Lucio G. Costa, PharmD

Professor, Env. and Occ. Health Sciences (Primary department)
The general area of research in Dr. Costa's laboratory is neurotoxicology. Neurotoxic substances may play a role in a number of neurodevelopmental disorders, and in neurological neuropsychiatric and neurodegenerative diseases. Dr. Costa's laboratory is interested in the study of the cellular, biochemical and molecular mechanisms involved in neurotoxicity, utilizing in vivo and in vitro cell culture systems, as well as biochemical, molecular and imaging techniques and transgenic animal models.

Contact Information

Box: 354695
4225 Roosevelt Suite 100
Seattle, WA 98195-
Tel: 206-543-2831

Research Interests

  • Neurotoxicology, , molecular mechanisms of neurotoxicity, biochemical markers of neurotoxicity, children's health, food additives and contaminants, genetic susceptibility, in vitro toxicology, pesticides and children, alcohol, cell-cell interactions in developmental neurotoxicity, toxicology of brominated flame retardants, neurotoxicity of diesel exhaust,, paraoxonase 2, gender-differences in oxidative stress and neurotoxicity, autism related disorders, neurotoxicity of air pollution

    KEYWORDS: Alcohol, Developmental neurotoxicity, Birth defects, Children's health, Food additives & contaminants, Genetic susceptibility to neurotoxicants, In vitro toxicology, Nervous system toxicity, Pesticides, Toxicology, Domoic acid, Polybrominated diphenyl ethers, Oxidative stress, Paraoxonase 1, Paraoxonase 2, organophosphorus insecticides, Food additives & contaminants, Genetic susceptibility to toxins, Reproductive toxicology, Solvents (toxicology & health effects), Autism, Diesel exhaust, Traffic-related air pollution

Teaching interests

ENVH 531 Neurotoxicology (3 credits, Winter Quarter, Even years)
ENVH 516 Toxic Agents: Effects and Mechanisms (3 credits, Spring Quarter)

Education

PharmD, Pharmacology, University of Milan (Italy), 1977

Projects

Studies on the neurotoxicity and developmental neurotoxicity of environmental exposure to traffic-related air pollution (e.g. diesel exhaust) with focus on oxidative stress, neuroinflammation and markers of neurodegenerative diseases. Studies include in vivo exposures in mice, and biochemical, behavioral and immunohistochemical measurements.

Studies on the role of paraoxonase 2 as a determinant of sex-linked differences in susceptibility to neurotoxicity using transgenic mice and in vitro and in vivo approaches.

Studies on the role of paraoxonase 1 in modulating susceptibility to organophosphate toxicity.

Studies on the role of paraoxonase 2 as a determinant of sex-linked differences in susceptibility to neurotoxicity using transgenic mice and in vitro and in vivo approaches.

Studies on the role of paraoxonase 1 in modulating susceptibility to organophosphate toxicity.

Study of the expression and neuroprotective functions of paraoxonase 2 (PON2) in the central nervous system.

Study of the neurotoxic effects of exposure to diesel exhaust
Selected Publications

Research Articles in Refereed Journals

  1. Galli CL, Costa LG, Paoletti R. Risks and benefits of the additives in enology. Industria delle Bevande, 1979; 12:60-64.
  2. Costa LG, Galli CL. Aspetti e problematiche della tossicologia moderna. La Rassegna Clinico-Scientifica 1979; 11-12:3-7.
  3. Galli CL, Marinovich M, Costa LG. Absorption, distribution and excretion of 14C-Carmoisine in mice after oral and intravenous administration. Food Cosmet. Toxicol.1981; 19:413-418.
  4. Costa LG, Schwab BW, Hand H, Murphy SD. Reduced [3H]-quinuclidinylbenzilate binding to muscarinic receptors in disulfoton-tolerant mice. Toxicol. Appl. Pharmacol. 1981; 60:441-450.
  5. Costa LG, Hand H, Schwab BW, Murphy SD. Tolerance to the carbamate insecticide propoxur. Toxicology 1981; 21:267-278.
  6. Costa LG, Schwab BW, Hand H, Murphy SD. Decreased muscarinic binding in the small intestine of mice after treatment with neostigmine. Life Sci. 1981; 16:1675-1682.
  7. Schwab BW, Hand H, Costa LG, Murphy SD. Reduced muscarinic receptor binding in tissues of rats tolerant to the insecticide disulfoton. Neurotoxicol.1981; 2:635-648.
  8. Galli CL, Marinovich M, Costa LG. Placental transfer and tissue localization of 14C-Carmoisine in the pregnant rat. Toxicol. Lett. 1982; 10:255-258.
  9. Galli CL, Marinovich M, Costa LG. The metabolic disposition of 14C-labelled Carmoisine in the rat after oral and intravenous administration. Food Chem. Toxicol. 1982; 20:351-356.
  10. Costa LG, Schwab BW, Murphy SD. Muscarinic receptor alterations following neostigmine treatment. Eur. J. Pharmacol. 1982; 80:275-278.
  11. Costa LG, Doctor SV, Murphy SD. Antinociceptive and hypothermic effects of trimethyltin in mice. Life Sci. 1982; 31:1093-1102.
  12. Doctor SV, Costa LG, Murphy SD. Effect of trimethyltin on chemically induced seizures. Toxicol. Lett. 1982; 13:217-223.
  13. Doctor SV, Costa LG, Kendall DA, Murphy SD. Trimethyltin inhibits uptake of neurotransmitters into mouse forebrain synaptosomes. Toxicol. 1982; 25:213-221.
  14. Sultatos LG, Costa LG, Murphy SD. Factors involved in the differential acute toxicity of the insecticides chlorpyrifos and methylchlorpyrifos in mice. Toxicol.Appl. Pharmacol. 1982; 65:144-152.
  15. Sultatos LG, Costa LG, Murphy SD. Determination of organophosphorus insecticides, their oxygen analogs and metabolites by high performance liquid chromatography. Chromatographia 1982; 15:669-671.
  16. Costa LG, Schwab BW, Murphy SD. Differential alterations of cholinergic
    muscarinic receptors in acute and chronic tolerance to organophosphorus insecticides. Biochem. Pharmacol. 1982; 31:3407-3413.
  17. Costa LG, Murphy SD. Passive avoidance retention in mice tolerant to the organo-phosphorus insecticide disulfoton. Toxicol. Appl. Pharmacol. 1982; 65:451-458.
  18. Fox DA, Wright AA, Costa LG. Visual acuity deficits following neonatal exposure to lead: cholinergic interactions. Neurobehav. Toxicol. Teratol. 1982; 4:689-693.
  19. Costa LG, Schwab BW, Murphy SD. Tolerance to anticholinesterase compounds in mammals. Toxicology 1982; 25:79-97.
  20. Costa LG, Fox DA. A selective decrease of cholinergic muscarinic receptors in the visual cortex of adult rats following developmental lead exposure. Brain Research 1983; 276:259-266.
  21. Costa LG, Murphy SD. Are there muscarinic receptors on erythrocyte membranes? IRCS Med. Sci. 1983; 11:146-147.
  22. Costa LG, Murphy SD. Unidirectional cross-tolerance between the carbamate insecticide propoxur and the organophosphate disulfoton in mice. Fund. Appl.Toxicol. 1983; 3:483-488.
  23. Schwab BW, Costa LG, Murphy SD. Muscarinic receptor alterations as a mech-anism of anticholinesterase tolerance. Toxicol. Appl. Pharmacol. 1983; 71:14-23.
  24. Costa LG, Murphy SD. [3H]-Nicotine binding in rat brain: alteration after chronic acetylcholinesterase inhibition. J. Pharmacol. Exp. Ther. 1983; 226:392-397.
  25. Costa LG, Shao M, Basker K, Murphy SD. Chronic administration of an acetyl-cholinesterase inhibitor to rats alters cholinergic muscarinic receptors in the pancreas. Chem. Biol. Interactions 1984; 48:261-269.
  26. Costa LG, Murphy SD. Antinociceptive effect of the GABAmimetic THIP: Chronic treatment increases alpha2-adrenoceptors in the mouse brain. J. Pharmacol. Exp. Ther. 1984; 229:386-390.
  27. Tragni E, Costa LG, Marinovich M, Galli CL. Application of a radioactivity detector to the analysis of 14C-Carmoisine metabolites by Ion-Pair High Pressure Liquid Chromatography. J. Appl. Toxicol. 1984; 4:105-108.
  28. Costa LG, Murphy SD. Interaction between acetaminophen and organophosphates in mice. Res. Comm. Chem. Pathol. Pharmacol. 1984; 44:389-400.
  29. Costa LG, Murphy SD. Interaction of choline with nicotinic and muscarinic cholin-ergic receptors in the rat brain in vitro. Clin. Exp. Pharmacol. Physiol. 1984; 11:649-654.
  30. Vaught JL, Pelly K, Costa LG, Setler P, Enna SJ. A comparison of the antinociceptive responses to THIP and Baclofen. Neuropharmacol. 1985; 24:211-216.
  31. Costa LG. Inhibition of [3H]-GABA uptake by organotin compounds in vitro. Toxicol. Appl. Pharmacol. 1985; 79:471-479.
  32. Costa LG, Murphy SD. Characterization of muscarinic cholinergic receptors in the submandibular gland of the rat. J. Autonom. Nerv. System, 1985; 13:287-301.
  33. Costa LG, Murphy SD. Antinociceptive effect of diisopropylphospho­fluoridate: development of tolerance and lack of cross-tolerance to morphine. Neurobehav.Toxicol. Teratol. 1985; 7:251-256.
  34. Roney PL, Costa LG, Murphy SD. Conditioned taste aversion induced by organo-phosphate compounds in rats. Pharmacol. Biochem. Behav. 1986; 24:737-742.
  35. Costa LG, Murphy SD. Cholinergic and opiate involvement in the antinociceptive effect of diisopropylfluorophosphate. Pharmacol. Biochem. Behav. 1986; 24:733-736.
  36. Costa LG, Kaylor G, Murphy SD. Carbachol-and norepinephrine-stimulated phosphoinositide metabolism in rat brain: effect of chronic cholinesterase inhibition. J. Pharmacol. Exp. Ther. 1986; 239:32-37.
  37. Costa LG, Murphy SD. Effect of diethylmaleate and other glutathione depletors on protein synthesis. Biochem. Pharmacol. 1986; 35:3383-3388.
  38. Costa LG, Sulaiman R. Inhibition of protein synthesis by trimethyltin. Toxicol.Appl. Pharmacol. 1986; 86:189-196.
  39. Costa LG, Kaylor G, Murphy SD. Interaction of choline with muscarine receptor-stimulated phosphoinositide metabolism in the rat brain. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1986;334:536-539.
  40. Costa LG, Specific binding of [3H]-methylscopolamine to glass fiber filters. J.Pharm. Pharmacol. 1987; 39:239-240.
  41. Costa LG, Murphy SD. Interaction of the pesticide chlordimeform with adrenergic receptors in mouse brain: an in vitro study. Arch. Toxicol. 1987; 59:323-327.
  42. Janigro D, Costa LG. Effects of trimethyltin on granule cells excitability in the in vitro rat dentate gyrus. Neurotoxicol. Teratol. 1987; 9:33-38.
  43. Balduini W, Murphy SD, Costa LG. Developmental changes in muscarinic receptor-stimulated phosphoinositide metabolism in rat brain. J. Pharmacol. Exp. Ther. 1987; 241:421-427.
  44. McDonald BE, Costa LG, Murphy SD. Spatial memory impairment and central muscarinic receptor loss following prolonged treatment with organophosphates. Toxicol. Lett. 1988;40:47-56.
  45. Costa LG, Olibet G, Murphy SD. Alpha2-adrenoceptors as a target for formamidine pesticides: in vitro and in vivo studies in mice. Toxicol. Appl. Pharmacol. 1988; 93:319-328.
  46. Costa LG. Interactions of neurotoxicants with neurotransmitter systems. Toxicology 1988; 49:359-366.
  47. Stamper CR, Balduini W, Murphy SD, Costa LG. Behavioral and biochemical effects of postnatal parathion exposure in the rat. Neurotoxicol. Teratol. 1988;10:261-266.
  48. Costa LG, Kaylor G, Murphy SD. Muscarinic cholinergic binding sites on rat lymphocytes. Immunopharmacol. 1988; 16:139-149.
  49. Costa LG, Olibet G, Wu DS, Murphy SD. Acute and chronic effects of the pesticide Amitraz on alpha2-adrenoceptors in the mouse brain. Toxicol. Lett. 1989; 47:135-143.
  50. Balduini W, Costa LG. Effects of ethanol on muscarinic receptor-stimulated phosphoinositide metabolism during brain development. J. Pharmacol. Exp. Ther.1989; 250:541-547.
  51. Furlong CE, Richter RJ, Seidel SL, Costa LG, Motulsky AG. Spectrophotometric assays for the enzymatic hydrolysis of the active metabolites of chlorpyrifos and parathion by plasma paraoxonase/arylesterase. Anal. Biochem. 1989; 180: 242-247.
  52. Costa LG, Wu DS, Olibet G, Murphy SD. Formamidine pesticides and alpha2-adrenoceptors: studies with amitraz and chlordimeform in rats and development of a radioreceptor binding assay. Neurotoxicol. Teratol. 1989; 11:405-411.
  53. Tonini M, Costa LG, Candura SM, Olibet G, Rizzi CA, Garlaschelli L, Manzo L. Interaction of the pyrethroid insecticides tetramethrin and cypermethrin with enteric cholinergic transmission in the guinea pig. NeuroToxicology 1989; 4: 707-716.
  54. Balduini W, Costa LG, Murphy SD. Potassium ions potentiate the muscarinic receptor-stimulated phosphoinositide metabolism in cerebral cortex slices: a comparison of neonatal and adult rats. Neurochem. Res. 1990; 15: 33-39.
  55. Costa LG, Kaylor G, Murphy SD. In vitro and in vivo modulation of cholinergic muscarinic receptors in rat lymphocytes and brain by cholinergic agents. Int. J. Immunopharmacol. 1990; 12: 67-76.
  56. Costa LG, McDonald BE, Murphy SD, Omenn GS, Richter RJ, Motulsky AG, Furlong CE. Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats. Toxicol. Appl. Pharmacol. 1990; 103:66-76.
  57. Balduini W, Costa LG. Developmental neurotoxicity of ethanol: in vitro inhibition of muscarinic receptor-stimulated phosphoinositide metabolism in brain from neonatal but not adult rats. Brain Research, 1990; 512: 248-252.
  58. Maier WE, Costa LG. Na+/K+-ATPase in rat brain and erythrocytes as a possible target and marker, respectively, for neurotoxicity: studies with chlordecone, organotins and mercury compounds. Toxicol. Lett. 1990; 51: 175-188.
  59. Balduini W, Murphy SD, Costa LG. Characterization of cholinergic muscarinic receptor-stimulated phosphoinositide metabolism in brain from immature rats. J. Pharmacol. Exp. Ther. 1990; 253: 573-579.
  60. Costa LG. The phosphoinositide/protein kinase C system as a target for neurotoxicity. Pharmacol. Res. 1990; 22:393-408.
  61. Calleman CJ, Bergmark E, Costa LG. Acrylamide is metabolized to glycidamide in the rat: evidence from hemoglobin adduct formation. Chem. Res. Toxicol. 1990; 3:406-412.
  62. Balduini W, Costa LG. Characterization of ouabain - induced phosphoinositide hydrolysis in brain slices of the neonatal rat. Neurochem. Res. 1990; 15:1023-1029.
  63. Candura SM, Coccini T, Manzo L, Costa LG. Interaction of sigma compounds with receptor-stimulated phosphoinositide metabolism in rat brain. J. Neurochem. 1990; 55:1741-1748.
  64. Wu DS, Costa LG, Murphy SD. The effects of pesticides - CDM and AMZ - on inhibition of the binding of 3H- clonidine to alpha2- adrenoceptors in rat forebrain tissue. Hua Hsi I Ko Ta Hsueh Hsueh Pao (J. West China Univ. Med. Sci.) 1990; 21:17-21 (in chinese).
  65. Candura SM, Balduini W, Costa LG. Interaction of short chain alipathic alcohols with muscarinic receptor-stimulated phosphoinositide metabolism in cerebral cortex from neonatal and adult rats. NeuroToxicology 1991; 12:23-32.
  66. Trenga CA, Kunkel DD, Eaton DL, Costa LG. Effect of styrene oxide on rat brain glutathione. NeuroToxicology 1991; 12:165-178.
  67. Costa LG, Gastel J, Murphy SD. The formamidine pesticides chlordimeform and amitraz decrease hepatic glutathione in mice through an interaction with alpha2- adrenoceptors. J. Toxicol. Environ. Health. 1991; 33:349-358.
  68. Coccini T, Costa LG, Manzo L, Candura SM, Iapadre N, Balestra B, Tonini M. Two subtypes of enteric non opioid sigma receptors in guinea-pig cholinergic motor neurons. Eur. J. Pharmacol. 1991; 198:105-108.
  69. Balduini W, Candura SM, Manzo L, Cattabeni F, Costa LG. Time-, concentration-, and age- dependent inhibition of muscarinic receptor- stimulated phosphoinositide metabolism by ethanol in the developing rat brain. Neurochem. Res. 1991; 16:1235-1240.
  70. Wechsler LS, Checkoway H, Franklin GM, Costa LG. A pilot study of occupational and environmental risk factors for Parkinson’s disease. NeuroToxicology 1991; 12:387-392.
  71. Balduini W, Candura SM, Costa LG. Regional development of carbachol-, glutamate-, norepinephrine-, and serotonin- stimulated phosphoinositide metabolism in rat brain. Dev. Brain Research 1991; 62:115-120.
  72. Manzo L, Candura SM , Balduini W, Costa LG. Developmental neurotoxicity of alcohol. J. Toxicol. Clin. Exp.1991; 5:295-297.
  73. Coccini T, Manzo L, Costa LG. 3H-Spiperone labels sigma receptors, not dopamine D2receptors, in rat and human lymphocytes. Immunopharmacology 1991; 22:93-106.
  74. Rosenstock L, Keifer M, Daniell WE, McConnell R, Claypole K and the Pesticide Health Effects Study Group (Barnhart S, Costa LG, Demers P, Eaton D, Morris S, Murphy SD). Chronic central nervous system effects of acute organophosphate pesticide intoxication. Lancet 1991; 338:223-227.
  75. Bergmark E, Calleman CJ, Costa LG. Formation of hemoglobin adducts of acrylamide and its epoxide metabolite glycidamide in the rat. Toxicol. Appl. Pharmacol. 1991; 111:352-363.
  76. Candura SM, Castoldi AF, Manzo L, Costa LG. Interaction of aluminum ions with phosphoinositide metabolism in rat cerebral cortical membranes . Life Sciences 1991; 49:1245-1252.
  77. Castoldi AF, Fitzgerald B, Manzo L, Tonini M, Costa LG. Muscarinic M2 receptors in rat brain labeled with 3H-AFDX 384. Res. Comm. Chem. Pathol. Pharmacol. 1991; 74:371-374.
  78. Costa LG, Gregotti C, Manzo L, Faustman EM, Bergmark E, Calleman CJ. Comparative studies on the neuro- and reproductive toxicity of acrylamide and its epoxide metabolite glycidamide in the rat. NeuroToxicology 1992; 13:219-224.
  79. Candura SM, Manzo L, Costa LG. Inhibition of muscarinic receptor and G- protein dependent phosphoinositide metabolism in cerebrocortical membranes from neonatal rat by ethanol. NeuroToxicology 1992; 13:281-288.
  80. Checkoway H, Costa LG, Camp J, Coccini T, Daniell WE, Dills RL. Peripheral markers of neurochemical function among styrene-exposed workers. Br. J. Ind. Med. 1992; 49:560-565.
  81. Gregotti C, Di Nucci A, Costa LG, Manzo L, Scelsi R, Berte‘ F, Faustman EM. Effects of thallium on primary cultures of testicular cells. J. Toxicol. Env. Health 1992; 36:59-69.
  82. Dypbukt JM, Costa LG, Manzo L, Orrenius S, Nicotera P. Toxic and mutagenic effects of styrene -7,8-oxide in neuroadrenergic PC 12 cells. Carcinogenesis 1992; 13:417-424.
