Michael E. Rosenfeld, PhD
About
Dr. Rosenfeld is a Professor in DEOHS and has joint appointments in the Dept. Pathology and the Core Faculty of the Graduate Program in Nutritional Sciences. He is the director of the Environmental Pathology/Toxicology training grant, funded by NIEHS. Dr. Rosenfeld's primary research emphasis focuses on the effects of environmental factors on atherosclerosis with an emphasis on arterial macrophages and the stability of advanced atherosclerotic lesions in transgenic hyperlipidemic mouse models. These studies include effects of diesel exhaust, respiratory infection with Chlamydia pneumoniae and nutritional factors such as pro-and anti-oxidants . Dr. Rosenfeld also studies the mechanisms of vascular calcification. This includes the role of chondrocyte-like cells and adventitial sca-1+ mesenchymal stem cells and expression of factors such as osteoprotegerin and the receptor activator of NFkB ligand in the calcification of advanced lesions in uremic hyperlipidemic mice.
Education
- PhD, University of Wisconsin
- MS, University of Vermont
- BA, Grinnell College
Affiliations
Mentorship
Not available to mentor new PhD and Master's students.
DEOHS Students Mentored
Association Between In-Utero Exposure to Diesel Exhaust and N-acetyl-cysteine Supplementation in Hyperlipidemic Pregnant Mice and Development of Atherosclerosis at Multiple Vascular Sites in the Offspring
Divya Ravi | MPH | 2016 | View
Research
Interests: Atherogenesis. Diesel exhaust. Health effects of air pollution. Chlamydia pneumoniae vascular calcification. Chronic kidney disease. Cardiovascular disease and traffic. Food additives and contaminants. Genetic susceptibility to toxins.
Projects
Study of the combined effects of diesel exhaust exposure and C. pneumoniae infection on atherosclerosis in hyperlipidemic mice, the effects of in-utero exposure to diesel exhaust on atherosclerosis in adulthood in hyperlipidemic mice, and the roles of OPG and RANKL on vascular calcification in chronic kidney disease.
Publications
Selected publications
- Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association
- In Utero Exposure of Hyperlipidemic Mice to Diesel Exhaust: Lack of Effects on Atherosclerosis in Adult Offspring Fed a Regular Chow Diet
- Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis.