Evan Gallagher, PhD, MEM

Professor, Env. and Occ. Health Sciences (Primary department)
Dr. Gallagher joined the faculty of the University of Washington in 2004 as Sheldon D. Murphy Associate Professor of Toxicology. Dr. Gallagher was formerly an Associate Professor at the University of Florida were he also served as Director of the Aquatic Toxicology Laboratory in the College of Veterinary Medicine. Dr. Gallagher serves as the Director of the UW Superfund Research Program, a multi-investigator and multi-institutional center funded by NIEHS that addresses the effects of neurotoxic chemicals on ecological and human health. In addition to his Superfund activities, he is also an active member of the UW Center for Ecogenetics and Environmental Heath (CEEH) and the UW training grant in Environmental Pathology and Toxicology. Dr. Gallagher is a member of the Society of Toxicology as well as the Society of Environmental Toxicology and Chemistry. Dr. Gallagher maintains an active research and teaching program focused on chemical injury in aquatic organisms, and using approaches that integrates molecular, biochemical physiological and behavioral endpoints., Accordingly, students and post-docs in Dr. Gallagher's laboratory potentially have the opportunity to work in the areas of comparative toxicology of aquatic organisms, and also using fish models to address the environmental impacts of chemical exposures on human health.

Contact Information

Box: 357234
Seattle, WA 98105-6099
Tel: 206-616-4739
Tel: 206-543-1005
Fax: 206-685-4696

Research Interests

  • Aquatic Toxicology, Drug Metabolism, Pesticides, Emerging Contaminants, Metals, olfactory injury, Superfund Sites, Toxicogenomics, zebrafish, transgenics, oxidative stress, mitochondrial injury, PBDEs
  • KEYWORDS: Aquatic toxicology, Drug metabolism, species differences in susceptibility to toxicants, Pesticides, Superfund sites, Toxicogenomics, Toxicology, Genetic susceptibility to toxicants, Superfund sites

Teaching interests

ENV H 533 Molecular toxicologyENV H 534 Biochemical toxicology of the Puget SoundENV H 405 Toxic chemicals and human health

Education

PhD, Biochemical Toxicology, Duke University, 1991
MEM, Ecotoxicology and Environmental Chemistry, Duke University, 1986

Projects

Funding from the NIEHS Superfund Research program has provided support to address the mechanisms of how environmental chemicals block olfactory function in salmon. Zebrafish are also used to address the role of microRNAs in the disruption of olfactory gene expression during chemical exposures. Transgenic zebrafish strains are enabling confocal fluorescence visualization of olfactory receptor neurons that are sensitive to metals and pesticides, and including Nrf2 transgenics to understand antioxidant responses to cell injury. Zebrafish transgenics are also being generated for NSF-funded studies to evaluate the role of oxidative stress and olfactory injury of understudied environmental industrial chemicals. Dr. Gallagher has been funded by Washington Department of Ecology to develop new biomarkers of exposure and effects to emerging contaminants in Puget Sound fish, with a focus on using Chinook salmon and staghorn sculpin. Funding from Washington Sea Grant is supporting studies that address the effects of ocean acidification on salmon neurobehavioral function. He has continued his long-term studies on the comparative biochemistry of glutathione S-transferases. Practical applications of our aquatic toxicology work involve the development and field application of biochemical and molecular biomarkers of pollutant exposure and effects in salmonids, as well in providing better identification of fish populations at particular risk to environmental chemical injury. Collectively, his work involves environmental toxicological issues that cross ecosystem and human health boundaries in the context of environmental health.
Selected Publications

1. Yeh, A., Meador, J., Marcinek, D., and E. GALLAGHER. 2017. Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon. Aquatic Toxicology. Epub 2017 Jun 16.

2. Meador, J., Yeh, A., Young, G., and E. GALLAGHER. 2017. Determining potential adverse effects in marine fish exposed to pharmaceuticals and personal care products with the fish plasma model and whole-body tissue concentrations. Environ. Pollution. In press.

3. Mills, M. G. and E. Gallagher. 2017. A targeted gene expression platform allows for rapid analysis oxidant-induced antioxidant mRNA expression in zebrafish larvae. PLoS One. Feb 17;12(2)

4. Corrales, J., Kristofco L. A., Steele, W. B., Saari, G. N., Kostal, J., Williams, E. S., Mills, M., GALLAGHER, E., Kavanagh, T. J., Simcox, N., Shen, L. Q., Melnikov, F., Zimmerman, J. B., Voutchkova-Kostal, A., Anastas P, Brooks BW. 2017.Towards the design of less hazardous chemicals: Exploring comparative oxidative stress in two common animal models. Environmental Science and Technology. Apr 17;30(4):893-904.

5. Coish, P., Brooks, B., GALLAGHER, E., Kavanagh,T., Voutchkova-Kostal, A., Zimmerman, J., and P. Anastas. 2016. Current Status and Future Challenges in the Molecular Design for Reduced Hazard. Sustainable Chem. and Engineering. 4:5900-5906.

6. Williams, C., Mcdonald, J., Bammler, T., Simpson, C., Paulsen, M., and E. GALLAGHER. 2016. Cadmium exposure differentially alters odorant-driven behaviors and expression of olfactory receptors in juvenile coho salmon (Oncorhynchus kisutch). Toxicol. Sciences. Dec;154(2):267-277

7. Ramsden, R. and E. GALLAGHER. 2016. E. GALLAGHER. Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets. Redox Biology. Jul 6;9:114-123.

8. Meador, J., Yeh, A., Young, G., and E. GALLAGHER. 2016. Contaminants of emerging concern detected in effluent, estuarine water, and fish in Puget Sound, Washington, USA. Environmental Pollution. Jun;213:254-67.

9. Wang, L., Bammler, T., Beyer, R., McDonald, J., Yeh, A., Williams, C., and E. GALLAGHER. 2016. Transcriptional and biochemical effects of binary organophosphate mixtures on the Coho salmon olfactory system. Toxicol. Sciences. Jan;149(1):145-57.

Review date: 
6/11/2015