  83. Calleman CJ, Stern LG, Bergmark E, Costa LG. Linear vs. non-linear models for hemoglobin adduct formation by acrylamide and its metabolite glycidamide: implications for risk estimation. Cancer Epidemiol. Biomarkers Prev. 1992; 1:361- 368.
  84. Candura SM, Castoldi AF, Manzo L, Costa LG. Guanine nucleotide- and muscarinic agonist- dependent phosphoinositide metabolism in synaptoneurosomes from cerebral cortex of immature rats. Neurochem. Res. 1992; 17:1133-1141.
  85. Checkoway H, Costa LG, Woods JS, Castoldi AF, Lund BO, Swanson PD. Peripheral blood cell activities of monoamine oxidase B and superoxide dismutase in Parkinson’s disease. J. Neural Transm. P.D. Section. 1992; 4:283-290.
  86. Furlong CE, Costa LG, Hassett C, Richter RJ, Sundstrom JA, Adler DA, Disteche CM, Omiecinski CJ, Chapline C, Crebb JW, Humbert R. Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification. Chem. Biol. Inter. 1993; 87:35- 48.
  87. Candura SM, Marracini P, Costa LG, Manzo L, Rossi A, Coccini T, Tonini M. Calcium entry blockade as a mechanism for chlordimeform - induced inhibition of motor activity in the isolated guinea - pig ileum. Pharmacol. Toxicol. 1992; 71:426-433.
  88. Karr C, Demers P, Costa LG, Daniell WE, Barnhart S, Miller M, Gallagher G, Horstman T, Eaton DL, Rosenstock L. Organophosphate pesticide exposure in a group of Washington State orchard applicators. Env. Research 1992; 59:229-237.
  89. Daniell WE, Barnhart S, Demers P, Costa LG, Eaton DL, Miller M, Rosenstock L. Neuropsychological performance among agricultural pesticide applicators. Env. Research 1992; 59:217-228.
  90. Fitzgerald BB, Costa LG. Modulation of M1and M2muscarinic receptor subtypes following repeated organophosphate exposure in rat. Toxicol. Appl. Pharmacol. 1992; 117:122-125.
  91. Koenig JQ, Costa LG, Kaylor G. Lymphocyte beta-adrenoceptors, asthma and ethnicity. Lancet 1992; 340:738.
  92. Tan XX, Tang C, Castoldi AF, Manzo L, Costa LG. Effects of inorganic and organic mercury on intracellular calcium levels in rat T-lymphocytes. J. Toxicol. Env. Health 1993; 38:159-170.
  93. Calleman CJ, Bergmark E, Stern LG, Costa LG. A nonlinear dosimetric model for hemoglobin adduct formation by the neurotoxic agent acrylamide and its genotoxic metabolite glycidamide. Env. Hlth. Persp. 1993; 99:221-223.
  94. Fitzgerald BB, Costa LG. Modulation of muscarinic receptors and acetylcholinesterase activity in lymphocytes and in brain areas following repeated organophosphate exposure in rats. Fund. Appl. Toxicol. 1993; 20:210-216.
  95. Manzo L, Costa LG, Tonini M, Minoia C, Sabbioni E. Metabolic studies as a basis for the interpretation of metal toxicity. Toxicol Lett. 1992;64/65:677-686.
  96. Castoldi AF, Manzo L, Costa LG. Cyclic GMP formation induced by muscarinic receptors is mediated by nitric oxide synthesis in rat cortical primary cultures. Brain Research 1993; 610:57-61.
  97. Bergmark E, Calleman CJ, He F, Costa LG. Determination of hemoglobin adducts in humans occupationally exposed to acrylamide. Toxicol. Appl. Pharmacol.1993; 120:45-54.
  98. Coccini T, Candura SM, Manzo L, Costa LG, Tonini M. Interaction of the neurotoxic pesticides ivermectin and lindane with the enteric GABAAreceptor - ionophore complex in the guinea - pig. Eur. J. Pharmacol. Environ. Toxicol. Sect. 1993; 248:1-6.
  99. Tan XX, Castoldi AF, Manzo L, Costa LG. Interaction of ethanol with muscarinic receptor - stimulated phosphoinositide metabolism during the brain growth spurt in the rat: role of acetaldehyde. Neurosci. Lett. 1993; 156:13-16.
  100. Deng H, He F, Zhang S, Calleman CJ, Costa LG. Quantitative measurements of vibration threshold in healthy adults and acrylamide workers. Int. Arch. Occup. Env. Health 1993; 65:53-56.
  101. Li WF, Costa LG, Furlong CE. Serum paraoxonase status: a major factor in determining resistance to organophosphates. J. Toxicol. Env. Hlth. 1993; 40:337- 346.
  102. Tang C, Castoldi AF, Costa LG. Effects of the muscarinic agonists oxotremorine on membrane fluidity in rat lymphocytes. Biochem. Mol. Biol. Internat. 1993; 29:1047-1054.
  103. Castoldi AF, Costa LG, Manzo L. Oncogenes as indicators of occupational exposure to carcinogenic agents. G. It. Med. Lav. 1993; 15:45-50.
  104. Costa LG. Signal transduction mechanisms in developmental neurotoxicity: the phosphoinositide pathway. NeuroToxicology 1994; 15:19-28.
  105. Manzo L, Locatelli C, Candura SM, Costa LG. Nutrition and alcohol neurotoxicity. NeuroToxicology 1994; 15:555-565.
  106. Costa P, Castoldi AF, Traver DJ, Costa LG. Lack of m2muscarinic acetylcholine receptor mRNA in rat lymphocytes. J. Neuroimmunol. 1994; 49:115-124.
  107. Balduini W, Renò F, Costa LG, Cattabeni F. Developmental neurotoxicity of ethanol: further evidence for an involvement of muscarinic receptor - stimulated phosphoinositide metabolism. Eur. J. Pharmacol. Mol. Pharmacol. Sect.1994; 266:283-289.
  108. Tan XX, Costa LG. Inhibition of muscarinic receptor - stimulated phosphoinositide metabolism by cocaine, norcocaine and cocaethylene in rat brain. Dev. Brain Res. 1994; 79:132-135.
  109. Ehrich M, Intropido L, Costa LG. Interaction of organophosphorus compounds with muscarinic receptors in SH-SY5Y human neuroblastoma cells. J. Toxicol. Env. Health 1994; 43:51-63.
  110. Calleman CJ, Wu Y, He F, Tian G, Bergmark E, Zhang S, Deng H, Wang Y, Crofton KM, Fennell T, Costa LG. Relationship between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide. Toxicol. Appl. Pharmacol. 1994; 126:361-371.
  111. Costa P, Traver DJ, Auger CB, Costa LG. Expression of cholinergic muscarinic subtypes mRNA in rat blood mononuclear cells. Immunopharmacology 1994; 28:113-124.
  112. Castoldi AF, Coccini T, Rossi A, Nicotera P, Costa LG, Tan XX, Manzo L. Biomarkers in environmental medicine: alterations of cell signalling as early indicators of neurotoxicity. Funct. Neurol. 1994 ; 9:101-109.
  113. Gregotti CF, Kirby Z, Manzo L, Costa LG, Faustman EM. Effects of styrene oxide on differentiation and viability of rodent embryo cultures. Toxicol. Appl. Pharmacol. 1994; 128:25-35.
  114. Checkoway H, Echeverria D, Moon J-D, Heyer N, Costa LG. Platelet monoamine oxidase B activity in workers exposed to styrene. Int. Arch. Occup. Env. Health 1994; 66:359-362.
  115. Renò F, Tan XX, Balduini W, Costa LG. Administration of ethanol during the rat’s brain growth spurt causes dose - dependent microencephaly and inhibition of muscarinic receptor - stimulated phosphoinositide metabolism. Res. Comm. Alcoh. Subst. Abuse 1994; 15:141-150.
  116. Tan XX, Costa LG. Long lasting microencephaly following exposure to cocaine during the brain growth spurt in the rat. Dev. Brain Research 1995; 84:179-184.
  117. Li WF, Furlong CE, Costa LG. Paraoxonase protects against chlorpyrifos toxicity in mice. Toxicol. Lett. 1995; 76:219-226.
  118. Costa LG, Manzo L. Biochemical markers of neurotoxicity: research strategies and epidemiological applications. Toxicol. Lett. 1995; 77: 137-144.
  119. Manzo L, Castoldi AF, Coccini T, Rossi AD, Nicotera P, Costa LG. Mechanisms of neurotoxicity. Applications to biological monitoring. Toxicol. Lett. 1995; 77:63-72.
  120. Balduini W, Renò F, Costa LG. Interaction of ethanol and anoxia with muscarinic receptor - stimulated phosphoinositide metabolism during brain development. Life Sciences 1995; 57:1667-1674.
