woman holding up 3 swabs

Cangelosi Lab

Developing innovative diagnostic tools to prevent the spread of tuberculosis and other infectious diseases

Jerry Cangelosi, PhD, leads a research team focused on pathogen detection and the epidemiology of infectious diseases.  

Working with public and private collaborators across the globe, this team has generated 10 patents, two product launches, a start-up company, and over 100 publications on tuberculosis, non-tuberculous mycobacteria (NTM), COVID-19, food- and water-borne pathogens, and health care-associated infections. 

Our goal is to develop innovative tools that make it faster to detect active cases of infectious disease, safer for health care workers to collect samples, and enable mass sampling in community settings such as schools and workplaces. 

Research

Oral swabs for tuberculosis detection: We have developed and validated an alternative method to test for tuberculosis (TB). TB is traditionally diagnosed by testing sputum, which patients cough up. Oral swabs, specifically tongue swabs, are faster and easier to use, and they can be collected from anyone, regardless of whether they have symptoms. In a ground-breaking announcement in February 2026, the World Health Organization (WHO) recommended tongue swab testing in situations where sputum cannot be collected.  

Epidemiology of mycobacterial disease: We pioneered the use of real-time molecular epidemiology to help control tuberculosis outbreaks. We have investigated the spread of M. abscessus among cystic fibrosis patients and risk factors for pulmonary M. avium complex (MAC) disease in HIV-negative adults. 

Molecular viability testing: We developed assays for specific bacterial RNA molecules called ribosomal RNA precursors (pre-rRNA). This method improves the detection of viable TB bacteria in samples from patients undergoing tuberculosis treatment. 

Find the team’s complete publication list on PubMed.

Our team

Jerry Cangelosi 

Lab Director 

Rachel Wood 

Research Scientist 

Renée Codsi 

Graduate Research Assistant 

Alaina M. Olson 

Research Scientist 

Contact us 

Cangelosi Lab 

cangelosilab@uw.edu 

University of Washington School of Public Health 

Department of Environmental & Occupational Health Sciences 

4225 Roosevelt Way NE 

Box 354695 

Seattle, WA 98195 United States 

Self swab for tuberculosis screening research

Instructional videos on how to self swab for tuberculosis screening research 

These videos are designed to guide researchers to collect samples and participants to swab themselves for TB screening research. These educational materials were co-created with our stakeholders. Through community-based participatory design methods, PhD student Renée Codsi worked with migrants in Italy and the healthcare workers who serve them on a user experience study. This information was shared with Copan Italia, who developed and manufactured the tongue swabs. This data guided Codsi’s development of educational materials in partnership with Copan Italia.