Michelle Averill, PhD, RD

Lecturer, Env. and Occ. Health Sciences (Primary department)
Dr. Averill received her PhD in Nutritional Sciences from the University of Washington and she now both lectures and researches in the field of nutrition, obesity, and diabetes. Dr. Averill is the clinical coordinator for the Graduate Coordinated Program in Dietetics at the University of Washington and she is a member of several professional organizations, including the American Society of Parenteral and Enteral Nutrition and the Academy of Nutrition and Dietetics.

Contact Information

Office: Raitt 324A
Box: 353410
Tel: 206-221-6554

Research Interests

  • Etiology of obesity associated disorders, Atherosclerosis and insulin resistance, Macrophage biology and inflammation, Atherosclerosis progression, Cardiovascular disease, Lipid and glucose metabolism, Diet-environment interaction and health outcomes, Socio-economic status diet-related health outcomes and obesity, and the effect of diet composition on lipids

Teaching interests

Nutr 562 Acute Care Nutrition
Nutr 559 Orientation to Clinical Practice
Nutr 511 Survey of Advanced Nutrition
Nutr 310 Nutrition Across the Life Course

Education

PhD, Nutritional Science, University of Washington, 2007

Projects

Diet and HDL Composition: the effect of a high fat versus a high carbohydrate meal on the proteome and lipidome in the postprandial state. Urinary sodium-to-potassium ratio and CVD: Study looking at the relationship between sodium and potassium with CVD endpoints, using urinary measures as biomarkers of dietary intake in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Whole Food Tube Feeding Study: pilot randomized controlled trial comparing standard versus whole foods based enteral nutrition formulas in patients undergoing surgery for head and neck cancer. Achievement gap study: determining the extent of an achievement gap in an undergraduate public health science course.
Selected Publications

Peer Reviewed Research Articles

Averill M, Kim EJ, Goodspeed L, Wang S, Subramanian S, den Hartigh L, Tang C, Ding Y, Reardon C, Getz G, Chait A:  The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in  LDLR-null mice.  PLoS One, in press, 2014.

Laura J. den Hartigh, Shari Wang, Leela Goodspeed, YiLei Ding, Michelle Averill, Savitha Subramanian, Tomasz Wietecha, Kevin D. O’Brien, Alan Chait. Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice. PLoS One, in press, 2014

Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW. Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology. 2014 Jun 10:en20141037. [Epub ahead of print] PMID: 24914938

Wei H, Averill MM, McMillen TS, Dastvan F, Mitra P, Subramanian S, Tang C, Chait A, Leboeuf RC. Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice. Nutr Diabetes. 2014 Feb 24;4:e108. PMCID: PMC3940828

Montes VN, Turner MS, Subramanian S, Ding Y, Hayden-Ledbetter M, Slater S, Goodspeed L, Wang S, Omer M, Den Hartigh LJ, Averill MM, O'Brien KD, Ledbetter J, Chait A. T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice. PLoS One. 2013 Jul 2;8(7):e67709. PMID: 23844072

Umemoto T, Han CY, Mitra P, Averill MM, Tang C, Goodspeed L, Omer M, Subramanian S, Wang S, Den Hartigh LJ, Wei H, Kim EJ, Kim J, O'Brien KD, Chait A. Apolipoprotein AI and High-Density Lipoprotein Have Anti- Inflammatory Effects on Adipocytes via Cholesterol Transporters: ATP-Binding Cassette A-1, ATP-Binding Cassette G-1, and Scavenger Receptor B-1. Circ Res. 2013 May 10;112(10):1345-54. PMID: 23501697.

Becker L, Liu NC, Averill MM, Yuan W, Pamir N, Peng Y, Irwin AD, Fu X, Bornfeldt KE, Heinecke JW. Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS One. 2012;7(3):e33297.

Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, Coleman RA, Bornfeldt KE. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E715-24

Averill MM, Barnhart S, Becker L, Li X, Heinecke JW, Leboeuf RC, Hamerman JA, Sorg C, Kerkhoff C, Bornfeldt KE. S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation. Circulation. 2011 Mar 22;123(11):1216-26.
**Editorial pick as one of the most read articles on biomarkers.

Averill MM, Bennett BJ, Rattazzi M, Rodmyre RM, Kirk EA, Schwartz SM, Rosenfeld ME. Neither antioxidants nor genistein inhibit the progression of established atherosclerotic lesions in older apoE deficient mice. Atherosclerosis. 2009 Mar;203(1):82-8.

Bennett BJ, Scatena M, Kirk EA, Rattazzi M, Varon RM, Averill M, Schwartz SM, Giachelli CM, Rosenfeld ME. Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006 Sep;26(9):2117-24

Review Articles

Kerkhoff C, Voss A, Scholzen TE, Averill MM, Zänker KS, Bornfeldt KE Novel insights into the role of S100A8/A9 in skin biology. Exp Dermatol. 2012 Jul 4. doi: 10.1111/j.1600-0625.2012.01571.x. [Epub ahead of print]

Averill MM, Kerkhoff C, Bornfeldt KE. S100A8 and S100A9 in cardiovascular biology and disease. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):223-9.

Averill MM, Bornfeldt KB. Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes. Current Diabetes Reports. 2009 Feb;9(1):18-25

Rosenfeld ME, Averill MM, Bennett BJ, Schwartz SM. Progression and disruption of advanced atherosclerotic plaques in murine models. Current Drug Targets. 2008 Mar;9(3):210-6

Letters to the Editor

Kanter JE, Averill MM, Leboeuf RC, Bornfeldt KE. Diabetes-accelerated atherosclerosis and inflammation. Circulation Research. 2008 Oct 10;103(8):e116-7

Review date: 
10/15/2017