  121. Costa LG, Deng H, Calleman CJ, Bergmark E. Evaluation of the neurotoxicity of glycidamide, an epoxide metabolite of acrylamide: behavioral, neurochemical and morphological studies. Toxicology 1995; 98:151-161.
  122. Tan XX, Costa LG. Postnatal development of muscarinic receptor - stimulated phosphoinositide metabolism in mouse cerebral cortex: sensitivity to ethanol. Dev. Brain Research 1995; 86:348-353.
  123. Candura SM, Tonini M, Baiardi P, Manzo L, Costa LG. Heterogeneity of cholinergic muscarinic receptors coupled to phosphoinositide metabolism in immature rat brain. Dev. Brain Research 1995; 86:134-142.
  124. Segerback D, Calleman CJ, Schroeder JL, Costa LG, Faustman EM. Formation of N-7-(2-carbamoyl-2-hydroxyethyl) guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C] acrylamide. Carcinogenesis 1995; 16:1161-1165.
  125. Costa P, Auger CB, Traver DJ, Costa LG. Identification of m3, m4and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells. J. Neuroimmunol. 1995; 60:45-51.
  126. Kovacs KA, Kavanagh TJ, Costa LG. Ethanol inhibits muscarinic receptor - stimulated phosphoinositide metabolism and calcium mobilization in rat primary cortical cultures. Neurochem. Res. 1995; 20:939-949.
  127. Costa LG, Balduini W, Renò F. Muscarinic receptor stimulation of phospholipase D activity in the developing brain. Neurosci. Res. Comm. 1995; 17:169-176.
  128. Coccini T, DiNucci A, Tonini M, Maestri L, Costa LG, Liuzzi M, Manzo L. Effects of ethanol administration on cerebral non-protein sulfhydryl content in rats exposed to styrene vapour. Toxicology 1996; 106:115-122.
  129. Costa LG. Biomarker research in neurotoxicology: the role of mechanistic studies to bridge the gap between the laboratory and epidemiological investigations. Env. Health Persp. 1996; 104 (Suppl. I):55-67.
  130. Guizzetti M, Costa P, Peters J, Costa LG. Acetylcholine as a mitogen: muscarinic receptor - mediated proliferation of rat astrocytes and human astrocytoma cells. Eur. J. Pharmacol. 1996; 297:265-273.
  131. Castoldi AF, Candura SM, Costa P, Manzo L, Costa LG. Interaction of mercury compounds with muscarinic receptor subtypes in the rat brain. NeuroToxicology 1996; 17:735-742.
  132. Manzo L, Artigas F, Martinez E, Mutti A, Bergamaschi E, Nicotera P, Tonini M, Candura SM, Ray DE, Costa LG. Biochemical markers of neurotoxicity: a review of mechanistic studies and applications. Human Exp. Toxicol. 1996; (Suppl. I):S20-S35.
  133. Yagle K, Costa LG. Effects of organophosphate exposure on muscarinic acetylcholine receptor subtype mRNA levels in the adult rat. NeuroToxicology 1996; 17:523-530.
  134. Coccini T, Maestri L, Robustelli della Cuna FS, Li B, Costa LG, Manzo L. Urinary mercapturic acid diastereoisomers in rats subchronically exposed to styrene and ethanol. Arch. Toxicol. 1996; 70:736-741.
  135. Guizzetti M, Costa LG. Inhibition of muscarinic receptor - stimulated glial cell proliferation by ethanol. J. Neurochem. 1996; 67:2236-2245.
  136. Costa P, Checkoway H, Levy D, Smith-Weller T, Franklin GM, Swanson PD, Costa LG. Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson’s disease. Am. J. Med. Genetics (Neuropsych. Genet.) 1997; 74: 154-156.
  137. Li WF, Matthews C, Disteche CM, Costa LG, Furlong CE. Paraoxonase (Pon1) gene in mice: sequencing, chromosomal localization and developmental expression. Pharmacogenetics 1997; 7: 137-144.
  138. Gafni J, Munsch JA, Lam TH, Catlin MC, Costa LG, Molinski TF, Pessah IN. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5- trisphosphate receptor calcium pore. Neuron 1997; 19: 723-733.
  139. Guizzetti M, Catlin M, Costa LG. Effects of ethanol on glial cell proliferation: relevance to the fetal alcohol syndrome. Front. Biosci. 1997; 2: e93-98.
  140. Costa LG. Neurotoxicity testing: a discussion of in vitro alternatives. Env. Health Persp. 1998; 106 (Suppl. 2): 505-510.
  141. Costa LG. Signal transduction in environmental neurotoxicity. Annu. Rev. Pharmacol. Toxicol. 1998; 38: 21-43.
  142. Checkoway H, Farin FM, Costa-Mallen P, Kirchner S, Costa LG. Genetic polymorphisms in Parkinson’s disease. NeuroToxicology 1998; 19: 635-644.
  143. Furlong CE, Li WF, Costa LG, Richter RJ, Shih DM, Lusis AJ. Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human Pon1 polymorphism. NeuroToxicology 1998; 19: 645-650.
  144. Checkoway H, Franklin GM, Costa-Mallen P, Smith-Weller T, Dilley J, Swanson PD, Costa LG. A genetic polymorphism of MAO B modifies the association of cigarette smoking and Parkinson’s disease. Neurology 1998; 50: 1458-1461.
  145. Alexander BH, Checkoway H, Costa-Mallen P, Faustman EM, Woods JS, Kelsey KT, van Netten C, Costa LG. Interaction of blood lead and d-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. Env. Health Persp. 1998; 106: 213-216.
  146. Spielman H, Bochkov NP, Costa LG, Gribaldo L, Guillouzo A, Heindel JJ, Karol M, Parchment R, Pfaller W, Peraita PP, Zacharewski T. Alternative testing methodologies for organ toxicity. Env. Health Persp. 1998; 106 (Suppl. 2): 427-439.
  147. Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 1998; 394: 284- 287.
  148. Bordin S, Costa LG, Tan XX. Fibroblast heterogeneity of signal transduction mechanisms to complement-C1q. Analyses of calcium mobilization, inositol phosphate accumulation and protein kinase C redistribution. J. Periodontol. 1998; 69: 642-649.
  149. Guizzetti M, Wei M, Costa LG. The role of protein kinase C a and e isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line. Eur. J. Pharmacol. 1998; 359: 223-233.
  150. Castoldi AF, Barni S, Randine G, Costa LG, Manzo L. Ethanol selectively interferes with the trophic action of NMDA and carbachol on cultured cerebellar granule cells undergoing apoptosis. Dev. Brain Res. 1998; 111:279-289.
  151. Coccini T, Fenoglio C, Maestri L, Costa LG, Manzo L. Effect of subchronic ethanol ingestion on styrene-induced damage to the tracheal and pulmonary epithelium of the rat. J. Appl. Toxicol. 1998; 18: 349-356.
  152. Costa LG. Biochemical and molecular neurotoxicology: relevance to biomarker development, neurotoxicity testing and risk assessment. Toxicol. Lett. 1998; 103: 417-421.
  153. Catlin MC, Guizzetti M, Costa LG. Effects of ethanol on calcium homeostasis in the nervous system: implications for astrocytes. Mol. Neurobiol. 1999; 19: 1-24.
  154. Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (Pon1) in the detoxication of organophosphates and its human polymorphism. Chem. Biol. Interact. 1999; 119-120: 429-438.
  155. Costa LG, Guizzetti M. Muscarinic cholinergic receptor signal transduction as a potential target for the developmental neurotoxicity of ethanol. Biochem. Pharmacol. 1999; 57:721-726.
  156. Coccini T, Randine G, Bi L, Manzo L, Costa LG. Effect of styrene on monoamine oxidase B activity in rat brain. J. Toxicol. Env. Health 1999; 56: 59-68.
  157. Yagle K, Costa LG. Effects of alcohol on immediate-early gene expression in primary culture of rat cortical astrocytes. Alcoh. Clin. Exp. Res. 1999; 23: 446-455.
  158. Costa LG. The emerging field of ecogenetics. Neurotoxicology 2000; 21: 85-90.
  159. Furlong CE, Li WF, Shih DM, Lusis A, Richter RJ, Costa LG. Genetic factors in susceptibility:serum PON1 variation between individuals and species. Hum. Ecol. Risk Assessment 2002; 8: 31-44.
  160. Tiffany-Castiglioni E, Ehrich M, Dees L, Costa LG, Kodavanti PRS, Lasley SM, Oortgiesen M, Durham HD. Bridging the gap between in vitro and in vivo models. Toxicol. Sci. 1999; 51: 178-183.
