S.C. Kirchner, Y.C. Ou, E.M. Faustman and T.J. Kavanagh (1997). Modulation of glutathione associated with developmental methylmercury exposure in mice. Toxicologist 36:521a
  72. Quigley, S.D., S.A. Thompson, S.C. Kirchner, E.M. Faustman and T.J. Kavanagh (1997). RNA amplification and reverse northern analysis to measure gene expression in MeHg exposed mice. Toxicologist 36:622a.
  73. Ou, Y.C., J.L. Schroeder, C.C. White, T.J. Kavanagh and E.M. Faustman (1997). Modulation of MeHg-induced toxicity and gene expression in rodent embryonic cells by n-acetylcysteine in vitro. Toxicologist 36:1493a.
  74. Broudy, V.C., N.L. Lin, H.J. Bühring, N. Komatsu and T.J. Kavanagh (1997). Analysis of c-Kit receptor dimerization by fluorescence resonance energy transfer. Amer. Soc. Hematol. Annual Meeting, San Diego CA.
  75. Krejsa, C.M., C.C. White, L. Grossmaire, S. Plevy, S. Targon, T. Kavanagh, G. Schieven and J. Ledbetter (1997). Role of glutathione in lymphocyte redox balance and functional development. Pacific Northwest Association of Toxicologists Annual Meeting, Ocean Shores, WA. Abstract #5.
  76. Shao, J., D. Neil and T.J. Kavanagh (1997). Verification of mouse glutamate-cysteine ligase cDNA sequence using thermal RACE. Pacific Northwest Association of Toxicologists Annual Meeting, Ocean Shores, WA Abstract #28.
  77. Reese, A.W., G.M. Martin, T.J. Kavanagh, J. Corral and J.S. Woods (1998). ESR measurement of chemical-induced free radical formation in intact cells: Effects of over-expression of endogenous antioxidants. Toxicologist 42(1-S) 738a.
  78. Quigley, S.D., S.A. Thompson, S.C. Kirchner, E.M. Faustman and T.J. Kavanagh (1998). RNA amplification and reverse northern analysis to measure gene expression in MeHg exposed mice. Toxicologist 42(1-S) 964a.
  79. Krejsa, C., C. White, L Grossmaire, S. Plevy, S. Targon, T Kavanagh, G. Schieven and J. Ledbetter (1998). Role of glutathione in lymphocyte redox balance and functional development. Toxicologist 42(1-S) 1337a.
  80. Hudson, F.N. and T.J. Kavanagh (1998). Characterization of the 5’ proximal promoter region of the mouse gamma-glutamate cysteine ligase regulatory subunit gene. Toxicologist 42(1-S) 1355a.
  81. Lu, Y., L.R. Reid, D. Neil and T.J. Kavanagh (1998). Cloning and sequence determination of the 5’ promoter region of the mouse gamma-glutamate cysteine ligase catalytic subunit gene. Toxicologist 42(1-S) 1356a.
  82. Kirchner, S.C., K.A. Hunt, T.J. Kavanagh, T.A. Lewandowski, S.W. Hong, C.H. Muller, M. Gold and E.M. Faustman (1998). Analysis of gene expression changes in uroepithelial cells as biomarkers of heat stress. Toxicologist. 42(1-S) 1533a.
  83. Lu, S., E.M. Faustman and T.J. Kavanagh (1998). Effects of methylmercury on mitochondrial transmembrane potential in Hepa-1 cells overexpressing glutamate-cysteine ligase. . Pacific Northwest Association of Toxicologists Annual Meeting, Leavenworth, WA. Abstract #15.
  84. Shi, S., Lu, S., D. Botta and T.J. Kavanagh (1999). Growth rates and effects of methyl mercury on survival rate and mitochondrial transmembrane potential in hepa-1 cells overexpressing glutamate-cysteine ligase. Toxicol Sci. 48(1S):1851.
