Integrative Environmental Health Sciences Facility Core

Joel Kaufman, Director
Catherine Karr, Director, Clinical & Translational Services Unit
Kathleen Kerr, Director, Bioinformatics & Biostatistics Unit
Ed Kelly, Director, Microphysiological Modeling of Toxicant Response Unit

Contact PersonTheo Bammler, 206-616-7378

Bioinformatics & Biostatistics Services:

  • Comprehensive support and analysis of mRNA and microRNA expression array data and miRNA target prediction
  • Comprehensive support and analysis of biological networks and pathways using numerous packages including: weighted correlation network analysis (WGCNA), gene ontology (GO) analysis, Ingenuity Pathway Analysis (IPA), and gene-set enrichment analysis (GSEA).
  • Assistance in the analysis of methylation profiling data derived from targeted enrichment, bisulfite conversion, and massively parallel sequencing
  • Advanced analysis of proteomics data
  • Advanced analysis of metabolomics data
  • Support for integration of different types of OMICs data
  • Facilitate analysis of RNA-seq and ChIP-seq data generated by massively parallel sequencing
  • General statistical consultation & data analysis
  • Support preparation & review of manuscripts, grant proposals

Clinical & Translational Services:

  • Two-way facilitation of interaction between basic scientists and clinical/translational/population-based scientists, to enable innovative approaches that span disciplines.
  • A dedicated core facility space for clinical testing, physiological testing, and collection and storage of human samples.
  • Assistance with IRB issues, identification of staffing solutions for human subjects research, subject recruitment/screening and retention, laboratory assay coordination and organization and application of toxicokinetic approaches.
  • Help developing repositories of samples from well-characterized populations with specific environmental exposures.

Microphysiological Modeling of Toxicant Response Unit (MMTRU):

The MMTRU provides EDGE investigators access to novel 3D microphysiological system (MPS) models (“organs on a chip”) that utilize human and rodent liver and kidney cells to investigate toxicological responses for candidate xenobiotics. It works with EDGE investigators to develop new MPS models for other human and rodent tissues to explore organ-specific toxicity relevant to the mission of the EDGE (e.g. CNS, germ cells, placenta, respiratory, immune system, cardiomyocytes, induced pluripotent stem cells, etc.).