Toxicology

Student Research Project |
The use of chemical agents to eradicate pests and weeds is prevalent across both developing and developed countries, and it plays a crucial role in the agricultural sector by enhancing crop yields and minimizing losses.

Student Research Project |
Exposure to per-and poly-fluorinated substances is increasingly in the public eye. The National Academy of Sciences, Engineering and Medicine released a report advising increase surveillance screening for those exposed to high levels.

Student Research Project |
Human and wildlife communities depend on healthy marine environments to provide myriad resources and support. Harmful algal blooms (HABs), phenomena in which algae rapidly produce large amounts of biomass and often toxins, are becoming more frequent, widespread, and severe.

Student Research Project |
Commensal rodents are a widespread problem in densely populated cities, where they live in close proximity to humans. These rodents can transmit numerous diseases to humans and domestic animals and are a threat to public health.

Student Research Project |
Cadmium (Cd) is a ubiquitous toxic heavy metal and an emerging neurotoxicant. While Cd neurotoxicity is increasingly documented in epidemiology and toxicology studies at levels relevant to the general US population, the underlying mechanisms are not yet well understood.

Student Research Project |
Organophosphate (OP) pesticides are extensively used to support agricultural practices in Washington State. OP exposure is associated with both asthmatic populations and agricultural communities. The objective of this thesis is to investigate the correlation between OP pesticide exposure in agricultural community, with respiratory health outcomes, associated with asthma.

Student Research Project |
The 2018 Environmental Performance Index (EPI) named air pollution as the number one environmental threat to public health. Traffic-related air pollution (TRAP) is a sizable contributor to global air pollution, and diesel exhaust (DE) is a major source of TRAP (Yale Center for Environmental Law & Policy, 2018).

Student Research Project |
Intro: Understanding how indoor environments can not only affect but also shape human health is a new area of emerging research. Considering that we spend a large portion of our daily lives indoors, dust is a major complex environmental mixture we are exposed to every day.

Student Research Project |
Introduction: The expansion of the U.S. cannabis industry has created thousands of new jobs in cultivation, processing and distribution. While little is known about occupational hazards in the Cannabis industry, pilot studies suggest an increased risk of respiratory exposures and associated adverse health outcomes, including immunologic sensitization to Cannabis.

Student Research Project |
Perfluorinated carboxylic acids (PFCAs) are widespread environmental pollutants for which human exposure has been documented. PFCAs at high doses were known to regulate xenobiotic transporters partly through PPARα and CAR in rodent models. Less is known regarding how various PFCAs at a lower concentration modulate transporters for endogenous substrates such as amino acids in human hepatocytes.

Student Research Project |
Paraoxonase 2 (PON2), one of three members of the paraoxonase gene family, is a ubiquitously expressed intracellular antioxidant enzyme. Primarily located at the inner mitochondrial membrane, it is thought to maintain redox homeostasis at the mitochondrial level and support proper cellular function.

Student Research Project |
Dementia has been considered a major global public health priority (WHO, 2012). It is very common in older adults (Alzheimer’s Association, 2015b; Seshadri & Wolf, 2007; Weuve et al., 2014) and characterized by the progressive and irreversible loss of memory and mental abilities (Alzheimer’s Association, 2008).

Student Research Project |
Regulated bioanalysis plays a critical role in drug development and discovery. Bioanalysis refers to the process of identification and quantification of analytes in biological samples. This is a multistage process that starts with method development, followed by method validation, and ends with data reporting.

Student Research Project |
Arsenic is a long-lasting environmental contaminant found in food, water, air, and soil. In Washington, there are multiple geographically unique sources of arsenic ranging from natural sources like sediments and groundwater to man-made sources.

Student Research Project |
Approximately 26% of the total global population is of reproductive age and experiences a menstrual cycle, which equates to about half of the global population who are women (House et al. 2012; Kim 2021). During menstruation, menstrual products are used to collect blood and other vaginal discharge from the vaginal opening.

Student Research Project |
Biosolids are nutrient-rich residual organic matter derived from wastewater treatment. The majority of biosolids in Washington are land applied, with the remaining landfilled or incinerated. In land application, biosolids are mostly applied on agricultural lands or forests as a soil amendment and fertilizer.

Student Research Project |
Phthalates are a class of ubiquitous synthetic chemicals found in commonly used products, leading to widespread human exposure. A growing body of evidence demonstrates the adverse association between phthalates and asthma, a leading chronic condition among children.

Student Research Project |
Glutathione S-transferases (GSTs) are detoxification enzymes important in cellular protection through their metabolism of endogenous and exogenous substrates such as chemotherapeutic agents, insecticides, herbicides, and byproducts of oxidative stress.

Student Research Project |
Liver is a critical organ for nutrient homeostasis and xenobiotic biotransformation.

Student Research Project |
Neurodegenerative disorders, including Alzheimer’s disease (AD) and related dementias (ADRD), affect over 47 million people worldwide, and this number is anticipated to reach 131.5 million by 2050.

Student Research Project |
Global oceans play an important role in many aspects of human life. We build our homes on the shores, take our food from the waters, and create our economies from the wealth of resources in marine waters.

Student Research Project |
Persistent environmental pollutants (POPs), such as polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), are ubiquitously detected in the environment despite removal from commercial and industrial use.

Student Research Project |
Introduction: The incidence rates of non-melanoma skin cancer (NMSC) and cutaneous malignant melanoma are rapidly increasing. While inhaled particulate matter (PM) has been classified as a lung carcinogen, the associations between ambient PM (either PM2.5 and PM10) and skin cancers have not been studied thoroughly.

Student Research Project |
In 2018, 3.2% of adults reported currently using an e-cigarette (vaping) at least once in a 30-day period. 20.8% and 4.9% of high school and middle school students, respectively, also reported using e-cigarettes during that same year.

Student Research Project |
Developmental neurotoxicity (DNT) is one of the least tested health effects of the more than 80,000 chemicals registered for use today. In order to more efficiently test chemicals for DNT, more knowledge is needed on mechanisms that trigger adverse neurodevelopmental outcomes.

Student Research Project |
Using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), this research analyzed human cadaver hair for gadolinium and mice hair samples for cadmium. This project combined fundamental bench science (analytical chemistry and animal studies), and insight into exposures to an emerging contaminant.

Student Research Project |
This dissertation focuses on developing frameworks and supporting evidence for the prioritization of chemicals found in children’s consumer products. Toxic chemicals found in children’s consumer products can impact child health and development.

Student Research Project |
Silver nanoparticles (AgNP) are one of the 84,000 chemicals regulated by the U.S. Environmental Protection Agency’s (US EPA) Toxic Substances Control Act (TSCA) that have yet to be tested for potential respiratory toxicity.

Student Research Project |
Cadmium (Cd) is a ubiquitous toxic heavy metal of high interest to the Superfund initiative. It causes toxic effects to many organs, including kidney, liver, lung, and bone. Cd is also a potential neurotoxicant.

Student Research Project |
Diesel exhaust (DE) is a major contributor to air pollution globally. Fine and ultrafine particulate matter make up a large portion of its components.

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