  85. Botta, D., C.C. White, C.M. Krejsa, R.H. Pierce, N.Fausto, D.L. Eaton and T.J. Kavanagh (1999). Effect of overexpression of glutamate-cysteine ligase on TNF and Actinomycin D-induced apoptosis in Hepa-1 mouse liver cells. Toxicol Sci. 48(1S):1852a.
  86. Yager, J.W., Kirchner, S.C., Kavanagh, T.J. and Faustman, E.M. (1999). Gene expression analysis in urothelial cells from an arsenate exposed worker population. Toxicol Sci. 48(1S):1298a
  87. Jabbour, A.J., Hill, J.A., Ponce, R.A., Ertell, K.B., Kavanagh, T.J., Newman, L.S., Takaro, T.K., and Faustman, E.M. (1999). A flow cytometric method to screen for beryllium sensitization. Toxicol Sci. 48(1S):1488a.
  88. Luderer, U., Kavanagh, T.J., White, C.C. and Faustman, E.M. (1999). Gamma-glutamatecysteine ligase (Glcl) activity and expression during the estrous cycle in the rat ovary. Toxicol Sci. 48(1S):1813a.
  89. Diaz-Lopez, D. and Kavanagh, T.J. (1999). Expression of glutamate-cysteine ligase catalytic and regulatory subunit mRNAs in mouse embryos by in-situ hybridization. Pacific Northwest Association of Toxicologists Annual Meeting, Hood River, OR. Abstract #13.
  90. Shao, J., Keener, C.L., Lurton, J., Farin, F.M., Raghu, G. and Kavanagh, T.J. (1999). Genetic control of susceptibility to idiopathic lung fibrosis. Pacific Northwest Association of Toxicologists Annual Meeting, Hood River, OR. Abstract #23.
  91. White, C.C., Viernes, H.A., Krejsa, C.M., Botta D. and Kavanagh, T.J. (1999). Fluorescence-based assay for glutamate-cysteine ligase activity in microtiter plates. Pacific Northwest Association of Toxicologists Annual Meeting, Hood River, OR. Abstract #31.
  92. Shao,J. Keener, C.L., Lurton, J., Farin, F.M., Raghu, G. and Kavanagh, T.J. (2000). Genetic polymorphisms in two glutathione associated genes and susceptibility to idiopathic pulmonary fibrosis. Toxicol Sci. 54(1S):120a.
  93. Diaz-Lopez, D., White, C.C., Krejsa, C.M., Keener, C.L., Farin, F.M. and Kavanagh, T.J. (2000). Tissue specific changes in glutathione and the expression of the catalytic and regulatory subunits of glutamate-cysteine ligase in mice exposed to methylmercury: A time course study. Toxicol Sci. 54(1S):122a.
  94. Shi, S., Botta, D., White, C.C. and Kavanagh, T.J. (2000). Effect of increasing GSH synthesis on resistance of hepa-1 cells to DNA breaks caused by H2O2. Toxicol Sci. 54(1S):123a.
  95. White, C.C., Viernes, H.A., Krejsa, C.M., Neil, D. and Kavanagh, T.J. (2000). Fluorescence-based assay for glutamate-cysteine ligase activity in microtiter plates. Toxicol Sci. 54(1S):140a.
  96. Keener, C.L., Quigley, S.D., Diaz-Lopez, D., Farin, F.M. and Kavanagh, T.J. (2000). Quantiation of mouse GLCL-R and GLCL-C mRNA and other glutathione related enzymes using fluoregenic 5’ nuclease assays. Toxicol Sci. 54(1S):141a.
  97. Lu, S., Kavanagh, T.J. and Faustman E.M. (2000). Methylmercury’s effects on mitochondrial DNA in developing rodent midbrain. Toxicol Sci. 54(1S):162a.
  98. Botta, D., White, C.C., Krejsa, C.M. and Kavanagh T.J. (2000). Enhanced glutathione biosynthesis retards apoptosis in spite of caspase-3 activation in hepa-1 cells overexpressing glutamate-cystiene ligase. Toxicol Sci. 54(1S):532a.
