Consumer product safety
Health effects of mercury and other metals
Injury Epidemiology-- particularly focusing on work-place issues
Current areas of interest include community-based participatory research, policy intervention research and translation of research results to effect change in occupational or environmental health policy and decision making, as well as public health.
Pesticides and health. Developing biomarkers to assess human exposure to pesticides. The effects of pesticides in honeybees, mammals and humans.
Adverse health effects of ambient air pollution on susceptible populations including children, the elderly and those with preexisting health conditions
His research and professional interests are in the detection and prevention of foodborne illnesses, detection and monitoring of pathogens in the environment, laboratory method development and Food/Water provision and safety in the developing countries (i.e., food, water, air, garbage, water and wastewater issues).
Aquatic toxicology, exposure assessment, metabolic disruptors, tissue-residue toxicity, contaminants of emerging concern, PAHs, metals, organotins, PCBs.
Clinical and Biomedical Informatics
Databases and Computing
Medical and Translational Research
Proteomics and Metabolomics
Systemic Modeling and Systems Biology
Dr. Omiecinski's research centers on the molecular genetics and regulation of human xenobiotic detoxication. The laboratory's toxicogenomic investigations seek to characterize critical determinants that specify the underlying mechanisms dictating the variable nature of interindividual responsiveness to drug and chemical exposure. One specific focus of the laboratory is the study of human microsomal epoxide hydrolase. The laboratory has characterized structural polymorphisms as well as the use of alternative gene promoter mechanisms that contribute as potential risk modifiers for chemical toxicity mediated by epoxide intermediates. Another area of focus is the biological regulation conferred by nuclear receptors, in particular the constitutive androstane receptor. Xenobiotic receptors, such as CAR and PXR, sense the cellular chemical environment and function in key regulatory circuitry that tunes the cell's genomic expression program to accommodate the specific chemical milieu. These receptor control circuits exhibit diversity within cells, tissues and among individuals, in part due to the generation of structurally distinct sets of receptors generated by alternative RNA splicing - an area of particular research focus for the laboratory.
Drinking water quality and treatment, analytical method development, oxidation kinetics, disinfection byproducts, harmful algal blooms, source apportionment of chemical contaminants (nitrates, fracking fluid) in household wells and removal by point-of-use water treatment.
One Health/Global Health/Planetary Health: Studying relationships between and identifying multidisciplinary approaches to improve human, animal, and ecosystem sustainability and health.
Emerging Zoonotic Infectious Diseases: Improving disease surveillance; prevention, response and control of these diseases in human and animal populations.
Global Health and Security: Addressing zoonotic and other infectious infectious disease threats, food safety, malaria prevention and control