Dr. Rosenfeld is a Professor in DEOHS and has joint appointments in the Dept. Pathology and the Core Faculty of the Graduate Program in Nutritional Sciences. He is the director of the Environmental Pathology/Toxicology training grant, funded by NIEHS. Dr. Rosenfeld's primary research emphasis focuses on the effects of environmental factors on atherosclerosis with an emphasis on arterial macrophages and the stability of advanced atherosclerotic lesions in transgenic hyperlipidemic mouse models. These studies include effects of diesel exhaust, respiratory infection with Chlamydia pneumoniae and nutritional factors such as pro-and anti-oxidants . Dr. Rosenfeld also studies the mechanisms of vascular calcification. This includes the role of chondrocyte-like cells and adventitial sca-1+ mesenchymal stem cells and expression of factors such as osteoprotegerin and the receptor activator of NFkB ligand in the calcification of advanced lesions in uremic hyperlipidemic mice.