  99. Krejsa, C.M., Franklin, C.C., Pierce, R.H., White, C.C., Fausto, N. and Kavanagh T.J. (2000). Glutamate cysteine ligase catalytic subunit is cleaved during apoptotic cell death. Toxicol Sci. 54(1S):619a.
  100. Garry, M.R., Kavanagh, T.J. and Faustman E.M. (2000). Phosphatidylcholine hydroperoxide decreases mitochondrial membrane potential and oxidizes cardiolipin. Toxicol Sci. 54(1S):767a.
  101. Pierce, R.H., Poot, M., Kavanagh, T.J. and Fausto N. (2000). Ratiometric analysis of nonylacridine orange (NAO) fluorescence is a sensitive index of oxidative loss of mitochondrial cardiolipin. Toxicol Sci. 54(1S):949a
  102. Luderer, U., Diaz, D., Kavanagh, T.J. and Faustman E.M. (2000). Localization of glutamate cysteine ligase (GLCL) subunit mRNAs with the rat ovary. Toxicol Sci. 54(1S):1206a.
  103. Kavanagh, T.J. (2000). The effects of overexpression of glutamate-cystiene ligase on cell survival, cell growth and apoptosis. Toxicol Sci. 54(1S):1403a.
  104. Hudson, F.N., Shi, S., Botta D., Rabinovitch P.S. and Kavanagh T.J. (2000). Flow cytometric analysis of DNA strand breaks by DNA unwinding in cells overexpressing glutamate-cysteine ligase. Free Rad. Biol. Med. 29(1S):359a.
  105. Diaz-Lopez, D., White, C.C., Keener, K.L., Farin, F.M., Charleston, J. and Kavanagh, T.J. (2000). Effects of low dose methylmercury exposure on expression of glutamate-L-cysteine ligase subunits during mouse development. Superfund Research Program: Oxidative Processes: Stress to Remediation. Carolina Inn, Chapel Hill, N.C.
  106. Kavanagh, T.J. (2000). Changes in glutamate-L-cysteine ligase expression in response to toxicant exposure: Role in cytoprotection and apoptosis. Superfund Research Program: Oxidative Processes: Stress to Remediation. Carolina Inn, Chapel Hill, N.C.
  107. Shi, S, Ogburn, C.E., Schriner, S.E., Martin, G.M. and Kavanagh, T.J. (2001). Levels of GPX, GRX and G6PDH in catalase transgenic mice of different ages. Toxicol. Sci. 60(1S): 222a
  108. Bekris L.M., Jabbour, A.J., Takaro T.K., Kavanagh, T.J. and Faustman E.M. (2001). PHA stimulation induced elevated glutamate-cysteine ligase levels in human peripheral blood lymphocytes: improved flow cytometry based method for evaluating immune and antioxidant relationships. Toxicol. Sci. 60(1S): 788a.
  109. Shao, J., Keener, CL, Farin, FM, Tonelli, M.R., Aitken, M.L. and Kavanagh, T.J. (2001). Characterization of GLCL gene polymorphisms in cystic fibrosis. Toxicol. Sci. 60(1S): 789a.
  110. Botta, D., White, C.C., Shi, S. Ware, C.B., Ladiges, W.C., Fausto, N., Tsai, S.Y., O’Malley, B.W. and Kavanagh, T.J. (2001). Development of a transgenic mouse model for inducible expression of glutamate-cysteine ligase. Toxicol. Sci. 60(1S): 790a.
  111. White, C.C. and Kavanagh, T.J. (2001). A sensitive and specific assay for glutathione in microtiter plates using 2,3-naphthalenedicarboxaldehyde. Toxicol. Sci. 60(1S): 801a.
  112. Diaz-Lopez, D., White C.C., Keener, C.L., Farin F.M. and Kavanagh, T.J. (2001). Tissue dependent differential expression of glutamate-cysteine ligase subunits during mouse development. Toxicol. Sci. 60(1S): 994a.
  113. Pierce, R.H., Krejsa, C.M., Diaz-Lopez, D., Campbell, J.S., Fausto, N. and Kavanagh, T.J. (2001). Upregulation of glutamate-cysteine ligase in perinecrotic hepatocytes in mice exposed to carbon tetrachloride. Toxicol. Sci. 60(1S):996a.