  161. Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. Genetic and temporal determination of pesticide sensitivity: role of paraoxonase (PON1). NeuroToxicology 2000; 21: 91-100.
  162. Wei M, Guizzetti M, Yost M, Costa LG. Exposure to 60 Hz magnetic fields and proliferation of human astrocytoma cells in vitro. Toxicol. Appl. Pharmacol. 2000; 162: 166-176.
  163. Costa-Mallen P, Checkoway H, Fishel M, Cohen AW, Smith-Weller T, Franklin GM, Swanson PD, Costa LG. The EcoRV genetic polymorphism of monoamine oxidase type A is not associated with Parkinson’s disease and does not modify the effect of smoking on Parkinson’s disease. Neurosci. Lett. 2000; 278: 33-36.
  164. Catlin MC, Guizzetti M, Costa LG. Effect of ethanol on muscarinic receptor-induced calcium responses in astroglia. J. Neurosci. Res. 2000; 60: 345-355
  165. Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG. The PON1 gene and detoxication. NeuroToxicology 2000; 21: 581-588.
  166. Zurich MG, Honegger P, Schilter B, Costa LG, Monnet-Tschudi F. Use of aggregating brain cell cultures to study the developmental effects of organophosphosrus insecticides. NeuroToxicology 2000; 21: 599-605.
  167. Monnet-Tschudi F, Zurich MG, Schilter B, Costa LG, Honegger P. Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures. Toxicol. Appl. Pharmacol. 2000; 165: 175-183.
  168. Guizzetti M, Costa LG. Muscarinic receptors, protein kinase C isozymes and proliferation of astroglial cells: effects of ethanol. Neurotoxicology 2000; 21: 1117-1122.
  169. Guizzetti M, Costa LG. Possible role of protein kinase C z in muscarinic receptor-induced proliferation of astrocytoma cells. Biochem. Pharmacol. 2000; 60:1457-1466.
  170. Costa-Mallen P, Costa LG, Smith-Weller T, Franklin GM, Swanson PD, Checkoway H. Genetic polymorphism of dopamine D2 receptors in Parkinson’s disease and interactions with cigarette smoking and MAO-B intron 13 polymorphism.J. Neurol. Neurosurg. Psych. 2000; 69: 535-537.
  171. Catlin MC, Kavanagh TJ, Costa LG. Muscarinic receptor-induced calcium responses in astroglia. Cytometry 2000; 41: 123-132.
  172. Oberdoester J, Guizzetti M, Costa LG. The effect of phenylalanine and its metabolites on the proliferation and viability of neuronal and astroglial cells:possible relevance in maternal phenylketonuria. J. Pharmacol. Exp. Ther. 2000; 295: 295-301.
  173. Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. Catalytic efficiency determines the in vivo efficacy of PON1 for detoxifying organophosphates. Pharmacogenetics 2000; 10: 767-779.
  174. Costa LG, Guizzetti M, Oberdoester J, Yagle K, Costa-Mallen P, Tita B, Bordi F, Vitalone A, Palmery M, Valeri M. Modulation of DNA synthesis by muscarinic cholinergic receptors. Growth Factors 2001; 18: 227-236.
  175. Costa LG, Guizzetti M, Lu, H, Bordi F, Vitalone A, Tita B, Palmery M, Valeri P, Silvestrini B. Intracellular signal transduction pathways as targets for neurotoxicants. Toxicology 2001; 160:19-26.
  176. Guizzetti M, Costa LG. Activation of phosphatidylinositol 3-kinase by muscarinic receptors in astrocytoma cells. NeuroReport 2001; 12:1639-1642.
  177. Lu H, Guizzetti M, Costa LG. Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase C a. J. Neurochem. 2001; 78:590-599.
  178. Yagle K, Lu H, Guizzetti M, Moller T, Costa LG. Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: role in DNA synthesis and effect of ethanol. Glia 2001; 111-120.
  179. Lu H, Guizzetti M, Costa LG. Inorganic lead activates the MEK-MAPK-p90RSK pathway in human astrocytoma cells via a PKC-dependent mechanism. J. Pharmacol. Exp. Ther 2002; 300: 818-823.
  180. Costa LG, Guizzetti M, Burry M, Oberdoester J. Developmental neurotoxicity: do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria. Toxicol. Lett. 2002; 127: 197-205.
  181. Costa LG, Guizzetti M. Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the fetal alcohol syndrome. Neurotoxicology 2002; 23:685-691.
  182. Guizzetti M, Costa LG. Effect of ethanol on protein kinase C z and p70S6 kinase activation by carbachol: a possible mechanism for ethanol-induced inhibition of glial cell proliferation. J. Neurochem. 2002; 82: 38-46.
  183. Costa LG, Richter RJ, Li WF, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003; 8: 1-12.
  184. Furlong CE, Cole TB, Jarvik GP, Costa LG. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenomics 2002; 3: 341-348.
  185. Branchi I, Alleva E, Costa LG. Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioral development. Neurotoxicology 2002; 23: 375-384.
  186. Kelada SN, Costa-Mallen P, Costa LG, Smith-Weller T, Franklin GM, Swanson PD, Longstreth Jr WT, Checkoway H. Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease. Neurotoxicology 2002; 23: 515-519.
  187. Costa LG, Cole TB, Furlong CE. Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. J. Toxicol. Clin Toxicol. 2003; 41: 37-45.
  188. Costa LG, Cole TB, Jarvik GP, Furlong CE. Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annu. Rev. Med. 2003; 54: 371-392.
  189. Kelada SN, Costa-Mallen P, Checkoway H, Furlong CE, Jarvik GP, Viernes HA, Farin FM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Costa LG. Paraoxonase 1promoter and coding region polymorphisms in Parkinson’s disease. J. Neurol. Neurosurg. Psych. 2003; 74: 546-547.
  190. Burry M, Guizzetti M, Oberdoester J, Costa LG. Developmental neurotoxicity of toluene: in vivo and in vitro effects on astroglial cells. Dev. Neurosci. 2003; 25: 14-19.
  191. Vitalone A, Guizzetti M, Costa LG, Tita B. Extracts of various species of Epilobium inhibit proliferation of human prostate cells. J.Pharm. Pharmacol. 2003; 55: 683-690.
  192. Branchi I, Capone F, Alleva E, Costa LG. Polybrominated diphenyl ethers: neurobehavioral effects following developmental exposure. Neurotoxicology 2003; 24: 449-462.
  193. Tsuji R, Guizzetti M, Costa LG. In vivo ethanol decreases phosphorylated MAPK and p70S6 kinase in the developing rat brain. Neuroreport 2003; 14: 1395-1399.
  194. Guizzetti M, Moeller T, Costa LG. Ethanol inhibits muscarinic receptor-mediated DNA synthesis and signal transduction in human fetal astrocytes. Neurosci. Lett. 2003; 344: 68-70.
  195. Cole TB, Jampsa RL, Walter BJ, Arndt TL, Richter RJ, Shih DM, Tward A, Lusis AJ, Jack RM, Costa LG, Furlong CE. Expression of human paraoxonase (PON1) during development. Pharmacogenetics 2003; 13: 357-364.
  196. Guizzetti M, Bordi F, Dieguez-Acuna FJ, Vitalone A, Madia F, Woods JS, Costa LG. Nuclear factor kB activation by muscarinic receptors in astroglial cells: effect of ethanol. Neuroscience 2003; 120: 941-950.
  197. Vitalone A, McCall J, Thome D, Costa LG, Tita B. Characterization of the effects of Epilobium extracts on human cell proliferation. Pharmacology 2003; 69: 79-87.
  198. Evandri MG, Costa LG, Bolle P. Evaluation of brominated diphenyl ether-99 toxicity with Raphidocelis subcapitata and Daphnia magna. Environ. Toxicol. Chem. 2003; 22: 2167-2172.
  199. Evandri MG, Costa LG, Bolle P. In vitro assessment of mutagenicity and clastogenicity of BDE-99, a pentabrominated diphenyl ether flame retardant. Environ. Mol. Mutagen. 2003; 42: 85-90.
  200. Costa LG, Lovreglio P, Vitalone A, Soleo L. Role of genetic polymorphism in risk assessment. G. Ital. Med. Lav. Ergon. 2003; 25: 320-327.
