Lucio G. Costa, PharmD

Professor, Env. and Occ. Health Sciences (Primary department)
The general area of research in Dr. Costa's laboratory is neurotoxicology. Neurotoxic substances may play a role in neurodevelopmental disorders, and in neurological, neuropsychiatric and neurodegenerative diseases. Dr. Costa's laboratory is interested in the study of the cellular, biochemical and molecular mechanisms involved in neurotoxicity, as well as behavioral testing, imaging techniques and transgenic animal models.

Contact Information

Box: 354695
4225 Roosevelt Suite 100
Seattle, WA 98195-
Tel: 206-543-2831

Research Interests

  • Neurotoxicology. Molecular mechanisms of neurotoxicity. Biochemical markers of neurotoxicity. Children's health. Food additives and contaminants. Genetic susceptibility. In vitro toxicology. Pesticides and children. Neurotoxicity of diesel exhaust. Paraoxonase 1 and paraoxonase 2. Metals and oxidative stress. Gender-differences in oxidative stress and neurotoxicity. Air pollution and autism related disorders. Neurotoxicity of air pollution. Air pollution and neurodegenerative diseases.

Teaching interests

ENVH 531 Neurotoxicology (3 credits, Winter Quarter, Even years)
ENVH 516 Toxic Agents: Effects and Mechanisms (3 credits, Spring Quarter)

Education

PharmD, Pharmacology, University of Milan (Italy), 1977

Projects

Studies on the neurotoxicity and developmental neurotoxicity of environmental exposure to traffic-related air pollution (e.g. diesel exhaust) with focus on oxidative stress, neuroinflammation and markers of neurodegenerative diseases. Studies include in vivo exposures in mice, and biochemical, behavioral and immunohistochemical measurements.

Studies on the role of paraoxonase 2 as a determinant of sex-linked differences in susceptibility to neurotoxicity using transgenic mice and in vitro and in vivo approaches.

Studies on the role of paraoxonase 1 in modulating susceptibility to organophosphate toxicity.

Studies on the role of paraoxonase 2 as a determinant of sex-linked differences in susceptibility to neurotoxicity using transgenic mice and in vitro and in vivo approaches.

Studies on the role of paraoxonase 1 in modulating susceptibility to organophosphate toxicity.

Study of the expression and neuroprotective functions of paraoxonase 2 (PON2) in the central nervous system.

Study of the neurotoxic effects of exposure to diesel exhaust
Selected Publications
Coburn JL, Cole TB, Khoi D, Costa LG. Acute exposure to diesel exhaust impairs adult neurogenesis in mice: prominence in males and protective effect of pioglitazone. Arch. Toxicol. 2018; 92: 1815-1829.
 
Chang YC, Cole TB, Costa LG. Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice. Part. Fibre Toxicol. 2018; 15 (1): 18.
 
Costa LG. Traffic-related air pollution and neurodegenerative diseases: epidemiological and experimental evidence. IN: Advances in Neurotoxicology, Vol. 1, Aschner M, Costa LG, eds., Elsevier, New York, 2017; pp. 1-47.
 
Costa LG, Cole TB, Garrick JM, Marsillach J, Furlong CE. Metals and paraoxonases. IN Neurotoxicity of Metals. Aschner M, Costa LG, eds. Advances in Neurobiology Series, Springer, New York, 2017; 18: 85-111.
 
Costa LG, Chang YC, Cole TB. Developmental neurotoxicity of traffic-related air pollution: focus on autism. Curr. Environ. Health Rep. 2017; 4: 156-165.
 
Chang YC, Cole TB, Costa LG. Behavioral phenotyping for autism spectrum disorders in mice. IN: Current Protocols in Toxicology, LG Costa, D Lawrence, Y Will, JC Davila, eds., John Wiley & Sons, New York, NY 2017; 11.22.1-11.22.21.
 
Costa LG, Cole TB, Coburn J, Chang YC, Dao K, Roque P. Neurotoxicity of traffic-related air pollution. Neurotoxicology 2017; 59: 133-139.
 
Roqué PJ, Dao K, Costa LG. Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms. Neurotoxicology 2016; 56: 204-214.
 
Cole TB, Coburn J, Dao K, Roque P, Kalia V, Guilarte TR, Dziedzic J, Costa LG. Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology 2016; 374: 1-9.
 
Costa LG, de Laat R, Dao K, Pellacani C, Cole TB, Furlong CE. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology 2014; 43: 3-9.
 
Review date: 
3/24/2016