  114. Lu, S., Kavanagh, T.J. and Faustman, E.M. (2001). Effects of methylmercury on mitochondria in the developing brain. Toxicol. Sci. 60(1S): 1697a.
  115. Jabbour, A.J., Ponce, R.A., Rosato, M.T. Kavanagh, T.J., Newman, L.S., Takaro, T.K. and Faustman, E.M. (2001). A flow cytometric assay for beryllium sensitization: screening and mechanistic applications. Toxicol. Sci. 60(1S): 1908a.
  116. Botta, D., White, C.C., Shi, S., Dabrowski, M.J., Keener, C.L., Farin, F.M., Bammler, T.K., Ware, C.B., Ladige, W.C., Fausto, N., Tsai, S.Y., O’Malley, B.W. and Kavanagh, T.J. (2001). Development of a transgenic mouse model for inducible expression of glutamate cysteine ligase. Sixth International Meeting of the International Society for the Study of Xenobiotics, Munich, Germany.
  117. Franklin C.C. Rosenfeld, M.E., White, C.C., Kavanagh, T.J. and Fausto, N. Suppression of glutathione biosynthesis during TGF-beta-1-induced apoptosis. Free Rad. Biol. Med. 31(1S):S101a.
  118. Shi, S., Botta, D., White, C., Dabrowski, M., Srinouanprachanh, S., Farin, F., Pierce, R., Ware, C., Ladige, W., Fausto, N., Tsai, S., O’Malley, B. and Kavanagh, T. (2002). Inducible expression of glutamate cysteine ligase affects carbon tetrachloride-induced liver injury in transgenic mice. Toxicol. Sci. 66(1S):689a.
  119. Hudson, F., Bea, F., Rosenfeld, M. and Kavanagh, T. (2002). Regulation of the mouse glutamate cysteine ligase modifier subunit gene via the ARE and NRF/AP1 binding sites. Toxicol. Sci. 66(1S):690a.
  120. Bekris, L., Jabbour, A., Dabrowski, M., Takaro, T., Kavanagh, T. and Faustman, E. (2002). Glutamate-cysteine ligase levels in human peripheral blood lymphocyte subsets. Toxicol. Sci. 66(1S):691a. Garry, M, Kavanagh, T.J., Faustman, E.M., Sidhu, J. and Deeb, S. (2002) Differential susceptibility to oxidative stress in mouse lung fibroblasts heterozygous for a GPx4 null allele. Free Rad Biol Med 33:310a
  121. Krzywanski, D.M. Dickinson, D.A., Liu, R.-M., Franklin, C.C., Kavanagh, T.J. and Forman, H.J. (2002). Quantitating glutamate-cysteine ligase (GCL) subunit ratio in vivo. Free Rad Biol Med 33:148a
  122. Kevil, C., Moellering, D., Kavanagh, T. and Patel, R. (2002) ICAM-1 Modulates GCLC expression and GSH localization within endothelial cells. Free Rad Biol Med 33: 120a
  123. Bekris, L.*, Shephard, C., Zarghami, M., Farin, F., Griffith, W., Kavanagh, T. and Lernmark, A. (2002), Glutamate cysteine ligase catalytic subunit trinucleotide repeat polymorphism and type 1 diabetes. Free Rad Biol Med 33: 57a.
  124. Barrus, H.M.*, Srinouanprachanh, S., Hooper, M.J., McMurray, S.T., Cobb, G.P. and Kavanagh, T.J. (2002). Metallothionien and glutamylcysteine ligase expression in metal-exposed small mammals. 23rd Annual Meeting of the Society of Environmental Toxicology and Chemistry, Salt Lake City, UT.
