Lianne Sheppard, PhD, MSc

Professor, Env. and Occ. Health Sciences (Primary department)
Professor, Biostatistics
Dr. Sheppard is Professor and Assistant Chair of Environmental and Occupational Health Sciences and Professor of Biostatistics. Her current research portfolio includes several studies of air pollution exposures and their neurotoxicant effects. She has a Ph.D. in biostatistics. Her methodologic interests center on observational study methods, exposure modeling, and epidemiology, and; her applied research focuses on the the health effects of occupational and environmental exposures. She is principal investigator of a NIH-funded training grant called Biostatistics, Epidemiologic & Bioinformatics Training in Environmental Health and SURE-EH, a project to promote diversity in the environmental health sciences. She leads the biostatistical cores for several projects and collaborates with DEOHS faculty on air pollution cohort studies, identifying the effects of multipollutant exposures, and studying manganese exposures. She is a member of the Epidemiology editorial board, the Health Effects Institute Review Committee, the EPA Clean Air Scientific Advisory Committee , and has served on the several EPA Scientific Advisory Panels, most recently for the Carcinogenic Potential of Glyphosate. Board Chemical Assessment Advisory Committees for Ethylene Oxide Review and for Toxicological Review of Libby Amphibole Asbestos.

Contact Information

University of Washington
Office: F-672
Box: 357232
Environmental and Occupational Health Sciences
Seattle, WA 98195-7232
Tel: 206-616-2722
Fax: 206-543-3286

Research Interests

  • Air pollution health effects. Occupational epidemiological studies. Estimation of health effects from environmental and occupational exposures. Exposure modeling. Measurement error in health effects studies. Incorporating group information in epidemiologic studies.

In the News

Teaching interests

Exposure modeling; Statistical and research practice to enhance scientific research. Example courses:

ENVH 556: Quantitative Occupational Exposure Analysis
ENVH 583: Developing a Research Proposal
ENVH 570: Environmental and Occupational Epidemiology
BIOST 590: Statistical Consulting
BIOST 532: Ethics for Biostatisticians


PhD, Biostatistics, University of Washington, 1992
MSc, Biostatistics, Johns Hopkins University, 1985


Studies of air pollution exposures and their effects on health. These include MESA Air to assess the effect of long-term exposure to air pollution and the progression of subclinical atherosclerosis, the UW CCAR to study the cardiovascular health effects of near roadway pollution, the "Air pollution, Alzheimer's disease, and the aging brain" study, and several studies to understand the impact of manganese exposure on health.

Statistical methods in environmental and occupational epidemiology.

Selected Publications

Fann N, Kim SY, Olives C, Sheppard L. The Scope and Magnitude of the Public Burden from PM2.5 between 1980 and 2010. Environmental Health Perspectives, 2017, Sept:125(9):97003. DOI:10.1289/EHP507 [Epub 6 Sept 2017]

Kim SY, Olives C, Sheppard L, Sampson PD, Larson TV, Kaufman JD. Historical prediction modeling approach for estimating long-term concentrations of PM2.5 in cohort studies before the 1999 implementation of widespread monitoring. Environmental Health Perspectives, 2017 Jan;125(1):38-46. [Epub 2016 Jun 24] PMCID: PMC5226688.

Bergen S, Sheppard L, Kaufman J, Szpiro AA. Multi-pollutant measurement error in air pollution epidemiology studies arising from predicting exposures with penalized regression splines. Journal of the Royal Statistical Society Series C, 2016 Nov;65(5):731-753. PMID: 27789915

Spector JT, Bonauto DK, Sheppard L, Busch-Isaksen T, Calkins M, Adams D, Lieblich M, Fenske R. A Case-Crossover Study of Heat Exposure and Injury Risk in Outdoor Agricultural Workers. PLOS One, 2016 Oct 7;11(10). PMCID: PMC5055365

Kaufman JD, Adar SD, Barr RG, Budoff M, Burke GL, Curl CL, Daviglus ML, Diez Roux AV, Gassett AJ, Jacobs, Jr DR, Kronmal R, Larson TV, Navas-Acien A, Sampson PD, Sheppard L, Siscovick DS, Stein JH, Szpiro AA, Watson KE. Air Pollution and Acceleration of Coronary Artery Calcification: The Multi-Ethnic Study of Atherosclerosis and Air Pollution. The Lancet, 2016, Aug 13;388(10045):696-704. [Epub 2016 May 24] PMCID: PMC5019949

Adar SD, D'Souza J, Sheppard L, Kaufman JD, Hallstrand TS, Davey ME, Sullivan JR, Jahnke J, Koenig J, Larson TV, Liu LJS. Adopting clean fuels and technologies on school buses: Pollution and health impacts in children. Am J Respir Crit Care Med. 2015 Jun 15;191(12):1413-21. [Epub ahead of print Apr 13]. PMCID: PMC4476560

Keller JP, Olives C, Kim SY, Sheppard L, Sampson PD, Szpiro AA, Oron A, Lindström J, Vedal S, Kaufman JD. A unified spatiotemporal modeling approach for predicting concentrations of multiple air pollutants in the Multi-Ethnic Study of Atherosclerosis and Air Pollution. Environmental Health Perspectives, 2015, Apr;123(4):301-9. [Epub 2014 Nov 14] PMCID: PMC4384200

Lindström J, Szpiro AA, Sampson PD, Oron A, Richards M, Larson T, Sheppard L. A flexible spatio-temporal model for air pollution with spatial and spatio-temporal covariates. Environmental and Ecological Statistics, 2014, 21:411-433. [Epub: Aug 31 2013] PMCID: PMC4174563

Szpiro AA, Paciorek C, Sheppard L. Does more accurate exposure prediction necessarily improve health effect estimates? Epidemiology, 2011, 22:680-685. [Epub Jun 29 2011]. PMCID: PMC3195520

Sheppard L, Burnett RT, Szpiro AA, Kim S-Y, Jerrett M, Pope CA III, Brunekreef B. Confounding and exposure measurement error in air pollution epidemiology, Air Quality, Atmosphere & Health, 2011, Jun;5(2):203-216. [Epub ahead of print March 23 2011]. PMCID: PMC3353104
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