Student Research: Ingrid K. Borroz

, , 1991
Faculty Advisor: David L. Eaton

Development and Utilization of a cDNA Probe for Gamma-Glutamylcysteine Synthetase to Study Transcriptional Regulation of Glutathione Biosynthesis


Glutathione (GSH) is a cellular component which is widely distributed in animal tissues, plants and microorganisms. Despite its simple tripeptide structure, it is known to perform numerous important cellular functions, many of which are not yet fully understood. As the most abundant low-molecular-weight peptide and the most prevalent cellular thiol, GSH has been extensively studied. Since the aim of this project is to elucidate mechanisms of GSH biosynthesis, this report will not include a comprehensive review of GSH, but will outline the most important characteristics concerning synthesis, selective modification and metabloism of GSH.

Taken from the beginning of thesis.