  125. Garry, M.R., Sidhu, J.S., Kavanagh, T.J. and Faustman, E.M. (2003). Differential modulation of stress and ubiquitination signaling pathways by cadmium, H2O2, and serum withdrawal in cultured mouse fibroblasts. Toxicol. Sci. 72(S1):311a
  126. Shi, S.*, Hendsch M.B., Ogburn, C.E., Rabinovitch, P.S., Martin, G.M. and Kavanagh T. (2003). Female mice transgenic for mitochondrial directed catalase have altered gluthine rdox cycle enzyme activities coincident with tissue specific catalase expression. Toxicol. Sci. 72(S1):394a
  127. Bekris, L.M.*, Shephard, C., Zarghami, M. Farin, F, Griffith, W.C., Kavanagh, T. and Lernmark, A. (2003). Glutamate cysteine ligase catalytic subunit trinucleotide repeat polymorphism and type I diabetes. Toxicol. Sci. 72(S1):480a
  128. Shao, J.*, McKone, E.F., Keener, C.L., Shephard, C.A., Farin, F.M., Aitken, M.L. and Kavanagh, T.J. (2003). The modification of cystic fibrosis lung disease by a polymorphism in a glutamate cysteine ligase gene. Toxicol. Sci. 72(S1):487a
  129. Kavanagh, T.J., Shi, S.*, Botta, D.*, White, C., Dabrowski, M., Shepard, C., Quigley, S., Farin, F., Beyer, R., Pierce, R., Franklin, C., Zarbl, H. and Bammler, T. (2003). Using toxicogenomic analysis to assess the protective effects of enhanced glutathione synthesis in glutamate cysteine ligase transgenic mice. Toxicol. Sci. 72(S1):805a.
  130. Barrus, H.*, Srinouanprachanh, S., Hooper, M.J., McMurry, S.T., Cobb, G.P., and Kavanagh, T.J. (2003). Metallothionein and glutamate cysteine ligase gene expression in metal exposed small mammals. Toxicol. Sci. 72(S1):927a.
  131. Shi, S*, Botta, D*, White, C*, Dabrowski, M*, Shepard, C, Quigley, S, Farin, F, Beyer, R, Pierce, R, Franklin, C, Zarbl, H and Bammler, T and Kavanagh, T (2003). Effects of Enhanced Glutathione Synthesis on Carbon Tetracholoride-induced Differential Gene Expression in Glutamate-Cysteine Ligase Transgenic Mice Livers. Free Rad. Biol. Med. 35(S1):227a
  132. Thompson, JA, Kavanagh, TJ, White, CC*, Fausto, N and Franklin, CC (2003). Distinct molecular mechanisms mediate AS3+-induced glutamate cysteine ligase subunit gene expression in murine hepatocytes. Free Rad. Biol. Med. 35(S1):189a
  133. Krzywanski, DM, Dickinson, DA, Wigley, AF, Franklin, CC, Kavanagh, TJ and Forman, HJ (2003). Oxidative stress elevates the molar ratio of glutamate cysteine ligase (GCL) catalytic to modulatory subunits. Free Rad. Biol. Med. 35(S1):204a
  134. LeVire, H.*, Srinouanprachanh, S., Hooper, M., McMurry, S., Cobb, G., Kavanagh, T.J. (2004). Metallothionein and glutamate cysteine ligase gene expression in metal exposed deer mice. Toxicol. Sci. 78(1S):279a
  135. Bekris, L.M.*, Shepard, C., Farin, F.M., Graham, Mcneney, Kavanagh, T.J. and Lernmark, A. (2004). Glutathione S-transferase polymorphisms and association with T1DM. Toxicol. Sci. 78(1S):967a
  136. Leaman, S.M.*, Vliet, P.A.*, Luchtel, D.L., Rosenfeld, M.E. and Kavanagh, T.J. (2004). Effects of particulate matter on glutamate cysteine ligase in RAW cells. Toxicol. Sci. 78(1S):1387a.
  137. Botta, D.*, Shi, S.*, White, C.C.*, Chatterton-Kirchmeier, S.*, Vliet, P.A.* and Kavanagh, T.J. (2004). Inducible glutamate-cysteine ligase transgenic mice exhibit protection against acetaminophen induced liver injury. Toxicol. Sci. 78(1S):1498a.
