Lianne Sheppard, PhD, MSc

Assistant Chair, Env. and Occ. Health Sciences
Professor, Env. and Occ. Health Sciences (Primary department)
Professor, Biostatistics
Dr. Sheppard is Professor and Assistant Chair of Environmental and Occupational Health Sciences and Professor of Biostatistics. She has a Ph.D. in biostatistics. Her interests center on observational study methods, epidemiology, and the health effects of occupational and environmental exposures. She is principal investigator of a NIH-funded training grant called Biostatistics, Epidemiologic & Bioinformatic Training in Environmental Health. She leads the biostatistical cores for several projects and collaborates with DEOHS faculty on air pollution cohort studies, identifying the effects of multipollutant exposures, and studying manganese exposures. She is a member of the Epidemiology editorial board, the Health Effects Institute Review Committee, the EPA Clean Air Scientific Advisory Committee , and has served on the EPA Scientific Advisory Board Chemical Assessment Advisory Committees for Ethylene Oxide Review and for Toxicological Review of Libby Amphibole Asbestos.

Contact Information

University of Washington
Office: F-672
Box: 357232
Environmental and Occupational Health Sciences
Seattle, WA 98195-7232
Tel: 206-616-2722
Fax: 206-543-3286

Research Interests

  • Air pollution health effect and occupational epidemiological studies, estimation of health effects from environmental and occupational exposures, exposure modeling, measurement error in health effects studies, incorporating group information in epidemiologic studies
  • KEYWORDS: Cardiovascular disease and traffic, Diesel exhaust, Environmental epidemiology; Occupational epidemiology; Exposure modeling; Occupational exposure; Environmental exposure; Biostatistics; Air pollution; Health effects; Manganese exposure

Teaching interests

Exposure modeling; Statistical and research practice to enhance scientific research. Example courses:

ENVH 556: Quantitative Occupational Exposure Analysis
ENVH 583: Developing a Research Proposal
ENVH 570: Environmental and Occupational Epidemiology
BIOST 590: Statistical Consulting
BIOST 532: Ethics for Biostatisticians


PhD, Biostatistics, University of Washington, 1992
MSc, Biostatistics, Johns Hopkins University, 1985


Studies of air pollution exposures and their effects on health. These include MESA Air to assess the effect of long-term exposure to air pollution and the progression of subclinical atherosclerosis, and the UW CCAR to study the cardiovascular health effects of near roadway pollution.

Statistical methods in environmental and occupational epidemiology.

Selected Publications

Kaufman JD, Adar SD, Barr RG,  Budoff M, Burke GL, Curl CL, Daviglus ML, Diez Roux AV, Gassett AJ, Jacobs, Jr DR, Kronmal R, Larson TV, Navas-Acien A, Sampson PD, Sheppard L, Siscovick DS, Stein JH, Szpiro AA, Watson KE.  Air Pollution and Acceleration of Coronary Artery Calcification: The Multi-Ethnic Study of Atherosclerosis and Air Pollution.  The Lancet, in press.

Gassett AJ, Sheppard L, McClelland RL, Olives CS, Kronmal RA, Blaha MJ, Budoff MJ, Kaufman JD.  Risk factors for long term coronary artery calcium progression in the Multi-Ethnic Study of Atherosclerosis.  Journal of the American Heart Association, 2015, 6; 4(8): e001726.

Adar SD, D’Souza J, Sheppard L, Kaufman JD, Hallstrand TS, Davey ME, Sullivan JR, Jahnke J, Koenig J, Larson TV, Liu LJS.  Adopting clean fuels and technologies on school buses: Pollution and health impacts in children.  Am J Respir Crit Care Med. 2015 Jun 15;191(12):1413-21.

Keller JP, Olives C, Kim SY, Sheppard L, Sampson PD, Szpiro AA, Oron A, Vedal S, Kaufman JD.  A unified spatiotemporal modeling approach for predicting concentrations of multiple air pollutants in the Multi-Ethnic Study of Atherosclerosis and Air Pollution.  Environmental Health Perspectives 2015, Apr;123(4):301-9.

Lindström J, Szpiro AA, Sampson PD, Oron A, Richards M, Larson T, Sheppard L.  A flexible spatio-temporal model for air pollution with spatial and spatio-temporal covariates. Environmental and Ecological Statistics 2014; 21:411–433.

Bergen S, Sheppard L, Sampson PD, Young-Kim S, Richards M, Vedal S, Kaufman JD, Szpiro AA. A national prediction model for components of PM2.5 and measurement error corrected health effect inference. Environmental Health Perspectives 2013; Sep;121(9):1017-25.

Seixas NS, Neitzel RL, Stover B, Sheppard L, Feeney P, Mills D, Kujawa SG.  10-year prospective study of noise exposure and hearing damage among construction workers.  Occupational and Environmental Medicine 2012; 69:643-50.

Szpiro AA, Paciorek C, Sheppard L. Does more accurate exposure prediction necessarily improve health effect estimates? Epidemiology 2011; 22:680-685.

Sheppard L, Burnett RT, Szpiro AA, Kim S-Y, Jerrett M, Pope CA III, Brunekreef B.  Confounding and exposure measurement error in air pollution epidemiology. Air Quality, Atmosphere & Health 2011; Jun;5(2):203-216.

Szpiro AA, Sheppard L, Lumley T. Efficient measurement error correction with spatially misaligned data. Biostatistics 2011;12:610-23.

Szpiro AS, Sampson PD, Sheppard L, Lumley T, Adar SD, Kaufman J.  Predicting intra-urban variation in air pollution with complex spatio-temporal dependencies.  Environmetrics 2010; 21: 606–631.

Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson G, Kaufman JD. Long-term exposure to fine particulate matter air pollution and cardiovascular events in women, New England Journal of Medicine 2007; 356:447-458.

Janes H, Sheppard L, Lumley T. Assessing the Health Effects of Air Pollution Using the Case-Crossover Design. Epidemiology 2005; 16:717-26. (see also accompanying editorial pp 715-716)

Sheppard L: Insights on information and bias in group-level studies. Biostatistics 2003; 4:265-278.

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