  201. Costa-Mallen P, Afsharinejad Z, Kelada SN, Costa LG, Franklin GM, Swanson PD, Longstreth WT, Viernes HA, Farin FM, Smith-Weller T, Checkoway H. DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson’s disease cases and unrelated controls. Mov. Disord. 2004; 19:76-82.
  202. Costa LG, Steardo L, Cuomo V. Structural effects and neurofunctional sequelae of developmental exposure to psychotherapeutic drugs: experimental and clinical aspects. Pharmacol. Rev. 2004; 56: 103-147.
  203. Costa LG, Aschner M, Vitalone A, Syversen T, Porat-Soldin O. Developmental neuropathology of environmental agents. Annu. Rev. Pharmacol. Toxicol. 2004; 44: 87-110.
  204. Costa LG, Vitalone A, Guizzetti M. Signal transduction mechanisms involved in the antiproliferative effects of ethanol in glial cells. Toxicol. Lett. 2004; 149: 67-73.
  205. Costa LG, Kelada SN, Costa-Mallen P, Farin FM, Viernes HA, Smith Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H, Furlong CE. Paraoxonase 2 (PON2) polymorphisms and Parkinson's disease. Neurosci. Res. Comm. 2004; 34: 130-135.
  206. Guizzetti M, Thompson BD, Kim Y, VanDeMark K, Costa LG. Role of phospholipase D signaling in ethanol induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. J. Neurochem. 2004; 90:646-653.
  207. Zurich MG, Honegger P, Schilter B, Costa LG, Monnet-Tschudi F. Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos. Toxicol. Sci. 2004; 201: 97-104.
  208. Costa LG, Guizzetti M, Vitalone A. Diet-brain connections: role of neurotoxicants. Env. Toxicol. Pharmacol. 2005; 19: 395-400.
  209. Madia F, Giordano G, Fattori V, Vitalone A, Branchi I, Capone F, Costa LG. Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in astrocytoma cells. Toxicol. Lett. 2004; 154: 11-21.
  210. Guizzetti M, Costa LG. Disruption of cholesterol homeostasis in the developing brain as a potential mechanism contributing to the developmental neurotoxicty of ethanol: an hypothesis. Med. Hypotheses 2005; 64: 563-567.
  211. Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AJ, Lusis AJ, Costa LG. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology 2005; 26: 651-659.
  212. Costa LG, Vitalone A, Cole TB, Furlong CE. Modulation of paraoxonase (PON1) activity. Biochem. Pharmacol. 2005; 69: 541-550.
  213. Costa LG, Cole TB, Vitalone A, Furlong CE. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clin. Chim. Acta 2005; 352: 37-47.
  214. Giordano G, Sanchez-Perez AM, Burgal M, Montoliu C, Costa LG, Felipo V. Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture. J. Neurochem 2005; 92: 143-157.
  215. Branchi I, Capone F, Vitalone A, Madia F, Santucci D, Alleva E, Costa LG. Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioral profile: interference from the administration route. Neurotoxicology 2005; 26: 183-192.
  216. Giordano G, Sanchez-Perez M, Montoliu C, Berezney R, Malyavantham K, Costa LG, Calvete JJ, Felipo V. Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death. J. Neurochem. 2005; 94: 808-818.
  217. Costa-Mallen P, Kelada SN, Costa LG, Checkoway H. Characterization of the in vitro transcriptional activity of polymorphic alleles of the human monoamine oxidase-B gene. Neurosci. Lett. 2005; 383: 171-175.
  218. Costa-Mallen P, Costa LG, Checkoway LG. Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men. Neuroscience Lett. 2005; 385:158-162.
  219. Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenetics Genom. 2005; 15: 589-598.
  220. Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG. Paraoxonase (PON1) status and risk of insecticide exposure. J. Biochem. Mol. Toxicol. 2005; 19: 182-183.
  221. Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 2005; 215: 182-190.
  222. Kelada SN, Costa-Mallen P, Checkoway H, Carlson CS, Smith-Weller T, Swanson PD, Franklin GM, Longsterth WT, Afsharinejad Z, Costa LG. Dopamine transporter (SCL6A3) 5’ region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson’s disease. Pharmacogenet. Genomics 2005; 15: 659-668.
  223. Golub M, Costa LG, Crofton K, Frank D, Fried P, Gladen B, Henderson R, Liebelt E, Lusskin S, Marty S, Rowland A, Scialli J, Vore M. NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of methylphenidate. Birth Defects Res. B Dev. Reprod. Toxicol. 2005; 74: 300-381.
  224. Golub M, Costa LG, Crofton K, Frank D, Fried P, Gladen B, Henderson R, Liebelt E, Lusskin S, Marty S, Rowland A, Scialli J, Vore M. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine. Birth Defects Res. B Dev. Reprod. Toxicol 2005; 74:471-584.
  225. Costa LG, Cole TB, Furlong CE. Paraoxonase (PON1): from toxicology to cardiovascular medicine. Acta Biomedica 2005; Suppl.2: 50-57.
  226. Costa LG, Cole TB, Furlong CE. Gene-environment interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity. Lab. Med.2006; 37: 1-5.
  227. Costa LG. Current issues in organophosphate toxicology. Clin. Chim. Acta 2006; 366:1-13.
  228. Guizzetti M, Costa LG. Cholesterol homeostasis in the developing brain: a possible new target for ethanol. Hum. Exp. Toxicol. 2007; 60: 355-360.
  229. Kelada S, Checkoway H, Kardia SLR, Carlson CS, Costa-Mallen P, Eaton DL, Firestone J, Powers KM, Swanson PD, Franklin GM, Longstreth WT, Smith-Weller T, Afsharinejad Z, Costa LG. 5’ and 3’ region variability in the dopamine transporter gene (slc6a3), pesticide exposure and Parkinson’s disease risk: a hypothesis-generating study. Human Mol. Genet. 2006; 15: 3055-3062.
  230. Giordano G, White CC, McConnachie LA, Fernandez C, Kavanagh TJ, Costa LG. Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Mol. Pharmacol. 2006; 70: 2116-2126.
  231. Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol. Appl. Pharmacol. 2007; 219: 181-189.
  232. Costa LG. Contaminants in fish: risk-benefit considerations. Arch. Ind. Hyg. Toxicol. 2007; 58: 367-374.
  233. Costa LG, Fattori V, Giordano G, Vitalone A. An in vitro approach to assess the toxicity of certain food contaminants: methylmercury and polychlorinated biphenyls. Toxicology 2007; 237: 65-76.
  234. Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Front. Biosci. 2008; 13: 1240-1249.
  235. Guizzetti M, Chen J, Oram JF, Tsuji R, Dao K, Moeller T, Costa LG. Ethanol induces cholesterol efflux and upregulation of ATP-binding casssette cholesterol transporters in fetal astrocytes. J. Biol. Chem. 2007; 282: 18740-18749.
  236. Corsi P, D’Aprile A, Nico B, Costa LG, Assennato G. Synaptic contacts impaired by styrene-7,8-oxide toxicity. Toxicol. Appl. Pharmacol. 2007; 22: 49-59.
  237. Fattori V, Abe SI, Kobayashi K, Costa LG, Tsuji R. Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain. J. Appl. Toxicol. 2008; 28: 370-376.
  238. Giordano G, White CC, Mohar I, Kavanagh TJ, Costa LG. Glutathione levels modulate domoic acid-induced apoptosis in mouse cerebellar granule cells. Toxicol. Sci. 2007; 100: 433-444.
  239. Costa LG, Kavanagh TJ, Giordano G. Glutathione levels modulate the neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants in mouse neurons and astrocytes. Organohal. Comp. 2007; 69: 421-423.
  240. Costa LG, Giordano G. Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants. Neurotoxicology 2007; 28: 1047-1067.
  241. Vitalone A, Catalani A, Chiodi V, Cinque C, Fattori V, Goldoni M, Matteucci P, Poli D, Zuena AR, Costa LG. Neurobehavioral assessment of rats exposed to low doses of PCB 126 and methyl mercury during development. Env. Toxicol. Pharmacol. 2008; 25: 103-113.