  138. Shi, S.*, Botta, D.*, White, C.C.*, Vliet, P.A.*, Chatterton-Kirchmeier, S.* and Kavanagh, T.J. Protection effects of enhanced glutathione synthesis on TNFa-induced hepatotoxicity in glutamate-cysteine ligase transgenic mice. Toxicol. Sci. 78(1S):2013a
  139. McConnachie, L.*, Hudson, F.N.*, Ware, C.B., Fernandez, C.*, Vliet, P.A*., White, C.C.* and Kavanagh, T.J. (2004). Generation and characterization of a glutamate-cysteine ligase modifier subunit null mouse. Toxicol. Sci. 78(1S):2018a
  140. LaVire, H.M.*, Srinouanprachanh, S., Quigley, S.D., Beyer, R.P., Bammler, T.K., Hooper, M.J., Farin, F.M. and Kavanagh, T.J. (2004). Alterations in global gene expression in heavy metal exposed deer mice from Anaconda, Montana. Society of Environmental Toxicology and Chemistry, 4th World Congress, Portland, OR. PH:171a
  141. Kavanagh, T.J. (2004). Analytical cytology enhancements to toxicogenomic analysis. Bi-Annual Meeting of the NIEHS Toxicogenomics Research Consortium: Current and Future Issues in Toxicogenomics for Academia, Government and Industry. Chapel Hill, NC
  142. Botta, D.*, Shi, S.*, Beyer, R.P., Bammler, T.K. and Kavanagh, T.J. (2004). Comparative gene expression analysis in glutamate-cysteine ligase transgenic mice exposed to acetaminophen and carbon tetrachloride. Bi-Annual Meeting of the NIEHS Toxicogenomics Research Consortium: Current and Future Issues in Toxicogenomics for Academia, Government and Industry. Chapel Hill, NC
  143. McConnachie, L.*, Beyer, R.P., Fernandez, C.*, Mohar, I.*, Bammler, T.K and Kavanagh, T.J. (2004). Acetaminophen induced gene expression alterations in a GCLM-null mouse model. Bi-Annual Meeting of the NIEHS Toxicogenomics Research Consortium: Current and Future Issues in Toxicogenomics for Academia, Government and Industry. Chapel Hill, NC
  144. McConnachie, L.M.*, Fernandez, C.*, Mohar, I.*, Pierce, R. and Kavanagh, T.J. (2005). Acetaminophen induced hepatoxicity in a GCLM-null mouse model. Toxicol. Sci. 84(S1): 225a.
  145. Shi, S.*, Botta, D.*, Bammler, T., Beyer, R.P. and Kavanagh, T.J., (2005). Prediction of transcription factors commonly affected by glutamate-cysteine ligase expression in mice exposed to acetaminophen, carbon tetrachloride or tumor necrosis factor. Toxicol. Sci. 84(S1): 579a.
  146. Ho, H., White, C.*, Fernandez, C.*, Fausto, N., Kavanagh, T., Nelson, S. and Bruschi, S. (2005). Nrf2 activation involves an oxidative stress independent pathway in tetrafluorocysteine-induced cytotoxicity. Toxicol. Sci. 84(S1): 813a.
  147. Bekris, L.M.*, Janer, M., Kavanagh, T.J. and Lernmark, A. (2005). The glutamate cysteine ligase catalytic subunit –129 C/T single nucleotide polymorphism is associated with the level of GAD65 autoantibodies in type 1 diabietes patients with a delayed age at onset. Toxicol. Sci. 84(S1): 1271a.
  148. Mohar, I.*, McConnachie, L.M.*, Fernandez, C.* and Kavanagh, T.J. (2005). Effect of acetaminophen on cytosolic and mitochondrial glutathione in the livers of wild type, GCLM heterozygous and GCLM null mice. Toxicol. Sci. 84(S1)
  149. Peck, EC*, Botta, D*, Beyer, RP, Bammler, TK, Lobenhofer, EK, Freedman and Kavanagh, TJ. (2005) Differential Gene Expression and Transcription Factor Binding Site Analysis in Livers of C57/B6 Mice Exposed to Cadmium Chloride. Bi-Annual Meeting of the NIEHS Toxicogenomics Research Consortium: Genotype-to-Phenotype Correlation in Health and Disease. Welches, OR
  150. K. A. Fay*, C. D. Simpson, R. L. Dills, M. H. Paulsen and T. J. Kavanagh. (2006) Acidic extracts of wood smoke particulate matter cause caspase independen apoptosis in mouse RAW and MLE cells. The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 90, Number S-1, 229a.
