Toxicology

Hair is a unique matrix for metal deposition, as it offers a “timeline” of prior exposures (Stadlbauer et al., 2005). This spatiotemporal relationship of exposures along the hair can make possible the estimation of time and duration of exposures.

Polychlorinated Biphenyls (PCBs) are persistent environmental contaminants that pose a significant public health risk including reproductive toxicity partly because they are endocrine disruptors. The lipophilic nature of PCBs increases the risk of developmental exposure due to placenta and breast milk transfer.

Anthropogenic impacts on marine ecosystems have developed into a dominating and formative force within coastal regions. One of the strongest influences within these coastal anthropogenic zones is the deposition and life cycle of marine plastic waste.

The use of chemical agents to eradicate pests and weeds is prevalent across both developing and developed countries, and it plays a crucial role in the agricultural sector by enhancing crop yields and minimizing losses.

Exposure to per-and poly-fluorinated substances is increasingly in the public eye. The National Academy of Sciences, Engineering and Medicine released a report advising increase surveillance screening for those exposed to high levels.

Human and wildlife communities depend on healthy marine environments to provide myriad resources and support. Harmful algal blooms (HABs), phenomena in which algae rapidly produce large amounts of biomass and often toxins, are becoming more frequent, widespread, and severe.

Commensal rodents are a widespread problem in densely populated cities, where they live in close proximity to humans. These rodents can transmit numerous diseases to humans and domestic animals and are a threat to public health.

Cadmium (Cd) is a ubiquitous toxic heavy metal and an emerging neurotoxicant. While Cd neurotoxicity is increasingly documented in epidemiology and toxicology studies at levels relevant to the general US population, the underlying mechanisms are not yet well understood.

Organophosphate (OP) pesticides are extensively used to support agricultural practices in Washington State. OP exposure is associated with both asthmatic populations and agricultural communities. The objective of this thesis is to investigate the correlation between OP pesticide exposure in agricultural community, with respiratory health outcomes, associated with asthma.

The 2018 Environmental Performance Index (EPI) named air pollution as the number one environmental threat to public health. Traffic-related air pollution (TRAP) is a sizable contributor to global air pollution, and diesel exhaust (DE) is a major source of TRAP (Yale Center for Environmental Law & Policy, 2018).

Intro: Understanding how indoor environments can not only affect but also shape human health is a new area of emerging research. Considering that we spend a large portion of our daily lives indoors, dust is a major complex environmental mixture we are exposed to every day.

Introduction: The expansion of the U.S. cannabis industry has created thousands of new jobs in cultivation, processing and distribution. While little is known about occupational hazards in the Cannabis industry, pilot studies suggest an increased risk of respiratory exposures and associated adverse health outcomes, including immunologic sensitization to Cannabis.

Perfluorinated carboxylic acids (PFCAs) are widespread environmental pollutants for which human exposure has been documented. PFCAs at high doses were known to regulate xenobiotic transporters partly through PPARα and CAR in rodent models. Less is known regarding how various PFCAs at a lower concentration modulate transporters for endogenous substrates such as amino acids in human hepatocytes.

Paraoxonase 2 (PON2), one of three members of the paraoxonase gene family, is a ubiquitously expressed intracellular antioxidant enzyme. Primarily located at the inner mitochondrial membrane, it is thought to maintain redox homeostasis at the mitochondrial level and support proper cellular function.

Dementia has been considered a major global public health priority (WHO, 2012). It is very common in older adults (Alzheimer’s Association, 2015b; Seshadri & Wolf, 2007; Weuve et al., 2014) and characterized by the progressive and irreversible loss of memory and mental abilities (Alzheimer’s Association, 2008).

Regulated bioanalysis plays a critical role in drug development and discovery. Bioanalysis refers to the process of identification and quantification of analytes in biological samples. This is a multistage process that starts with method development, followed by method validation, and ends with data reporting.

Arsenic is a long-lasting environmental contaminant found in food, water, air, and soil. In Washington, there are multiple geographically unique sources of arsenic ranging from natural sources like sediments and groundwater to man-made sources.

Approximately 26% of the total global population is of reproductive age and experiences a menstrual cycle, which equates to about half of the global population who are women (House et al. 2012; Kim 2021). During menstruation, menstrual products are used to collect blood and other vaginal discharge from the vaginal opening.

Biosolids are nutrient-rich residual organic matter derived from wastewater treatment. The majority of biosolids in Washington are land applied, with the remaining landfilled or incinerated. In land application, biosolids are mostly applied on agricultural lands or forests as a soil amendment and fertilizer.