  242. Giordano G, Klintworth HM, Kavanagh TJ, Costa LG. Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases. Neurochem. Int. 2008; 52: 1100-1105.
  243. Tsuji R, Fattori V, Abe S, Costa LG, Kobayashi K. Effects of postnatal ethanol exposure at different developmental phases on neurotrophic factors and phosphorylated proteins on signal transductions in rat brain. Neurotoxicol. Teratol. 2008; 30: 228-236.
  244. Bal-Price AK, Sunol C, Weiss DG, van Vliet E, Westerink RH, Costa LG. Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs. Neurotoxicology 2008; 29: 519-530.
  245. Caglieri A, Goldoni M, De Palma G, Mozzoni P, Gemma S, Vichi S, Testai E, Panico F, Corradi M, Tagliaferri S, Costa LG. Exposure to low levels of hexavalent chromium: target doses and comparative effects on two human pulmonary cell lines. Acta Biomedica 2008; 79 (Suppl. 1): 104-115.
  246. Giordano G, Kavanagh TJ, Costa LG. Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicol. Appl. Pharmacol. 2008; 232: 161-168.
  247. Guizzetti M, Moore NH, Giordano G, Costa LG. Modulation of neuritogenesis by astrocyte muscarinic receptors. J. Biol. Chem. 2008; 283: 31884-31897.
  248. Eaton DL, Daroff, RB, Autrup H, Bridges, J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit. Rev. Toxicol. 2008; 38 (Suppl. 2): 1-125.
  249. Guizzetti M, Costa LG. Sonic hedgehog in Smith-Lemli-Opitz syndrome and tumor development. J. Pediatr. Hematol. Oncol. 2008; 30: 641-642.
  250. Costa LG, Giordano G, Tagliaferri S, Caglieri A, Mutti A. Polybrominated diphenyl ether (PBDE) flame retardants: environmental contamination, human body burden and potential adverse effects. Acta Biomedica 2008; 79: 172-183.
  251. Moore NH, Costa LG, Shaffer SA, Goodlett D R, Guizzetti M. Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation. J. Neurochem. 2009; 108: 891-908.
  252. Giordano G. Kavanagh TJ, Costa LG. Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71. Neurotoxicology 2009; 30: 326-329.
  253. Giordano G, Li L, White CC, Farin FM, Wilkerson HW, Kavanagh TJ, Costa LG. Muscarinic receptors prevent oxidative stress-mediated apoptosis induced by domoic acid in mouse cerebellar granule cells. J. Neurochem. 2009; 109: 525-538.
  254. Jansen KL, Cole TB, Park SS, Furlong CE, Costa LG. Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds. Toxicol. Appl. Pharmacol 2009; 236: 142-153.
  255. VanDeMark KL, Guizzetti M, Giordano G, Costa LG. The activation of M muscarinic receptor signaling induces neuronal differentiation in pyramidal hippocampal neurons. J. Pharmacol. Exp. Ther. 2009; 329: 532-542.
  256. Giordano G. Pizzurro D, VanDeMark KL, Guizzetti M, Costa LG. Manganese inhibits the ability of astrocytes to promote neuronal differentiation. Toxicol. Appl. Pharmacol. 2009; 240: 226-235.
  257. VanDeMark KL, Guizzetti M, Giordano G, Costa LG. Ethanol inhibits muscarinic receptor-induced axonal growth in rat hippocampal neurons. Alcohol Exp. Clin. Res. 2009; 33:1945-1955.
  258. Del Rio D, Costa LG, Lean MEJ, Crozier A. Polyphenols and health: what compounds are involved? Nutr. Metab. Cardiovasc. Dis. 2010; 20: 1-6.
  259. Tagliaferri S, Caglieri A, Goldoni M, Pinelli S, Alinovi R, Poli D, Pellacani C, Giordano G, Mutti A, Costa LG. Low concentrations of the brominated flame retardants BDE-47 and BDE-99 induce synergistic oxidative stress-mediated neurotoxicity in human neuroblastoma cells. Toxicol. In Vitro 2010; 24: 116-122.
  260. Huang S, Giordano G, Costa LG. Comparative cytotoxicity and intra-cellular accumulation of five polybrominated diphenyl ether (PBDE) congeners in mouse cerebellar granule neurons. Toxicol. Sci. 2010; 114: 124-132.
  261. Cole TB, Jansen K, Park S, Li WF, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphorus compounds is modulated by paraoxonase 1 status. Adv. Exp. Med. Biol. 2010; 660: 47-60.
  262. Furlong CE, Suzuki SM, Stevens RC, Marsillach J, Richter RJ, Jarvik GP, Checkoway H, Samil A, Costa LG, Griffith A, Roberts JW, Yearout D, Zabetian CP. Human PON1, a biomarker of risk of disease and exposure. Chem. Biol. Interact. 2010; 187: 355-361.
  263. Guizzetti M, Moore NH, Giordano G, VanDeMark KL, Costa LG. Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia 2010; 58: 1395-1406.
  264. Vitalone A, Catalani A, Cinque C, Fattori V, Matteucci P, Zuena AR, Costa LG. Long-term effects of developmental exposure to low doses of PCB 126 and methylmercury during development. Toxicol. Lett. 2010; 197: 38-45.
  265. Costa LG, Giordano G, Faustman EM. Domoic acid as a developmental neurotoxin. Neurotoxicology 2010; 31: 409-423.
  266. Costa LG, Giordano G, Guizzetti M. In vitro models to study cell-cell interactions that influence developmental neurotoxicity. ALTEX 2010; 27 (Suppl. 1): 303-308.
  267. Costa LG, Giordano G, Furlong CE. Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: The hunt goes on. Biochem. Pharmacol. 2011; 81: 337-344.
  268. Costa LG, Giordano G. Is decabromodiphenyl ether (BDE 209) a developmental neurotoxicant? Neurotoxicology 2011; 32: 9-24.
  269. Verzelloni E, Pellacani C, Tagliazucchi D, Tagliaferri S, Calani L, Costa LG, Brighenti F, Crozier A, Conte A, Del Rio D. Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites, Mol. Nutr. Food Res. 2011; 55 (Suppl. 1): S35-S43.
  270. Giordano G, Cole TB, Furlong CE, Costa LG. Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role? Toxicol. Appl. Pharmacol. 2011; 256: 369-378.
  271. Guizzetti M, Moore NH, VanDeMark KL, Giordano G, Costa LG. Muscarinic receptor-activated signal transduction pathways involved in the neuritogenic effect of astrocytes in hippocampal neurons. Eur. J. Pharmacol. 2011; 659: 102-107.
  272. Cole TB, Giordano G, Co AL, Mohar I, Kavanagh TJ, Costa LG. Behavioral characterization of the Gclm knockout mouse, a model for enhanced susceptibility to oxidative stress. J. Toxicol. 2011; 2011:157687.
  273. Chen J, Costa LG, Guizzetti M. Retinoic acid isomers up-regulate ATP binding cassette a1 and g1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects. J. Pharmacol. Exp. Ther. 2011; 338: 870-878.
  274. Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE. PON1 status modulates cerebellar gene expression changes associated with repeated developmental exposure of mice to chlopyrifos oxon. Toxicol. Sci. 2011; 123: 155-169.
  275. Battilani P, Gualla A, Dall’Asta C, Pellacani C, Galaverna G, Giorni P, Caglieri A, Tagliaferri S, Spadaro D, Pietri A, Dossena A, Marchelli R, Gullino ML, Costa LG. Phomopsin: an overview of phytopathological and chemical aspects, toxicity, analysis and occurrence. World Mycotoxin J. 2011; 4: 345-359.
  276. Giordano G, Guizzetti M, Dao K, Mattison HA, Costa LG. Ethanol impairs muscarinic receptor-induced neuritogenesis in rat hippocampal slices: role of astrocytes and extracellular matrix proteins. Biochem. Pharmacol. 2011; 82: 1792-1799.
  277. Pellacani C, Tagliaferri S, Caglieri A, Goldoni M, Giordano G, Mutti A, Costa LG. Synergistic interactions between PBDEs and PCBs in human neuroblastoma cells. Environ. Toxicol. 2012 (in press).
  278. Cole TB, Fisher JC, Burbacher TM, Costa LG, Furlong CE. Neurobehavioral assessment of mice following repeated postnatal exposures to chlorpyrifos oxon. Neurotoxicol. Teratol. 2012 (in press).
Review date: 
3/24/2016