  151. E. C. Peck*, L. A. McConnachie*, R. P. Beyer, T. K. Bammler, C. Baker, D. Ceballos, P. A. Vliet*, J. A. Stewart, D. L. Luchtel, J. D. Kaufman and T. J. Kavanagh (2006). Differential gene expression in GCLM-null and wild type mice exposed to diesel exhaust. The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 90, Number S-1, 234a.
  152. L. McConnachie*, I. Mohar* and T. J. Kavanagh. (2006). Gender differences in Acetaminophen induced hepatotoxicity in wild-type and GCLM null mice. The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 90, Number S-1, 488a.
  153. D. Botta*, L. A. McConnachie*, C. Fernandez*, P. A. Vliet*, C. C. White* and T. J. Kavanagh. (2006). A Model system to assess the role of modulated glutamate-cysteine ligase in toxicant induced oxidative stress. The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 90, Number S-1, 507a.
  154. C. White*, M. Dabrowski*, C. Fernandez*, D. Botta*, R. Beyer, T. Bammler and T. Kavanagh. (2006). Differential gene expression in hepatocyte subpopulations sorted from acetaminophen treated mice. The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 90, Number S-1, 992a.
  155. G. Giordano, Z. Afsharinejad, T. Kavanagh and L. Costa. (2006). Reactive oxygen species mediate the neurotoxicity induced by organophosphorous insecticides in mouse cerebellar granule cells. The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 90, Number S-1, 1472a.
  156. G. Giordano, C. White*, T. Kavanagh and L. Costa (2006). Low concentrations of domoic acid (DA) induces mitochondrially mediated apoptotic death in mouse cerebellar granule cells. The Toxicologist CD — An official Journal of the Society of Toxicology, Volume 90, Number S-1, 2006a.
  157. G. Giordano; H. M. Klintworth; T. J. Kavanagh; L. G. Costa (2007). Apoptosis induced by low concentrations of domoic acid is mediated by the p38 and JNK MAP kinase pathways in mouse cerebellar granule neurons. The Toxicologist CD — An official Journal of the Society of Toxicology. 520a.
  158. M. R. Garry; S. S. Deeb; T. J. Kavanagh; X. Yu; M. A. Vredevoogd; E. Kim; E. M. Faustman (2007). Differential modulation of stress signaling pathways by cadmium in cultured mouse lung fibroblasts heterozygous for GPx4. The Toxicologist CD — An official Journal of the Society of Toxicology. 308a.
  159. D. Botta*; M. B. McGrath*; H. D. Neff-LaFord*; T. J. Kavanagh (2007). Upregulation of GCLM Expression Restores Glutathione and Protects Against APAP-induced Liver Injury in GCLM Null Mice. The Toxicologist CD — An official Journal of the Society of Toxicology. 252a.
  160. H. Wu; T. J. McBride; J. P. Isanhart; T. J. Kavanagh; M. J. Hooper (2007). Gamma-glutamylcysteine synthetase optimization and use in wildlife chemical effects assessments. The Toxicologist CD — An official Journal of the Society of Toxicology. 347a.
  161. L. M. Corey; C. Baker; E. C. Peck; J. H. Wilkerson; D. L. Luchtel; J. D. Kaufman; T. J. Kavanagh; M. E. Rosenfeld (2007). Plasma Cytokine Levels Are Increased in Older Apolipoprotein E Deficient Mice Following Exposure to Diesel Exhaust. The Toxicologist CD — An official Journal of the Society of Toxicology. 402a.
Review date: 
9/24/2014